Results 61 to 70 of about 169,807 (345)

Spinodal instabilities within BUU approach [PDF]

, 1995
Using a recently developed method for the inclusion of fluctuation in the BUU dynamics, we study the self-consistent propagation of inherent thermal noise of unstable nuclear matter.
C.J. Pethick, D. Kiderlen, E. Suraud, G. F. Burgio, G.F. Burgio, G.F. Burgio, G.F. Burgio, H. Risken, J. Randrup, L.G. Moretto, M. Baldo, M. Baldo, M. Colonna, M. Colonna, M. Colonna, M. Colonna, M. Colonna, M. Gong, M. Suzuki, M. Suzuki, R. Donangelo, R. Donangelo, S. Ayik, S. Ayik, S. Chattopadhyay, S. Chattopadhyay, W. Bauer, W.U. Schröder   +27 more
core   +3 more sources

Structural biology of ferritin nanocages

FEBS Letters, EarlyView.
Ferritin is a conserved iron‐storage protein that sequesters iron as a ferric mineral core within a nanocage, protecting cells from oxidative damage and maintaining iron homeostasis. This review discusses ferritin biology, structure, and function, and highlights recent cryo‐EM studies revealing mechanisms of ferritinophagy, cellular iron uptake, and ...
Eloise Mastrangelo, Flavio Di Pisa
wiley   +1 more source

Phenylboronic Acids Probing Molecular Recognition against Class A and Class C β-lactamases

Antibiotics, 2019
Worldwide dissemination of pathogens resistant to almost all available antibiotics represent a real problem preventing efficient treatment of infectious diseases. Among antimicrobial used in therapy, β-lactam antibiotics represent 40% thus playing a
Pasquale Linciano, Mattia Vicario, Ivana Kekez, Pierangelo Bellio, Giuseppe Celenza, Isabel Martín-Blecua, Jesús Blázquez, Laura Cendron, Donatella Tondi   +8 more
doaj   +1 more source

PARP inhibitors elicit distinct transcriptional programs in homologous recombination competent castration‐resistant prostate cancer

Molecular Oncology, EarlyView.
PARP inhibitors are used to treat a small subset of prostate cancer patients. These studies reveal that PARP1 activity and expression are different between European American and African American prostate cancer tissue samples. Additionally, different PARP inhibitors cause unique and overlapping transcriptional changes, notably, p53 pathway upregulation.
Moriah L. Cunningham, Jasibel Vasquez‐Gonzalez, Samantha M. Barnada, Salome Tchotorlishvili, Latese Jones, Ryan Maguire, Genevieve Lewis, Kinza Rizwan, Jenny Deng, Salma Koachar, Drithi Patel, Hailey Shankle, Tessa Mulders, Namra Ajmal, Charalambos Solomides, Emad S. Alnemri, Teresa F. Alnemri, Ayesha A. Shafi, Leonard G. Gomella, Wm Kevin Kelly, Steven B. McMahon, Matthew J. Schiewer   +21 more
wiley   +1 more source

The role of detoxifying enzymes in the resistance of the cowpea aphid (Aphis craccivora Koch) to thiamethoxam

Journal of Plant Protection Research, 2016
The cowpea aphid (Aphis craccivora Koch) is considered a serious insect pest attacking several crops. We carried out biochemical studies to elucidate the role of the metabolising enzymes in conferring resistance to thiamethoxam, in two strains (resistant
Abdallah Ibrahim Saleh, Abou-Yousef Hala Mohamed, Fouad Eman Atef, Kandil Mohammed Abd El-Hady   +3 more
doaj   +1 more source

Decontamination of oil-polluted soils: Power of electronic bioinformatic databases

Журнал інженерних наук, 2022
The main idea was to solve the problem related to oil contamination of soil using bioremediation with bioaugmentation with modeled microorganism strains.
Ablieieva I. Yu., Plyatsuk L. D., Liu T., Berezhna I. O., Yanchenko I. O.   +4 more
doaj   +1 more source

Inhibition of CDK9 enhances AML cell death induced by combined venetoclax and azacitidine

Molecular Oncology, EarlyView.
The CDK9 inhibitor AZD4573 downregulates c‐MYC and MCL‐1 to induce death of cytarabine (AraC)‐resistant AML cells. This enhances VEN + AZA‐induced cell death significantly more than any combination of two of the three drugs in AraC‐resistant AML cells.
Shuangshuang Wu, Jianlei Zhao, Aaban Asfar Azmi, Avanti Gupte, Jenna Thibodeau, Shuang Liu, Jinli Yang, Guan Wang, Holly Edwards, Lisa A. Polin, Juiwanna Kushner, Sijana H. Dzinic, Kathryn White, Julie Boerner, Maik Hüttemann, Jay Yang, Yue Wang, Jeffrey W. Taub, Yubin Ge   +18 more
wiley   +1 more source

Predictors of response and rational combinations for the novel MCL‐1 inhibitor MIK665 in acute myeloid leukemia

Molecular Oncology, EarlyView.
This study characterizes the responses of primary acute myeloid leukemia (AML) patient samples to the MCL‐1 inhibitor MIK665. The results revealed that monocytic differentiation is associated with MIK665 sensitivity. Conversely, elevated ABCB1 expression is a potential biomarker of resistance to the treatment, which can be overcome by the combination ...
Joseph Saad, Rhiannon Newman, Elmira Khabusheva, Sofia Aakko, Eric Durand, Mahesh Tambe, Heikki Kuusanmäki, Alun Parsons, Juho J. Miettinen, Komal Kumar Javarappa, Ezgi June Olgac, Nemo Ikonen, Mika Kontro, Kimmo Porkka, Heiko Maacke, Janghee Woo, Ensar Halilovic, Caroline A. Heckman   +17 more
wiley   +1 more source

Glutathione and the Antioxidant Potential of Binary Mixtures with Flavonoids: Synergisms and Antagonisms

Molecules, 2013
Polyphenols are able to trap free radicals, which contributes to their known antioxidant capacity. In plant extracts, these secondary metabolites may act in concert, in a way that their combined activities will be superior to their individual effects ...
Patrícia Valentão, Paula B. Andrade, Renato B. Pereira, Andreia Costa, Carla Sousa   +4 more
doaj   +1 more source

Anti-Biofilm Inhibitory Synergistic Effects of Combinations of Essential Oils and Antibiotics

Antibiotics, 2020
In recent years, the increase of bacteria antibiotic- resistance has been a severe problem for public health. A useful solution could be to join some phytochemicals naturally present in essential oils (EOs) to the existing antibiotics, with the aim to ...
Antonio Rosato, Sabina Sblano, Lara Salvagno, Alessia Carocci, Maria Lisa Clodoveo, Filomena Corbo, Giuseppe Fracchiolla   +6 more
doaj   +1 more source