Synonymous substitution rates predict HIV disease progression as a result of underlying replication dynamics [PDF]
, 2007 Upon HIV transmission, some patients develop AIDS in only a few months, while others remain disease free for 20 or more years. This variation in the rate of disease progression is poorly understood and has been attributed to host genetics, host immune ...
Pybus, OG +37 more
core +1 more source
Evolutionary pressures on the yeast transcriptome [PDF]
, 2015 Codon usage bias (CUB) is the well known phenomenon that the frequency of synonymous codons is unequal. This is presumably the result of adaptive pressures favouring some codons over others.
Chu, Dominique, Salykin, Anton
core +1 more source
Variation in the strength of selected codon usage bias among bacteria [PDF]
, 2005 Among bacteria, many species have synonymous codon usage patterns that have been influenced by natural selection for those codons that are translated more accurately and/or efficiently. However, in other species selection appears to have been ineffective.
Sharp, P M +5 more
core +1 more source
Solving the riddle of codon usage preferences: a test for translational selection [PDF]
, 2004 Translational selection is responsible for the unequal usage of synonymous codons in protein coding genes in a wide variety of organisms. It is one of the most subtle and pervasive forces of molecular evolution, yet, establishing the underlying causes ...
Savva, Renos +2 more
core +1 more source
A comparative study of adaptive mutation operators for metaheuristics [PDF]
, 2009 Genetic algorithms (GAs) are a class of stochastic optimization methods inspired by the principles of natural evolution. Adaptation of strategy parameters and genetic operators has become an important and promising research area in GAs.
Yang, S, Li, C, Korejo, I
core +6 more sources
A rare co-segregation-mutation in the insulin receptor substrate 1 gene in one Chinese family with ankylosing spondylitis. [PDF]
PLoS ONE, 2015 Ankylosing spondylitis (AS; MIM 106300) is a common rheumatic disease with strong genetic components affecting approximately 0.3% of the population. The exact genetic mechanism of AS remains elusive. Our previous study showed that AS could be transmitted
Ju Rong +14 more
doaj +1 more source
Synonymous mutations in von-Hippel Lindau gene cause familial pheochromocytoma [PDF]
Jichu yixue yu linchuang, 2020 Objective This is a case report of family with VHL disease caused by a rare synonymous mutation of VHL gene and then the frequency of the mutation in pheochromocytoma/paraganglioma (PPGL) was investigated.
MA Xiao-sen, ZHANG Xue-bin, ZHOU Ting, CUI Yun-ying, TONG An-li
doaj
Evidence of selection upon genomic GC-content in bacteria. [PDF]
PLoS Genetics, 2010 The genomic GC-content of bacteria varies dramatically, from less than 20% to more than 70%. This variation is generally ascribed to differences in the pattern of mutation between bacteria. Here we test this hypothesis by examining patterns of synonymous
Falk Hildebrand +2 more
doaj +1 more source
Biological Roles of Protein-Coding Tandem Repeats in the Yeast Candida Albicans
Journal of Fungi, 2018 Tandem repeat (TR) DNA mutates faster than other DNA by insertion and deletion of repeats. Large parts of eukaryotic proteomes are encoded by ORFs containing protein-coding TRs (TR-ORFs, pcTRs) with largely unknown biological consequences.
Matt Wilkins, Ningxin Zhang, Jan Schmid
doaj +1 more source
Exome sequencing in 53 sporadic cases of schizophrenia identifies 18 putative candidate genes. [PDF]
PLoS ONE, 2014 Schizophrenia (SCZ) is a severe, debilitating mental illness which has a significant genetic component. The identification of genetic factors related to SCZ has been challenging and these factors remain largely unknown. To evaluate the contribution of de
Michel Guipponi +20 more
doaj +1 more source