Results 61 to 70 of about 390,759 (303)

Analysis of the Use of Artificial Intelligence in ERP Systems: Potential and Real-World Implementation Experience

Современная конкуренция
Today, management faces problems associated with a significant change in the business environment. When managing an organization in such conditions, constantly changing data can force managers to postpone decision-making in search of greater analytical ...
Oleg V. Dorofeev, Natalia A. Rebus, Natalia N. Lyublinskaya, Elena V. Filimonova   +3 more
doaj   +1 more source

Structural insights into an engineered feruloyl esterase with improved MHET degrading properties

FEBS Letters, EarlyView.
A feruloyl esterase was engineered to mimic key features of MHETase, enhancing the degradation of PET oligomers. Structural and computational analysis reveal how a point mutation stabilizes the active site and reshapes the binding cleft, expading substrate scope.
Panagiota Karampa, Konstantinos Makryniotis, Theofani‐Iosifina Sousani, Evangelos Topakas, Vangelis Daskalakis, Maria Dimarogona   +5 more
wiley   +1 more source

Entrepreneurial time–management: evaluation of the effectiveness of online courses

Ученые записки Российской академии предпринимательства
The article presents the results of a comprehensive study of the adaptability of online courses on time–management for entrepreneurship. Based on the analysis of programs of leading Russian educational platforms (Netology, Skillbox, 4brain, etc.), a ...
T. Yu. Dobrovolskaya, A. A. Shavyrina, E. V. Alekseeva, A. Yu. Pogorelova   +3 more
doaj   +1 more source

Infrastructures for healthcare: From synergy to reverse synergy

Health Informatics Journal, 2016
The Danish General Practitioners Database has over more than a decade developed into a large-scale successful information infrastructure supporting medical research in Denmark. Danish general practitioners produce the data, by coding all patient consultations according to a certain set of classifications, on the entire Danish population.
Langhoff, Tue Odd, Amstrup, Mikkel Hvid, Mørck, Peter, Bjørn, Pernille   +3 more
openaire   +3 more sources

Hyperosmotic stress induces PARP1‐mediated HPF1‐dependent mono(ADP‐ribosyl)ation

FEBS Letters, EarlyView.
Sorbitol‐induced hyperosmotic stress rapidly induces reversible mono(ADP‐ribosyl)ation (MARylation) on PARP1 without the signs of genotoxic signaling. We show that PARP1 autoMARylation is HPF1 dependent and forms hydroxylamine‐resistant O‐glycosidic linkages.
Anna Georgina Kopasz, Mihály Mérey, Rebeka Vásárhelyi, Ramóna Pék, Victor Imburchia, László Henn, Adrián Kószó, Nicholas D. Lakin, Ivan Ahel, Sébastien Huet, Ágnes Czibula, Gyula Timinszky   +11 more
wiley   +1 more source

Developing System of Indicators Estimating Bankruptcy Possibility for Public Catering Organizations within the Frames of Crisis Management

Вестник Российского экономического университета имени Г. В. Плеханова, 2023
Developing the optimum crisis strategy depends mainly on the quality of analytical base, which is built in the process of finance analysis and diagnostics of organization bankruptcy. It is connected with organizations of public catering as well.
R. O. Malinovsky, A. Yu. Anisimov
doaj   +1 more source

Dimethyl fumarate combined with cisplatin at subcytotoxic doses sensitizes cervical cancer toward ferroptosis and apoptosis through GSH restriction and p53 (re)activation

Molecular Oncology, EarlyView.
Dimethyl fumarate (DMF) reduces growth of HPV‐positive cervical cancer spheroids and induces ferroptosis in cervical cancer cells via blocking SLC7A11/Glutathione (GSH) axis. Combination of subcytotoxic doses of DMF and cisplatin (CDDP) further suppresses spheroid growth and drives cell death in 2D culture models.
Carolina Punziano, Giuseppina Minopoli, Simona Romano, Laura Marrone, Katia Aquilano, Maria Lina Tornesello, Raffaella Faraonio   +6 more
wiley   +1 more source

EOSC-SYNERGY EU DELIVERABLE: D1.2 Diseemination and exploitation report

, 2020
Summary of dissemination and exploitation activities during the first half of the project.This document presents a summary of the dissemination and exploitation activities during the first half of the project.
Sokartara, Dimple, Andreozzi, Sergio, EOSC-SYNERGY, Campos, Isabel, Cauhe, Elisa   +4 more
core   +1 more source

IMPDH inhibition enhances cytarabine efficacy in SAMHD1‐expressing leukaemia cells via guanine nucleotide depletion

Molecular Oncology, EarlyView.
Cytarabine is a key therapy for acute myeloid leukaemia (AML), but its efficacy is limited by the dNTPase SAMHD1, which hydrolyses its active metabolite. Screening nucleotide biosynthesis inhibitors revealed that IMPDH inhibitors selectively sensitise SAMHD1‐proficient AML cells to cytarabine.
Miriam Yagüe‐Capilla, Christopher Dirks, Caroline Eiden, Sonja K. Fesenmayer, Femke M. Hormann, Yolande Klootsema, Ingrid Lilienthal, Si Min Zhang, Nikolas Herold, Sean G. Rudd   +9 more
wiley   +1 more source

Features of Introducing Agile Methodologies in the Software Development Process for Telecommunications Services

Современная конкуренция
The article discusses the features of the introduction of agile methodologies in the process of software development (hereinafter referred to as software) in the field of telecommunications services.
Alexander Yu. Anisimov, Alexander E. Trubin, Elena N. Tokmakova, Elena V. Filimonova   +3 more
doaj   +1 more source