Results 51 to 60 of about 11,102 (261)

Studying the Endothelial Glycocalyx in vitro: What Is Missing?

Frontiers in Cardiovascular Medicine, 2021
All human cells are coated by a surface layer of proteoglycans, glycosaminoglycans (GAGs) and plasma proteins, called the glycocalyx. The glycocalyx transmits shear stress to the cytoskeleton of endothelial cells, maintains a selective permeability ...
Andrew B. Haymet, Andrew B. Haymet, Nicole Bartnikowski, Nicole Bartnikowski, Emily S. Wood, Emily S. Wood, Michael P. Vallely, Angela McBride, Angela McBride, Sophie Yacoub, Sophie Yacoub, Scott B. Biering, Eva Harris, Jacky Y. Suen, Jacky Y. Suen, John F. Fraser, John F. Fraser   +16 more
doaj   +1 more source

Towards definition of an ECM parts list: An advance on GO categories [PDF]

, 2012
Those of us interested in the extracellular matrix (ECM) are faced with significant challenges of definition. ECM proteins are large, complex and assembled into crosslinked insoluble matrices.
Hoersch, Sebastian, Hynes, Richard O., Hynes, Richard O., Naba, Alexandra   +3 more
core   +1 more source

Isolation Defines Identity: Functional Consequences of Extracellular Vesicle Purification Strategies

Advanced Healthcare Materials, EarlyView.
Four extracellular vesicle purification strategies are compared using ovarian‐cancer ascites and ES‐2 cell supernatants. A novel workflow links purification to function by combining particle‐normalized proteomics with matched cell‐free and cell‐based assays.
Christian Preußer, Dolores J. Salander, Witold Szymanski, Johannes Graumann, Yukai Wang, Kai Zhao, Jörg W. Bartsch, María Gómez‐Serrano, Daniel Bachurski, Silke Reinartz, Elke von Pogge von Strandmann   +10 more
wiley   +1 more source

Syndecan-4 negatively regulates antiviral signalling by mediating RIG-I deubiquitination via CYLD

Nature Communications, 2016
Syndecans are transmembrane proteoglycans implicated in diverse cellular activities. Here the authors show that Syndecan-4 via its cytosolic domain negatively regulates antiviral immunity by enhancing RIG-I interaction with a deubiquitinating enzyme CYLD,
Wei Lin, Jing Zhang, Haiyan Lin, Zexing Li, Xiaofeng Sun, Di Xin, Meng Yang, Liwei Sun, Lin Li, Hongmei Wang, Dahua Chen, Qinmiao Sun   +11 more
doaj   +1 more source

Syndecan-4 Promotes Epithelial Tumor Cells Spreading and Regulates the Turnover of PKCα Activity under Mechanical Stimulation on the Elastomeric Substrates

Cellular Physiology and Biochemistry, 2015
Background: Heparan sulfate proteoglycans (HSPGs) at the cell surface play an important role in cell adhesion, spreading, formation of focal adhesion complexes (FACs), and sensing mechanical stress.
Chun-Ping Huang, Chao-Min Cheng, Hong-Lin Su, Yi-Wen Lin   +3 more
doaj   +1 more source

CD168 Identifies Proliferating Pancreatic Islet Cells in Murine and Human

Advanced Science, EarlyView.
This study identifies CD168 as a conserved surface marker for proliferating β‐cells in mouse, human islets, and pancreatic islet tumors. CD168⁺ cells show high proliferation and low insulin expression. CD168+ cells form mostly uni‐β lineage clones, and some of the clones are multi‐lineage.
Shubo Yuan, Jiafu Li, Min Shao, Haili Bao, Ajun Geng, Jialin Yang, Yu Tao, Xinyi Chen, Tianxiong Xiao, Chunye Liu, Zhiyao Xie, Wenqian Song, Qing Cissy Yu, Hongxing Fu, Xu Han, Taochen He, Wenquan Wang, Jianfeng Chen, Sheng Yan, Shaohua Song, Liang Liu, Yi Arial Zeng   +21 more
wiley   +1 more source

Glycosaminoglycans and Proteoglycans

Pharmaceuticals, 2018
In this editorial to MDPI Pharmaceuticals special issue “Glycosaminoglycans and Proteoglycans” we describe in outline the common structural features of glycosaminoglycans and the characteristics of proteoglycans, including the intracellular proteoglycan,
Vitor H. Pomin, Barbara Mulloy
doaj   +1 more source

Identification of Heparan Sulfate in Dilated Cardiomyopathy by Integrated Bioinformatics Analysis

Frontiers in Cardiovascular Medicine, 2022
ObjectivesHeparan sulfate (HS) forms heparan sulfate proteoglycans (HSPGs), such as syndecans (SDCs) and glypicans (GPCs), to perform biological processes in the mammals.
Wenyu Song, Fujian Lu, Zequan Ding, Liqi Huang, Kui Hu, Jinmiao Chen, Lai Wei   +6 more
doaj   +1 more source

A Hydrodynamic Bioreactor for High‐Yield Production of Extracellular Vesicles from Stem Cell Spheroids with Defined Cargo Profiling

Advanced Science, EarlyView.
This study harnesses hydrodynamic flows to generate, confine and stimulate stem cell spheroids, enabling the large‐scale production of extracellular vesicles (EVs). This innovative method not only streamlines spheroid formation and subsequent EV release in a single, integrated process, but also ensures the generation of EVs with enhanced biological ...
Solène Lenoir, Elliot Thouvenot, Giacomo Gropplero, Léonie Dec, Damarys Loew, Clotilde Théry, Jose E Perez, Claire Wilhelm   +7 more
wiley   +1 more source

Syndecan-3 in Inflammation and Angiogenesis

Frontiers in Immunology, 2020
Syndecans are a four member multifunctional family of cell surface molecules with diverse biological roles. Syndecan-3 (SDC3) is the largest of these, but in comparison to the other family members relatively little is known about this molecule. SDC3 null
Samantha Arokiasamy, Michaela J. M. Balderstone, Giulia De Rossi, James R. Whiteford   +3 more
doaj   +1 more source