Results 41 to 50 of about 778,777 (287)

Organoids in pediatric cancer research

open access: yesFEBS Letters, EarlyView.
Organoid technology has revolutionized cancer research, yet its application in pediatric oncology remains limited. Recent advances have enabled the development of pediatric tumor organoids, offering new insights into disease biology, treatment response, and interactions with the tumor microenvironment.
Carla Ríos Arceo, Jarno Drost
wiley   +1 more source

Formation of a change management model in the company

open access: yesПутеводитель предпринимателя
In the context of rapid changes in the external environment, organizations are faced with the need to effectively manage transformation processes in order to ensure competitiveness and achieve strategic goals.
G. R. Minasbekyan, T. V. Suvorova
doaj   +1 more source

Comfortable urban environment as a basis for social adaptation of people with disabilities

open access: yesПутеводитель предпринимателя, 2023
An urban environment with comfort zones is an important condition of modern human life, in particular, it is directly related to people who have limited mobility.
V. I. Khabarov, S. V. Bruev
doaj   +1 more source

Reciprocal control of viral infection and phosphoinositide dynamics

open access: yesFEBS Letters, EarlyView.
Phosphoinositides, although scarce, regulate key cellular processes, including membrane dynamics and signaling. Viruses exploit these lipids to support their entry, replication, assembly, and egress. The central role of phosphoinositides in infection highlights phosphoinositide metabolism as a promising antiviral target.
Marie Déborah Bancilhon, Bruno Mesmin
wiley   +1 more source

Managing the company’s economic sustainability through website usability

open access: yesУченые записки Российской академии предпринимательства
In today’s dynamic world, any company is concerned about maintaining its market position, increasing economic stability and competitiveness. It is known that today almost all companies have a website.
D. A. Timonov, T. V. Suvorova
doaj   +1 more source

When none of us perform better than all of us together: the role of analogical decision rules in groups [PDF]

open access: yes, 2014
During social interactions, groups develop collective competencies that (ideally) should assist groups to outperform average standalone individual members (weak cognitive synergy) or the best performing member in the group (strong cognitive synergy).
Curseu, Petru   +3 more
core   +3 more sources

Spatiotemporal and quantitative analyses of phosphoinositides – fluorescent probe—and mass spectrometry‐based approaches

open access: yesFEBS Letters, EarlyView.
Fluorescent probes allow dynamic visualization of phosphoinositides in living cells (left), whereas mass spectrometry provides high‐sensitivity, isomer‐resolved quantitation (right). Their synergistic use captures complementary aspects of lipid signaling. This review illustrates how these approaches reveal the spatiotemporal regulation and quantitative
Hiroaki Kajiho   +3 more
wiley   +1 more source

PICALM::MLLT10 translocated leukemia

open access: yesFEBS Letters, EarlyView.
This comprehensive review of PICALM::MLLT10 translocated acute leukemia provides an in‐depth review of the structure and function of CALM, AF10, and the fusion oncoprotein (1). The multifaceted molecular mechanisms of oncogenesis, including nucleocytoplasmic shuttling (2), epigenetic modifications (3), and disruption of endocytosis (4), are then ...
John M. Cullen   +7 more
wiley   +1 more source

Digital transformation of business during the Fourth Industrial Revolution

open access: yesПутеводитель предпринимателя, 2023
The introduction of innovative technologies, optimization of output and fundamental changes in the industrial sphere force manufacturing enterprises to find the latest sources of development and increase productivity.
V. I. Khabarov, K. V. Lukashin
doaj   +1 more source

Inhibiting stearoyl‐CoA desaturase suppresses bone metastatic prostate cancer by modulating cellular stress, mTOR signaling, and DNA damage response

open access: yesFEBS Letters, EarlyView.
Bone metastasis in prostate cancer (PCa) patients is a clinical hurdle due to the poor understanding of the supportive bone microenvironment. Here, we identify stearoyl‐CoA desaturase (SCD) as a tumor‐promoting enzyme and potential therapeutic target in bone metastatic PCa.
Alexis Wilson   +7 more
wiley   +1 more source

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