Bao-An Chen1, Yong-Yuan Dai1, Xue-Mei Wang2, Ren-Yun Zhang2, Wen-Lin Xu3, Hui-Ling Shen3, Feng Gao1, Qian Sun1, Xiao-Jing Deng1, Jia-hua Ding1, Chong Gao1, Yun-Yu Sun1, Jian Cheng1, Jun Wang1, Gang Zhao1, Ning-Na Chen11Department of Hematology, The ...
Bao-An Chen +5 more
doaj
Case-based reasoning: The marriage of knowledge base and data base [PDF]
The coupling of data and knowledge has a synergistic effect when building an intelligent data base. The goal is to integrate the data and knowledge almost to the point of indistinguishability, permitting them to be used interchangeably. Examples given in
Casadaban, Cyprian, Pulaski, Kirt
core +1 more source
Disordered but rhythmic—the role of intrinsic protein disorder in eukaryotic circadian timing
Unstructured domains known as intrinsically disordered regions (IDRs) are present in nearly every part of the eukaryotic core circadian oscillator. IDRs enable many diverse inter‐ and intramolecular interactions that support clock function. IDR conformations are highly tunable by post‐translational modifications and environmental conditions, which ...
Emery T. Usher, Jacqueline F. Pelham
wiley +1 more source
Background: Antibiotic resistance is a life threating problem and the need for an alternative is increasing worldwide. Objective of this study is: Detecting the combination effect of AuNps with Amoxicillin/clavulanate (AMC) antibiotic against ...
Marwa H. al-khafaji, Mohammed H. Hashim
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Protein pyrophosphorylation by inositol pyrophosphates — detection, function, and regulation
Protein pyrophosphorylation is an unusual signaling mechanism that was discovered two decades ago. It can be driven by inositol pyrophosphate messengers and influences various cellular processes. Herein, we summarize the research progress and challenges of this field, covering pathways found to be regulated by this posttranslational modification as ...
Sarah Lampe +3 more
wiley +1 more source
Synergistic effect of Mannich base and sodium tungstate as corrosion inhibition for N80 steel
The corrosion inhibition effect and adsorption behavior for N80 steel in HCl solution were investigated by using electrochemical method and scanning electron microscope, meanwhile, the corrosion inhibition mechanism of inhibitors was analysed from the ...
WANG Yun +3 more
doaj +1 more source
Synthesis and Evaluation of Methyl 4-(7-Hydroxy-4,4,8-Trimethyl-3-Oxabicyclo[3.3.1]Nonan-2-yl)Benzoate as an Antileishmanial Agent and Its Synergistic Effect with Miltefosine [PDF]
Prachi Bhalla +4 more
openalex +1 more source
Synergistic Effect of Serotonin 1A and Serotonin 1B/D Receptor Agonists in the Treatment of L-DOPA-Induced Dyskinesia in 6-Hydroxydopamine-Lesioned Rats [PDF]
Mikael S. Thomsen +4 more
openalex +1 more source
The role of histone modifications in transcription regulation upon DNA damage
This review discusses the critical role of histone modifications in regulating gene expression during the DNA damage response (DDR). By modulating chromatin structure and recruiting repair factors, these post‐translational modifications fine‐tune transcriptional programmes to maintain genomic stability.
Angelina Job Kolady, Siyao Wang
wiley +1 more source
Background Tetrahydromagnolol (THM) is a compound isolated from Magnolia officinalis with unique chemical structure and composition. However, its anticancer effect of THM and the underlying molecular mechanisms remain unclear.
Xiaoqing Gu +7 more
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