Results 61 to 70 of about 778,777 (287)
FEBS Letters, EarlyView.This study reveals a unique active site enriched in methionine residues and demonstrates that these residues play a critical role by stabilizing carbocation intermediates through novel sulfur–cation interactions. Structure‐guided mutagenesis further revealed variants with significantly altered product profiles, enhancing pseudopterosin formation. These
Marion Ringel +13 more
wiley +1 more source
Friction Testing of a New Ligature [PDF]
, 2011 Objective: To determine if American Orthodontics\u27 (AO) new, experimental ligature demonstrates less friction in vitro when compared to four other ligatures on the market.
Mantel, Alison
core +1 more source
Hyperosmotic stress induces PARP1‐mediated HPF1‐dependent mono(ADP‐ribosyl)ation
FEBS Letters, EarlyView.Sorbitol‐induced hyperosmotic stress rapidly induces reversible mono(ADP‐ribosyl)ation (MARylation) on PARP1 without the signs of genotoxic signaling. We show that PARP1 autoMARylation is HPF1 dependent and forms hydroxylamine‐resistant O‐glycosidic linkages.
Anna Georgina Kopasz +11 more
wiley +1 more source
Analysis of factors influencing the use of agile methodologies in IT project management
Ученые записки Российской академии предпринимательстваIn the context of high uncertainty and rapid change in the field of information technology, the effective application of agile project management methodologies is becoming increasingly relevant.
G. Y. Postnikov, A. G. Dmitriev
doaj +1 more source
Anytime coalition structure generation on synergy graphs [PDF]
, 2014 We consider the coalition structure generation (CSG) problem on synergy graphs, which arises in many practical applications where communication constraints, social or trust relationships must be taken into account when forming coalitions.
Bistaffa, Filippo +4 more
core
Dual targeting of RET and SRC synergizes in RET fusion‐positive cancer cells
Molecular Oncology, EarlyView.Despite the strong activity of selective RET tyrosine kinase inhibitors (TKIs), resistance of RET fusion‐positive (RET+) lung cancer and thyroid cancer frequently occurs and is mainly driven by RET‐independent bypass mechanisms. Son et al. show that SRC TKIs significantly inhibit PAK and AKT survival signaling and enhance the efficacy of RET TKIs in ...
Juhyeon Son +13 more
wiley +1 more source
Ученые записки Российской академии предпринимательстваThis paper provides a comparative study of performance measurement ratios in various project management methodologies: Agile, hybrid approaches and Waterfall.The purpose of the study is to determine the role and significance of these coefficients in the ...
R. K. Nigmatullin, A. G. Dmitriev
doaj +1 more source
Potential therapeutic targeting of BKCa channels in glioblastoma treatment
Molecular Oncology, EarlyView.This review summarizes current insights into the role of BKCa and mitoBKCa channels in glioblastoma biology, their potential classification as oncochannels, and the emerging pharmacological strategies targeting these channels, emphasizing the translational challenges in developing BKCa‐directed therapies for glioblastoma treatment.
Kamila Maliszewska‐Olejniczak +4 more
wiley +1 more source
Regions, Innovation Systems, and the North-South Divide in Italy [PDF]
, 2018 Using firm-level data collected by Statistics Italy for 2008, 2011, and 2015, we examine the Triple-Helix synergy among geographical and size distributions of firms, and the NACE codes attributed to these firms, at the different levels of regional and ...
Cucco, Ivan, Leydesdorff, Loet
core +2 more sources
Cell surface interactome analysis identifies TSPAN4 as a negative regulator of PD‐L1 in melanoma
Molecular Oncology, EarlyView.Using cell surface proximity biotinylation, we identified tetraspanin TSPAN4 within the PD‐L1 interactome of melanoma cells. TSPAN4 negatively regulates PD‐L1 expression and lateral mobility by limiting its interaction with CMTM6 and promoting PD‐L1 degradation.
Guus A. Franken +7 more
wiley +1 more source