Results 71 to 80 of about 390,759 (303)
BMC Bioinformatics, 2018 Background Natural products have been widely investigated in the drug development field. Their traditional use cases as medicinal agents and their resemblance of our endogenous compounds show the possibility of new drug development. Many researchers have
Kyungrin Noh, Sunyong Yoo, Doheon Lee
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Education Policy Instability in Nigeria and Implications for Educational Development in Nigeria
, 2023 Changes in educational policies are one of the major attributes of the Nigerian educational system. This paper examined the causes of educational policy instability in Nigeria and its implications on educational development.
Akinyode, Folasade +2 more
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Molecular Oncology, EarlyView.Targeted therapy was evaluated in SHH medulloblastoma using neuroepithelial stem cell (NES) and tumor‐derived NES‐like (tNES) models in 2D monolayers and 3D spheroids. PI3K, AKT, and CDK4/6 inhibitors had minimal effects in NES but markedly reduced viability and growth and induced apoptosis in tNES cells, revealing distinct therapeutic vulnerabilities.
Monika Lukoseviciute +4 more
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Hippo pathway at the crossroads of stemness and therapeutic resistance in breast cancer
Molecular Oncology, EarlyView.Dysregulation of the Hippo pathway drives nuclear accumulation of YAP/TAZ, activating stemness‐related transcriptional programs that sustain breast cancer stemness and fuel therapeutic resistance across subtypes, underscoring Hippo signaling as a targetable vulnerability. Figure created and edited with BioRender.com.
Giulia Schiavoni +11 more
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Современная конкуренцияThe article studies the use of interactive methods of teaching professional activity in educational programs for entrepreneurs, indicating the use of the stress case method, which contributes to the formation of flexible and adaptive skills in students ...
Elena V. Alekseeva +3 more
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Stem Cells Translational Medicine, 2014 The sister journals Stem Cells and Stem Cells Translational Medicine have synergistic roles, although there is often considerable overlap in content between them. Whereas Stem Cells is primarily concerned with advancing basic knowledge of mechanism and function, Stem Cells Translational Medicine is geared toward the application of such advances for ...
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, 2020 This study draws on theories of organizational inertia and relational view to examine how the pursuit of partnership synergy influences radical innovation in different technological contexts.
Ye, Jiangfeng +7 more
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Molecular Oncology, EarlyView.Beyond its role in immune evasion, this study identified that CD47 drives tumor‐intrinsic signaling in non‐small cell lung cancer (NSCLC). Transcriptomic profiling and functional studies revealed that CD47 regulates cell adhesion, migration, and metastasis through an ERK–EMT signaling axis.
Asa P.Y. Lau +8 more
wiley +1 more source
Molecular Oncology, EarlyView.We analyze cisplatin–DNA adducts (CDAs) and double‐strand breaks (DSBs) in a cell‐cycle‐dependent manner. We find that CDAs form similarly across all cell cycle phases. DSBs arise only in S‐phase. CDAs might not directly impair DSB repair, but S‐phase DSB lesions evolve in the presence of CDAs and disrupt repair in G2, also causing radiosensitization ...
Ye Qiu +10 more
wiley +1 more source
EOSC-SYNERGY EU DELIVERABLE: D3.2 First prototype of the Service Integration platform
, 2020 This deliverable describes the architecture, initial implementation and achievements of the first prototype of the quality assurance platform for EOSC software and services, the Software Quality Assurance as a Service (SQAaaS).
EOSC-SYNERGY +2 more
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