Results 231 to 240 of about 957,593 (356)

Targeting lipogenesis promotes the synergistic effect of the selective HDAC6 inhibitor ITF3756 with bortezomib in colon cancer cells. [PDF]

Front Pharmacol
Franzò M, Zichittella C, Di Liberto D, Pratelli G, Affranchi F, Notaro A, Giuliano M, Emanuele S.   +7 more
europepmc   +1 more source

Dual targeting of RET and SRC synergizes in RET fusion‐positive cancer cells

Molecular Oncology, EarlyView.
Despite the strong activity of selective RET tyrosine kinase inhibitors (TKIs), resistance of RET fusion‐positive (RET+) lung cancer and thyroid cancer frequently occurs and is mainly driven by RET‐independent bypass mechanisms. Son et al. show that SRC TKIs significantly inhibit PAK and AKT survival signaling and enhance the efficacy of RET TKIs in ...
Juhyeon Son, Lily L. Remsing Rix, Bin Fang, Eric A. Welsh, Nicole V. Bremer, Valentina Foglizzo, Paola Roa, Nickole Sigcha‐Coello, Yi Liao, Eric B. Haura, Alexander Drilon, John M. Koomen, Emiliano Cocco, Uwe Rix   +13 more
wiley   +1 more source

Prolonged Protection of Copper in Acidic Media Through the Synergistic Effect of Fat-Soluble Vitamins. [PDF]

Materials (Basel)
Fuchs-Godec R.
europepmc   +1 more source

Cis‐regulatory and long noncoding RNA alterations in breast cancer – current insights, biomarker utility, and the critical need for functional validation

Molecular Oncology, EarlyView.
The noncoding region of the genome plays a key role in regulating gene expression, and mutations within these regions are capable of altering it. Researchers have identified multiple functional noncoding mutations associated with increased cancer risk in the genome of breast cancer patients.
Arnau Cuy Saqués, Aracele Martinez‐Mendez, John Crown, Alex Eustace   +3 more
wiley   +1 more source

Detection of Inosine Monophosphate and the Umami Synergistic Effect Using a Taste Sensor with a Surface-Modified Membrane. [PDF]

Molecules
Otsuka S, Koshi M, Onodera T, Yatabe R, Matsui T, Toko K.   +5 more
europepmc   +1 more source

Methylation biomarkers can distinguish pleural mesothelioma from healthy pleura and other pleural pathologies

Molecular Oncology, EarlyView.
We developed and validated a DNA methylation–based biomarker panel to distinguish pleural mesothelioma from other pleural conditions. Using the IMPRESS technology, we translated this panel into a clinically applicable assay. The resulting two classifier models demonstrated excellent performance, achieving high AUC values and strong diagnostic accuracy.
Janah Vandenhoeck, Nele De Meulenaere, Thomas Vanpoucke, Joe Ibrahim, Dieter Peeters, Suresh Krishan Yogeswaran, Wen Wen, Paul Van Schil, Jeroen M. H. Hendriks, Jo Raskin, Jan van Meerbeeck, Guy Van Camp, Ken Op de Beeck   +12 more
wiley   +1 more source

Synergistic effect of early enteral and parenteral nutrition on immune and nutritional recovery following gastric cancer surgery. [PDF]

Front Surg
Tao J, Du X, Xu H, Dai L, Zhang C, Gao W, Huang S, Wang Y, Sun J, Zhao W.   +9 more
europepmc   +1 more source

Correction to: The synergistic effect of plant growth regulators and polyamines on regeneration of Nothapodytes foetida, and assessment of genetic fidelity using ISSR and SCoT markers [PDF]

A. Srividya, Rathnaprabha Dharavath
openalex   +1 more source

Synergistic effect of hypoxia and TNF-α on production of PAI-1 in human proximal renal tubular cells [PDF]

, 2005
Xuan Li, Hideki Kimura, Kiichi Hirota, Kenji Kasuno, Kunio Torii, Toshiharu Okada, Hisanori Kurooka, Yoshifumi Yokota, Haruyoshi Yoshida   +8 more
openalex   +1 more source

Strength through diversity: how cancers thrive when clones cooperate

Molecular Oncology, EarlyView.
Intratumor heterogeneity can offer direct benefits to the tumor through cooperation between different clones. In this review, Kuiken et al. discuss existing evidence for clonal cooperativity to identify overarching principles, and highlight how novel technological developments could address remaining open questions.
Marije C. Kuiken, Maartje Witsen, Emile E. Voest, Krijn K. Dijkstra   +3 more
wiley   +1 more source