Results 51 to 60 of about 291,766 (265)

Interactive Forms in Training Sessions as a Factor in Motivating Entrepreneurship Students to Study the Culture of Speech

Современная конкуренция, 2022
The article considers interactive forms of organizing training sessions in the discipline “Russian language and culture of speech” as part of professionally oriented training of the students of “Entrepreneurship” direction.
Elena V. Ushakova, Elena O. Sycheva
doaj   +1 more source

Infrastructures for healthcare: From synergy to reverse synergy

Health Informatics Journal, 2016
The Danish General Practitioners Database has over more than a decade developed into a large-scale successful information infrastructure supporting medical research in Denmark. Danish general practitioners produce the data, by coding all patient consultations according to a certain set of classifications, on the entire Danish population.
Langhoff, Tue Odd, Amstrup, Mikkel Hvid, Mørck, Peter, Bjørn, Pernille   +3 more
openaire   +3 more sources

An epithelial GPR35 isoform supports tumor‐associated transcriptional and metabolic phenotypes

FEBS Letters, EarlyView.
GPR35 generates two functionally distinct isoforms with previously unresolved roles. GPR35‐short mediates immune‐cell chemotaxis, while GPR35‐long is enriched in colorectal cancer epithelium, where it supports increased metabolism, proliferation, and tumor‐associated transcriptional programs.
Jørgen D. Rønneberg, Martine Hjeltnes, Josephine Krieger, Joshua E. Elias, Maria Stensland, Kristian Holm, Xiaojun Jiang, Chuki Khangsar, Tuula A. Nyman, Arthur Kaser, Johannes R. Hov, Tom H. Karlsen, Nicole C. Kaneider, Frode L. Jahnsen, Georg Schneditz   +14 more
wiley   +1 more source

Features of Introducing Agile Methodologies in the Software Development Process for Telecommunications Services

Современная конкуренция
The article discusses the features of the introduction of agile methodologies in the process of software development (hereinafter referred to as software) in the field of telecommunications services.
Alexander Yu. Anisimov, Alexander E. Trubin, Elena N. Tokmakova, Elena V. Filimonova   +3 more
doaj   +1 more source

Dimethyl fumarate combined with cisplatin at subcytotoxic doses sensitizes cervical cancer toward ferroptosis and apoptosis through GSH restriction and p53 (re)activation

Molecular Oncology, EarlyView.
Dimethyl fumarate (DMF) reduces growth of HPV‐positive cervical cancer spheroids and induces ferroptosis in cervical cancer cells via blocking SLC7A11/Glutathione (GSH) axis. Combination of subcytotoxic doses of DMF and cisplatin (CDDP) further suppresses spheroid growth and drives cell death in 2D culture models.
Carolina Punziano, Giuseppina Minopoli, Simona Romano, Laura Marrone, Katia Aquilano, Maria Lina Tornesello, Raffaella Faraonio   +6 more
wiley   +1 more source

A systematic approach to identify therapeutic effects of natural products based on human metabolite information

BMC Bioinformatics, 2018
Background Natural products have been widely investigated in the drug development field. Their traditional use cases as medicinal agents and their resemblance of our endogenous compounds show the possibility of new drug development. Many researchers have
Kyungrin Noh, Sunyong Yoo, Doheon Lee
doaj   +1 more source

IMPDH inhibition enhances cytarabine efficacy in SAMHD1‐expressing leukaemia cells via guanine nucleotide depletion

Molecular Oncology, EarlyView.
Cytarabine is a key therapy for acute myeloid leukaemia (AML), but its efficacy is limited by the dNTPase SAMHD1, which hydrolyses its active metabolite. Screening nucleotide biosynthesis inhibitors revealed that IMPDH inhibitors selectively sensitise SAMHD1‐proficient AML cells to cytarabine.
Miriam Yagüe‐Capilla, Christopher Dirks, Caroline Eiden, Sonja K. Fesenmayer, Femke M. Hormann, Yolande Klootsema, Ingrid Lilienthal, Si Min Zhang, Nikolas Herold, Sean G. Rudd   +9 more
wiley   +1 more source

The Application of Stress Case Method in Teaching Entrepreneurship as an Competitive Strength of University Educational Operations

Современная конкуренция
The article studies the use of interactive methods of teaching professional activity in educational programs for entrepreneurs, indicating the use of the stress case method, which contributes to the formation of flexible and adaptive skills in students ...
Elena V. Alekseeva, Anna Yu. Pogorelova, Olga N. Potapova, Diana A. Filippova   +3 more
doaj   +1 more source

Sibling Synergy

Stem Cells Translational Medicine, 2014
The sister journals Stem Cells and Stem Cells Translational Medicine have synergistic roles, although there is often considerable overlap in content between them. Whereas Stem Cells is primarily concerned with advancing basic knowledge of mechanism and function, Stem Cells Translational Medicine is geared toward the application of such advances for ...
openaire   +2 more sources

Stimulator of interferon genes agonist augmented antitumor immunity of osimertinib in Egfr‐mutated lung cancer

Molecular Oncology, EarlyView.
Combining osimertinib with the STING agonist ADU‐S100 activates innate and adaptive immunity to overcome the non‐inflamed microenvironment of Egfr‐mutant lung cancer. This combination increases NK and CD8+ T‐cell infiltration, associated with activation of the STING‐IRF3 pathway and local immunogenic cell death.
Jun Nishimura, Tadahiro Kuribayashi, Johannes Brägelmann, Sachi Okawa, Masataka Taoka, Shunta Mori, Tomoka Nishimura, Takaaki Tanaka, Go Makimoto, Kiichiro Ninomiya, Kammei Rai, Eiki Ichihara, Ryohei Katayama, Katsuyuki Hotta, Masahiro Tabata, Yosuke Togashi, Yoshinobu Maeda, Martin L. Sos, Katsuyuki Kiura, Kadoaki Ohashi   +19 more
wiley   +1 more source