Results 51 to 60 of about 821,268 (334)

Resource base of Russian banks in modern conditions: factors of influence and actual tasks of funding

Ученые записки Российской академии предпринимательства, 2023
An important factor in the stable functioning of the banking sector is the quality of bank liabilities. The financial position of each credit institution, its liquidity, financial stability and efficiency, directly depend on the state of the resource ...
I. A. Sudarikova, E. V. Pushniak
doaj   +1 more source

Structural biology of ferritin nanocages

FEBS Letters, EarlyView.
Ferritin is a conserved iron‐storage protein that sequesters iron as a ferric mineral core within a nanocage, protecting cells from oxidative damage and maintaining iron homeostasis. This review discusses ferritin biology, structure, and function, and highlights recent cryo‐EM studies revealing mechanisms of ferritinophagy, cellular iron uptake, and ...
Eloise Mastrangelo, Flavio Di Pisa
wiley   +1 more source

PARP inhibitors elicit distinct transcriptional programs in homologous recombination competent castration‐resistant prostate cancer

Molecular Oncology, EarlyView.
PARP inhibitors are used to treat a small subset of prostate cancer patients. These studies reveal that PARP1 activity and expression are different between European American and African American prostate cancer tissue samples. Additionally, different PARP inhibitors cause unique and overlapping transcriptional changes, notably, p53 pathway upregulation.
Moriah L. Cunningham, Jasibel Vasquez‐Gonzalez, Samantha M. Barnada, Salome Tchotorlishvili, Latese Jones, Ryan Maguire, Genevieve Lewis, Kinza Rizwan, Jenny Deng, Salma Koachar, Drithi Patel, Hailey Shankle, Tessa Mulders, Namra Ajmal, Charalambos Solomides, Emad S. Alnemri, Teresa F. Alnemri, Ayesha A. Shafi, Leonard G. Gomella, Wm Kevin Kelly, Steven B. McMahon, Matthew J. Schiewer   +21 more
wiley   +1 more source

Analysis of factors influencing the use of agile methodologies in IT project management

Ученые записки Российской академии предпринимательства
In the context of high uncertainty and rapid change in the field of information technology, the effective application of agile project management methodologies is becoming increasingly relevant.
G. Y. Postnikov, A. G. Dmitriev
doaj   +1 more source

Synergy of multifrequency studies from observations of NGC6334I [PDF]

, 2008
We combine multifrequency observations from the millimeter to near infrared wavelengths that demonstrate the spatial distributions of H2, CO, and NH3 emission, which are all manifestations of various shocks driven by outflows of deeply embedded sources ...
Beuther, Henrik, Brogan, Crystal L, Hunter, Todd R, Leurini, Silvia, Menten, Karl M, Seifahrt, Andreas, Stecklum, Bringfried, Thorwirth, Sven   +7 more
core   +1 more source

Inhibition of CDK9 enhances AML cell death induced by combined venetoclax and azacitidine

Molecular Oncology, EarlyView.
The CDK9 inhibitor AZD4573 downregulates c‐MYC and MCL‐1 to induce death of cytarabine (AraC)‐resistant AML cells. This enhances VEN + AZA‐induced cell death significantly more than any combination of two of the three drugs in AraC‐resistant AML cells.
Shuangshuang Wu, Jianlei Zhao, Aaban Asfar Azmi, Avanti Gupte, Jenna Thibodeau, Shuang Liu, Jinli Yang, Guan Wang, Holly Edwards, Lisa A. Polin, Juiwanna Kushner, Sijana H. Dzinic, Kathryn White, Julie Boerner, Maik Hüttemann, Jay Yang, Yue Wang, Jeffrey W. Taub, Yubin Ge   +18 more
wiley   +1 more source

Using Performance Factors in Project Implementation: Comparing Agile, Hybrid Methodologies and Waterfall Approaches

Ученые записки Российской академии предпринимательства
This paper provides a comparative study of performance measurement ratios in various project management methodologies: Agile, hybrid approaches and Waterfall.The purpose of the study is to determine the role and significance of these coefficients in the ...
R. K. Nigmatullin, A. G. Dmitriev
doaj   +1 more source

About approaches to creation of all-Russian quality assurance agencies register

Высшее образование в России, 2022
RF-market of service on education quality assurance and independent accreditation of universities is only entering into a phase of active development. Regulation of this market is an integral requirement of its prosperity.
Yuriy B. Rubin, Alexandr A. Kovalenko, Tatiana A. Semkina, Erika Yu. Soboleva   +3 more
doaj  

Predictors of response and rational combinations for the novel MCL‐1 inhibitor MIK665 in acute myeloid leukemia

Molecular Oncology, EarlyView.
This study characterizes the responses of primary acute myeloid leukemia (AML) patient samples to the MCL‐1 inhibitor MIK665. The results revealed that monocytic differentiation is associated with MIK665 sensitivity. Conversely, elevated ABCB1 expression is a potential biomarker of resistance to the treatment, which can be overcome by the combination ...
Joseph Saad, Rhiannon Newman, Elmira Khabusheva, Sofia Aakko, Eric Durand, Mahesh Tambe, Heikki Kuusanmäki, Alun Parsons, Juho J. Miettinen, Komal Kumar Javarappa, Ezgi June Olgac, Nemo Ikonen, Mika Kontro, Kimmo Porkka, Heiko Maacke, Janghee Woo, Ensar Halilovic, Caroline A. Heckman   +17 more
wiley   +1 more source

Glycosylated LGALS3BP is highly secreted by bladder cancer cells and represents a novel urinary disease biomarker

Molecular Oncology, EarlyView.
Urinary LGALS3BP is elevated in bladder cancer patients compared to healthy controls as detected by the 1959 antibody–based ELISA. The antibody shows enhanced reactivity to the high‐mannose glycosylated variant secreted by cancer cells treated with kifunensine (KIF).
Asia Pece, Giulio Lovato, Ilaria Cela, Arianna Mercatelli, Benedetta Ferro, Jussi Nikkola, Sara Pagotto, Tommaso Grottola, Vincenzo De Laurenzi, Rossella Cicchetti, Antonio Marchetti, Luigi Schips, Rossano Lattanzio, Stefano Iacobelli, Emily Capone, Peter Black, Mads Daugaard, Michele Marchioni, Gianluca Sala   +18 more
wiley   +1 more source