Results 81 to 90 of about 778,777 (287)

Basroparib inhibits YAP‐driven cancers by stabilizing angiomotin

Molecular Oncology, EarlyView.
Basroparib, a selective tankyrase inhibitor, suppresses Wnt signaling and attenuates YAP‐driven oncogenic programs by stabilizing angiomotin. It promotes AMOT–YAP complex formation, enforces cytoplasmic YAP sequestration, inhibits YAP/TEAD transcription, and sensitizes YAP‐active cancers, including KRAS‐mutant colorectal cancer, to MEK inhibition.
Young‐Ju Kwon, Dong Young Kim, Yuna Kim, Uk‐Il Kim, Jae‐Sung Kim   +4 more
wiley   +1 more source

Dimethyl fumarate combined with cisplatin at subcytotoxic doses sensitizes cervical cancer toward ferroptosis and apoptosis through GSH restriction and p53 (re)activation

Molecular Oncology, EarlyView.
Dimethyl fumarate (DMF) reduces growth of HPV‐positive cervical cancer spheroids and induces ferroptosis in cervical cancer cells via blocking SLC7A11/Glutathione (GSH) axis. Combination of subcytotoxic doses of DMF and cisplatin (CDDP) further suppresses spheroid growth and drives cell death in 2D culture models.
Carolina Punziano, Giuseppina Minopoli, Simona Romano, Laura Marrone, Katia Aquilano, Maria Lina Tornesello, Raffaella Faraonio   +6 more
wiley   +1 more source

Targeted modulation of IGFL2‐AS1 reveals its translational potential in cervical adenocarcinoma

Molecular Oncology, EarlyView.
Cervical adenocarcinoma patients face worse outcomes than squamous cell carcinoma counterparts despite similar treatment. The identification of IGFL2‐AS1's differential expression provides a molecular basis for distinguishing these histotypes, paving the way for personalized therapies and improved survival in vulnerable populations globally.
Ricardo Cesar Cintra, Lucca Paolo Hsu Helmich, Daniel Rodrigues de Bastos, Laura Sichero, Patrícia Savio de Araujo‐Souza, Fabio Passetti, Luisa Lina Villa   +6 more
wiley   +1 more source

Specific Introduction of Hrm-System in Trade Organizations

Вестник Российского экономического университета имени Г. В. Плеханова
A key topic in discussing the development of social and economic systems and state policy has been overall digital transformation. The introduction of digital technologies is a principle line in strategy of the majority of organizations, including trade ...
N. P. Tishkina, R. V. Kamanina, L. I. Gratsianova   +2 more
doaj   +1 more source

IMPDH inhibition enhances cytarabine efficacy in SAMHD1‐expressing leukaemia cells via guanine nucleotide depletion

Molecular Oncology, EarlyView.
Cytarabine is a key therapy for acute myeloid leukaemia (AML), but its efficacy is limited by the dNTPase SAMHD1, which hydrolyses its active metabolite. Screening nucleotide biosynthesis inhibitors revealed that IMPDH inhibitors selectively sensitise SAMHD1‐proficient AML cells to cytarabine.
Miriam Yagüe‐Capilla, Christopher Dirks, Caroline Eiden, Sonja K. Fesenmayer, Femke M. Hormann, Yolande Klootsema, Ingrid Lilienthal, Si Min Zhang, Nikolas Herold, Sean G. Rudd   +9 more
wiley   +1 more source

Challenges and Prospects of Crypto-Currency Market Development

Вестник Российского экономического университета имени Г. В. Плеханова
The article deals with the research on global crypto-currency market and analysis of its development trends. Special attention was paid to national regulation of crypto-currency and activity connected with it, which is topical today due to introduction ...
O. P. Kultygin, N. N. Lyublinskaya, E. N. Tokmakova, A. E. Trubin   +3 more
doaj   +1 more source

Customer value creation in financial services [PDF]

, 2001
Customer value creation is allegedly at the centre of relationships between service recipients and service providers (such as financial service organisations in general, and commercial banks in particular).
Bátiz-Lazo, Bernardo
core  

Dual PI3K/AKT and CDK4/6 inhibition reveals selective sensitivity in an SHH medulloblastoma stem cell model

Molecular Oncology, EarlyView.
Targeted therapy was evaluated in SHH medulloblastoma using neuroepithelial stem cell (NES) and tumor‐derived NES‐like (tNES) models in 2D monolayers and 3D spheroids. PI3K, AKT, and CDK4/6 inhibitors had minimal effects in NES but markedly reduced viability and growth and induced apoptosis in tNES cells, revealing distinct therapeutic vulnerabilities.
Monika Lukoseviciute, Madeleine Birgersson, Paolo Ceriani, Margareta Wilhelm, Ourania N Kostopoulou   +4 more
wiley   +1 more source

SCIENTIFIC AND PEDAGOGICAL WORKERS AND ADMINISTRATIVE STAFF: CONFLICT OF INTEREST OR CONSTRUCTIVE INTERACTION?

Высшее образование в России, 2017
The article discusses the effectiveness of the system of university internal management providing the interaction of two structural units of an educational institution - chairs and managerial staff.
Ashot R. Alaverdov, Natalia V. Gromova
doaj  

Analytic Approach to non-Newtonian Jeffery Fluid Flow in a Catheterized Curved Artery: Exploring the Impact of Heat, Mass Transfer and Magnetic Field

Communications in Advanced Mathematical Sciences
This investigation analyzes the physical properties of blood flow via a catheter in a damaged, curved artery while taking mass and heat transfer in a magnetic field.
Surendra Kumar Agarwal, Gauri Sethi
doaj   +1 more source