Results 91 to 100 of about 6,494,075 (356)

The metabolic syndrome and total and cardiovascular disease mortality in middle-aged men.

Journal of the American Medical Association (JAMA), 2002
CONTEXT The metabolic syndrome, a concurrence of disturbed glucose and insulin metabolism, overweight and abdominal fat distribution, mild dyslipidemia, and hypertension, is associated with subsequent development of type 2 diabetes mellitus and ...
H. Lakka, D. Laaksonen, T. Lakka, L. Niskanen, E. Kumpusalo, J. Tuomilehto, J. Salonen   +6 more
semanticscholar   +1 more source

Re-evaluation of waist circumference in metabolic syndrome: a comparison between Japanese men and women [PDF]

, 2007
We re-evaluated the criteria for waist circumference to predict the accumulation of the components of metabolic syndrome. We used data for 3,185 Japanese, aged 20-79 years.
Makino, Hirofumi, Matsumoto, Sumiko, Miyatake, Nobuyuki, Nishikawa, Hidetaka, Numata, Takeyuki, Wada, Jun   +5 more
core   +1 more source

Spot‐14 and its paralog Spot‐14R regulate expression of metabolic and thermogenic pathway genes in murine brown and beige adipocytes

FEBS Letters, EarlyView.
Spot‐14 and Spot‐14R play distinct roles in regulating metabolism in brown and beige adipocytes. While both influence lipid and glucose pathways, Spot‐14 uniquely controls thermogenic gene expression. This dual regulation balances energy storage and heat production, highlighting potential therapeutic targets for obesity and metabolic disorders. Spot 14
Lidia Itzel Castro‐Rodríguez, Cristina Velez‐delValle, Claudia Patricia Hernández‐Mosqueira, Walid Kuri‐Harcuch   +3 more
wiley   +1 more source

Leopard syndrome [PDF]

Orphanet Journal of Rare Diseases, 2008
LEOPARD syndrome (LS, OMIM 151100) is a rare multiple congenital anomalies condition, mainly characterized by skin, facial and cardiac anomalies. LEOPARD is an acronym for the major features of this disorder, including multiple Lentigines, ECG conduction abnormalities, Ocular hypertelorism, Pulmonic stenosis, Abnormal genitalia, Retardation of growth ...
SARKOZY A, DIGILIO MC, DALLA PICCOLA, Bruno   +2 more
openaire   +5 more sources

The Cardioprotective Potential of Herbal Formulas in Myocardial Infarction-Induced Heart Failure through Inhibition of JAK/STAT3 Signaling and Improvement of Cardiac Function

Pharmaceuticals
Myocardial infarction (MI) is a leading cause of heart failure, characterized by adverse cardiac remodeling. This study evaluated the cardioprotective potential of Dohongsamul-tang (DHT), a traditional Korean herbal formula, in a rat model of MI-induced ...
Youn-Jae Jang, Hye-Yoom Kim, Se-Won Na, Mi-Hyeon Hong, Jung-Joo Yoon, Ho-Sub Lee, Dae-Gill Kang   +6 more
doaj   +1 more source

Gene-Gene Interaction between APOA5 and USF1: Two Candidate Genes for the Metabolic Syndrome [PDF]

, 2009
Objective: The metabolic syndrome, a major cluster of risk factors for cardiovascular diseases, shows increasing prevalence worldwide. Several studies have established associations of both apolipoprotein A5 (APOA5) gene variants and upstream stimulatory ...
, Baumert, Jens, Grallert, Harald, Herder, Christian, Holzapfel, Christina, Illig, Thomas, Klingenspor, Martin, Klopp, Norman, Meisinger, Christa, Rathmann, Wolfgang, Singmann, Paula, Wichmann, H.-Erich   +11 more
core   +2 more sources

Surfaceome: a new era in the discovery of immune evasion mechanisms of circulating tumor cells

Molecular Oncology, EarlyView.
In the era of immunotherapies, many patients either do not respond or eventually develop resistance. We propose to pave the way for proteomic analysis of surface‐expressed proteins called surfaceome, of circulating tumor cells. This approach seeks to identify immune evasion mechanisms and discover potential therapeutic targets. Circulating tumor cells (
Doryan Masmoudi, Jérome Vialaret, Christophe Hirtz, Catherine Alix‐Panabières   +3 more
wiley   +1 more source

Reed's syndrome

Indian Journal of Dermatology, 2018
Multiple cutaneous and uterine leiomyomatosis (MCUL), also known as Reed's syndrome, is a rare genodermatosis, with an autosomal dominant pattern of inheritance. It results from a germline heterozygous mutation of fumarate hydratase gene, that is classified as a tumor suppressor gene.
Almeida, FT, Santos, R P, Carvalho, SD, Brito, C   +3 more
openaire   +5 more sources

Variegated overexpression of chromosome 21 genes reveals molecular and immune subtypes of Down syndrome

Nature Communications
Individuals with Down syndrome, the genetic condition caused by trisomy 21, exhibit strong inter-individual variability in terms of developmental phenotypes and diagnosis of co-occurring conditions.
Micah G. Donovan, Neetha P. Eduthan, Keith P. Smith, Eleanor C. Britton, Hannah R. Lyford, Paula Araya, Ross E. Granrath, Katherine A. Waugh, Belinda Enriquez Estrada, Angela L. Rachubinski, Kelly D. Sullivan, Matthew D. Galbraith, Joaquin M. Espinosa   +12 more
doaj   +1 more source

Sudden Caffeine Withdrawal Triggers Migraine—A Randomized Controlled Trial

Frontiers in Neurology, 2020
Objective: Assessing the effects of caffeine withdrawal on migraine.Background: The effects of caffeine withdrawal on migraineurs are at large unknown.Methods: This was a randomized, double-blind, crossover study (NCT03022838), designed to enroll 80 ...
Karl B. Alstadhaug, Karl B. Alstadhaug, Hilde Karen Ofte, Kai Ivar Müller, Kai Ivar Müller, Anna P. Andreou, Anna P. Andreou   +6 more
doaj   +1 more source