Results 71 to 80 of about 778,777 (287)

Prospects and Risks of Using ai Technology in Corporate Management

Вестник Российского экономического университета имени Г. В. Плеханова
The article analyzes the use of AI technologies in different spheres of human activities with special focus on their use in the field of corporate management.
A. V. Frolikov, A. E. Trubin, A. N. Aleksahin, A. M. Nechaev   +3 more
doaj   +1 more source

PARP inhibition and pharmacological ascorbate demonstrate synergy in castration‐resistant prostate cancer

Molecular Oncology, EarlyView.
Pharmacologic ascorbate (vitamin C) increases ROS, disrupts cellular metabolism, and induces DNA damage in CRPC cells. These effects sensitize tumors to PARP inhibition, producing synergistic growth suppression with olaparib in vitro and significantly delayed tumor progression in vivo. Pyruvate rescue confirms ROS‐dependent activity.
Nicolas Gordon, Peter T. Gallagher, Orly I. Richter, Neermala Poudel Neupane, Amy C. Mandigo, Jennifer J. McCann, Emanuela Dylgjeri, Irina Vasilevskaya, Christopher McNair, Channing J. Paller, Wm. Kevin Kelly, Karen E. Knudsen, Matthew J. Schiewer, Ayesha A. Shafi   +13 more
wiley   +1 more source

Adaptive strategic analysis models in a volatile market: case studies of today’s organizations

Путеводитель предпринимателя
Adaptive models of strategic analysis are crucial in unstable market conditions for modern organizations. These models assist organizations in identifying and responding to the changing business environment, ensuring their sustainable development and ...
A. E. Bogomaz, A. G. Dmitriev
doaj   +1 more source

Synergetic and redundant information flow detected by unnormalized Granger causality: application to resting state fMRI

, 2016
Objectives: We develop a framework for the analysis of synergy and redundancy in the pattern of information flow between subsystems of a complex network.
Angelini, Leonardo, Cortés, Jesus M., Faes, Luca, Marinazzo, Daniele, Stramaglia, Sebastiano, Wu, Guorong   +5 more
core   +1 more source

Therapeutic strategies for MMAE‐resistant bladder cancer through DPP4 inhibition

Molecular Oncology, EarlyView.
We established monomethyl auristatin E (MMAE)‐resistant bladder cancer (BC) cell lines by exposure to progressively increasing concentrations of MMAE in vitro. RNA sequencing showed DPP4 expression was increased in MMAE‐resistant BC cells. Both si‐DPP4 and the DPP4 inhibitor sitagliptin suppressed the viability of MMAE‐resistant BC cells.
Gang Li, Shuichi Tatarano, Hirofumi Yoshino, Saeki Saito, Mitsuhiko Tominaga, Junya Arima, Ikumi Fukuda, Takashi Sakaguchi, Ryosuke Matsushita, Yasutoshi Yamada, Hideki Enokida   +10 more
wiley   +1 more source

Recurrent cancer‐associated ERBB4 mutations are transforming and confer resistance to targeted therapies

Molecular Oncology, EarlyView.
We show that the majority of the 18 analyzed recurrent cancer‐associated ERBB4 mutations are transforming. The most potent mutations are activating, co‐operate with other ERBB receptors, and are sensitive to pan‐ERBB inhibitors. Activating ERBB4 mutations also promote therapy resistance in EGFR‐mutant lung cancer.
Veera K. Ojala, Sini Ahonen, Sara Peltola, Aura Tuohisto‐Kokko, Olaya Esparta, Peppi Suominen, Anne Jokilammi, Iman Farahani, Deepankar Chakroborty, Nikol Dibus, Steffen Boettcher, Tomi T. Airenne, Mark S. Johnson, Lisa D. Eli, Klaus Elenius, Kari J. Kurppa   +15 more
wiley   +1 more source

The use of a workbook as an efficient didactic means of teaching Russian in secondary vocational education organizations

Вестник Северо-Кавказского федерального университета
Introduction. Modern Russian society needs highly qualified, erudite professionals for sustainable development. The Russian language is considered to be the basis of professional, cultural, business and public communication.
L. M. Gareeva, A. V. Malkina, T. V. Mandzhieva   +2 more
doaj   +1 more source

Exploiting synergy between ontologies and recommender systems [PDF]

, 2002
Recommender systems learn about user preferences over time, automatically finding things of similar interest. This reduces the burden of creating explicit queries.
Alani, Harith, Middleton, Stuart E., Roure, David C. De, Shadbolt, Nigel R.   +3 more
core   +2 more sources

Dammarenediol II enhances etoposide‐induced apoptosis by targeting O‐GlcNAc transferase and Akt/GSK3β/mTOR signaling in liver cancer

Molecular Oncology, EarlyView.
Etoposide induces DNA damage, activating p53‐dependent apoptosis via caspase‐3/7, which cleaves PARP1. Dammarenediol II enhances this apoptotic pathway by suppressing O‐GlcNAc transferase activity, further decreasing O‐GlcNAcylation. The reduction in O‐GlcNAc levels boosts p53‐driven apoptosis and influences the Akt/GSK3β/mTOR signaling pathway ...
Jaehoon Lee, Byung‐Cheol Han, Gi‐Bang Koo, Jihye Park, Mijin Kwon, Young Bin Park, Jae‐Mun Choi, Seung‐Ho Lee, Sangho Roh   +8 more
wiley   +1 more source

Brand ambassadorship as an effective brand value management strategy: evolution and trends

Вестник университета
The ambassadorship phenomenon as a marketing strategy aimed at brand value management has been studied. The purpose of the study is to analyze ambassadorship as an effective strategy for brand value management.
T. V. Suvorova, M. V. Filiptsov
doaj   +1 more source