Results 251 to 260 of about 957,593 (356)

Potential therapeutic targeting of BKCa channels in glioblastoma treatment

Molecular Oncology, EarlyView.
This review summarizes current insights into the role of BKCa and mitoBKCa channels in glioblastoma biology, their potential classification as oncochannels, and the emerging pharmacological strategies targeting these channels, emphasizing the translational challenges in developing BKCa‐directed therapies for glioblastoma treatment.
Kamila Maliszewska‐Olejniczak, Karolina Pytlak, Sandra Jaworowska, Bogusz Kulawiak, Piotr Bednarczyk   +4 more
wiley   +1 more source

The Synergistic Effect of Sodium Hypochlorite (NaClO) and Organosilicone Adjuvant Enhances the Inhibition and Oxidative Damage in <i>Cladophora</i> sp. [PDF]

Biology (Basel)
Zhao L, Tan C, Tang Y, Zhang Z, Guo L, Yao G, Dai Q, Cheng Y, Qian C.   +8 more
europepmc   +1 more source

LINC01116, a hypoxia‐lncRNA marker of pathological lymphangiogenesis and poor prognosis in lung adenocarcinoma

Molecular Oncology, EarlyView.
The LINC01116 long noncoding RNA is induced by hypoxia and associated with poor prognosis and high recurrence rates in two cohorts of lung adenocarcinoma patients. Here, we demonstrate that besides its expression in cancer cells, LINC01116 is markedly expressed in lymphatic endothelial cells of the tumor stroma in which it participates in hypoxia ...
Marine Gautier‐Isola, Rafael Lopes Goncalves, Marin Truchi, Caroline Lacoux, Célia Scribe, Hugo Cadis, Laetitia Guardini, Sophie Bekisz, Marius Ilié, Paul Hofman, Georges Vassaux, Bernard Mari, Roger Rezzonico   +12 more
wiley   +1 more source

ATF4‐mediated stress response as a therapeutic vulnerability in chordoma

Molecular Oncology, EarlyView.
We screened 5 chordoma cell lines against 100+ inhibitors of epigenetic and metabolic pathways and kinases and identified halofuginone, a tRNA synthetase inhibitor. Mechanistically halofuginone induces an integrated stress response, with eIF2alpha phosphorylation, activation of ATF4 and its target genes CHOP, ASNS, INHBE leading to cell death ...
Lucia Cottone, James Dunford, Eleanor Calcutt, Vicki Gamble, Filiz Senbabaoglu Aksu, Lorena Ligammari, Georgina Wherry, Giorgia Gaeta, John C. Christianson, Adrienne M. Flanagan, Udo Oppermann, Adam P. Cribbs   +11 more
wiley   +1 more source

Evaluation of Synergistic Effect of Colistin with Levofloxacin and Meropenem against Multidrug-resistant <i>Acinetobacter baumannii</i>. [PDF]

J Res Pharm Pract
Shafiee F, Soltani R, Momenzadeh M.
europepmc   +1 more source

A novel 5-FU/rGO/Bce hybrid hydrogel shell on a tumor cell: one-step synthesis and synergistic chemo/photo-thermal/photodynamic effect

, 2017
Ying Yang, Lin Zhu, Feng Xia, Baoyou Gong, Anjian Xie, Shikuo Li, Fangzhi Huang, Shaohua Wang, Yuhua Shen, David T. Weaver   +9 more
openalex   +2 more sources

Developing evidence‐based, cost‐effective P4 cancer medicine for driving innovation in prevention, therapeutics, patient care and reducing healthcare inequalities

Molecular Oncology, EarlyView.
The cancer problem is increasing globally with projections up to the year 2050 showing unfavourable outcomes in terms of incidence and cancer‐related deaths. The main challenges are prevention, improved therapeutics resulting in increased cure rates and enhanced health‐related quality of life.
Ulrik Ringborg, Joachim von Braun, Julio Celis, Anton Berns, Michael Baumann, Tit Albreht, Nancy Abou‐Zeid, Vanderlei Bagnato, Christian Brandts, Chien‐Jen Chen, Massimiliano di Pietro, Manjit Dosanjh, Thomas Dubois, Alexander Eggermont, Angelika Eggert, Ingemar Ernberg, Sara Faithfull, Johannes Förner, Stefan Fröhling, Manuel Heitor, Leroy Hood, Wei Jiang, Bengt Jönsson, Ravi Kannan, Maria Leptin, Su Li, Peter Lindgren, Douglas Lowy, Jun Ma, Alex Markham, Péter Nagy, Simon Oberst, M. Iqbal Parker, Danielle Rodin, Kevin Ryan, Joachim Schüz, Richard Sullivan, Josep Tabernero, Peter Turkson, Oliver Várhelyi, Harold Varmus, Chijie Wang, Elisabete Weiderpass, Nils Wilking   +43 more
wiley   +1 more source

Synergistic Effect of Composite Chitosan/Phenylalanine Edible Coating on the Postharvest Bioactive Composition of Mandarin Fruit. [PDF]

Food Sci Nutr
Jurić S, Vuković M, Bureš MS, Stracenski KS, Donsì F, Bandić LM.   +5 more
europepmc   +1 more source

Synergistic Effect of Triptolide and Tacrolimus on Rat Cardiac Allotransplantation

, 2004
LI Ru-zheng, Kenji Takazawa, Hiromasa Suzuki, Akifusa Hariya, Taira Yamamoto, Satoshi Matsushita, Hitoshi Hirose, Atsushi Amano   +7 more
openalex   +2 more sources