Results 51 to 60 of about 10,821 (218)

Syndecan-4 Promotes Epithelial Tumor Cells Spreading and Regulates the Turnover of PKCα Activity under Mechanical Stimulation on the Elastomeric Substrates

Cellular Physiology and Biochemistry, 2015
Background: Heparan sulfate proteoglycans (HSPGs) at the cell surface play an important role in cell adhesion, spreading, formation of focal adhesion complexes (FACs), and sensing mechanical stress.
Chun-Ping Huang, Chao-Min Cheng, Hong-Lin Su, Yi-Wen Lin   +3 more
doaj   +1 more source

Syndecan-3 in Inflammation and Angiogenesis

Frontiers in Immunology, 2020
Syndecans are a four member multifunctional family of cell surface molecules with diverse biological roles. Syndecan-3 (SDC3) is the largest of these, but in comparison to the other family members relatively little is known about this molecule. SDC3 null
Samantha Arokiasamy, Michaela J. M. Balderstone, Giulia De Rossi, James R. Whiteford   +3 more
doaj   +1 more source

Variations in the Peritrophic Matrix Composition of Heparan Sulphate from the Tsetse Fly, Glossina morsitans morsitans [PDF]

, 2018
Tsetse flies are the principal insect vectors of African trypanosomes—sleeping sickness in humans and Nagana in cattle. One of the tsetse fly species, Glossina morsitans morsitans, is host to the parasite, Trypanosoma brucei, a major cause of African ...
Acosta-Serrano, A, Guimond, S, Lima, M, Pelletier, J, Rogerson, E, Rose, C, Skidmore, MA, Taylor, S, Yates, E   +8 more
core   +5 more sources

Mechanical Cues Regulate Cargo Sorting and Export at the Golgi

Advanced Science, EarlyView.
A pathway is identified linking extracellular matrix stiffness to secretion via Src–FAK–AMPK–GBF1 signaling. Golgi‐localized GBF1 acts as a mechanotransducer whose phosphorylation controls post‐Golgi cargo sorting toward secretion or lysosomal degradation.
Greta Serafino, Stefania Forciniti, Edoardo Scarpa, Antonio Ranieri, Lucia Santorelli, Gabriella De Blasi, Sara Costantini, Eunjoo Jun Lee, Antonio Galeone, Alessia Calcagnì, Marinella Pirozzi, Loretta L. del Mercato, Rossella Venditti, Giovanni D'Angelo, Seetharaman Parashuraman, Tiziano Verri, Giuseppe Gigli, Elizabeth S. Sztul, Paolo Grumati, Loris Rizzello, Domenico Russo, Riccardo Rizzo   +21 more
wiley   +1 more source

Glycosaminoglycans and Proteoglycans

Pharmaceuticals, 2018
In this editorial to MDPI Pharmaceuticals special issue “Glycosaminoglycans and Proteoglycans” we describe in outline the common structural features of glycosaminoglycans and the characteristics of proteoglycans, including the intracellular proteoglycan,
Vitor H. Pomin, Barbara Mulloy
doaj   +1 more source

Succinic Acid‐Induced Macrophage Endocytosis Promotes Extracellular Vesicle‐Based Integrin Beta1 Transfer Accelerating Fibroblast Activation and Sepsis‐Associated Pulmonary Fibrosis

Advanced Science, EarlyView.
Lipopolysaccharide (LPS) stimulates the production of succinic acid in lung tissue, which promotes macrophages endocytosis and the formation of multivesicular bodies (MVBs). These MVBs release profibrotic extracellular vesicles (EVs), facilitating the transfer of integrin beta1 (ITGβ1) transfer and subsequently activating fibroblasts, thereby ...
Wenyu Yang, Ri Tang, Yang Zhou, Jinquan Zhang, Shuya Mei, Yawen Peng, Xi Huang, Shunpeng Xing, Yuan Gao, Qiaoyi Xu, Zhengyu He   +10 more
wiley   +1 more source

Is Endothelial Nitric Oxide Synthase a Moonlighting Protein Whose Day Job is Cholesterol Sulfate Synthesis? Implications for Cholesterol Transport, Diabetes and Cardiovascular Disease [PDF]

, 2012
Theoretical inferences, based on biophysical, biochemical, and biosemiotic considerations, are related here to the pathogenesis of cardiovascular disease, diabetes, and other degenerative conditions.
Ali, Ann Lauritzen, Billecke, Brune, Cignarelli, Cordelier, Deniziak, Dimmeler, Drayer, Gajkowska, Girard, Gross, Hao, Hart, Ho, Hopwood, Hopwood, Ignarro, Jagger, Jakubowski, Joensuu, Laurie Lentz-Marino, McCully, Nakae, Pfennig, Pollack, Randriamboavonjy, Rearick, Robert Davidson, Seidel, Stephanie Seneff, Suzuki, Tedder, Teske, Tsai, Voeikov   +35 more
core   +4 more sources

Multiscale Cell–Cell Interactive Spatial Transcriptomics Analysis

Advanced Science, EarlyView.
In this study, we present the MultiScale Cell‐Cell Interactive Spatial Transcriptomics Analysis method, which unites the strengths of spatially resolved deep learning techniques with a topological representation of multi‐scale cell‐cell similarity relations.
Sean Cottrell, Guo‐Wei Wei
wiley   +1 more source

Transmembrane Domain–Dependent Functional Oligomerization of Syndecans

The Scientific World Journal, 2006
Cell surface adhesion receptors of the syndecan family initiate intracellular events through clustering of receptors. This crucial clustering occurs through receptor dimerization or oligomerization, which is mediated by receptor transmembrane domains ...
Jae Youn Yi, Innoc Han, Eok-Soo Oh
doaj   +1 more source

Syndecans reside in sphingomyelin-enriched low-density fractions of the plasma membrane isolated from a parathyroid cell line. [PDF]

PLoS ONE, 2012
BACKGROUND: Heparan sulfate proteoglycans (HSPGs) are one of the basic constituents of plasma membranes. Specific molecular interactions between HSPGs and a number of extracellular ligands have been reported.
Katarzyna A Podyma-Inoue, Miki Hara-Yokoyama, Tamayuki Shinomura, Tomoko Kimura, Masaki Yanagishita   +4 more
doaj   +1 more source