Molecular Mechanisms and the Significance of Synonymous Mutations [PDF]
BiomoleculesSynonymous mutations result from the degeneracy of the genetic code. Most amino acids are encoded by two or more codons, and mutations that change a codon to another synonymous codon do not change the amino acid in the gene product.
Peter Oelschlaeger
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Incorporating mutational heterogeneity to identify genes that are enriched for synonymous mutations in cancer [PDF]
BMC Bioinformatics, 2023 Background Synonymous mutations, which change the DNA sequence but not the encoded protein sequence, can affect protein structure and function, mRNA maturation, and mRNA half-lives.
Yiyun Rao +3 more
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PredDSMC: A predictor for driver synonymous mutations in human cancers [PDF]
Frontiers in Genetics, 2023 Introduction: Driver mutations play a critical role in the occurrence and development of human cancers. Most studies have focused on missense mutations that function as drivers in cancer.
Lihua Wang +4 more
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Context-dependent and -independent selection on synonymous mutations revealed by 1,135 genomes of Arabidopsis thaliana [PDF]
BMC Ecology and Evolution, 2021 Background Synonymous mutations do not alter the amino acids and therefore are regarded as neutral for a long time. However, they do change the tRNA adaptation index (tAI) of a particular codon (independent of its context), affecting the tRNA ...
Duan Chu, Lai Wei
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Structural impact of synonymous mutations in six SARS-CoV-2 Variants of Concern. [PDF]
PLoS ONESARS-CoV-2 continues to spread and infect people worldwide. While most effort into characterizing variants of this virus have focused on non-synonymous changes, accumulation of synonymous mutations in different viral variants has also occurred.
Alison Ziesel, Hosna Jabbari
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Synonymous mutations that regulate translation speed might play a non-negligible role in liver cancer development [PDF]
BMC Cancer, 2021 Background Synonymous mutations do not change the protein sequences. Automatically, they have been regarded as neutral events and are ignored in the mutation-based cancer studies.
Qun Li +5 more
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Somatic synonymous mutations in regulatory elements contribute to the genetic aetiology of melanoma [PDF]
BMC Medical Genomics, 2020 Background Non-synonymous mutations altering tumor suppressor genes and oncogenes are widely studied. However, synonymous mutations, which do not alter the protein sequence, are rarely investigated in melanoma genome studies. Methods We explored the role
Di Zhang, Junfeng Xia
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The impact of non-synonymous mutations on miRNA binding sites within the SARS-CoV-2 NSP3 and NSP4 genes [PDF]
Scientific Reports, 2023 Non-synonymous mutations in the SARS-CoV-2 spike region affect cell entry, tropism, and immune evasion, while frequent synonymous mutations may modify viral fitness.
S. M. Ali Hosseini Rad +3 more
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Fitness difference between two synonymous mutations of Phytophthora infestans ATP6 gene [PDF]
BMC Ecology and EvolutionBackground Sequence variation produced by mutation provides the ultimate source of natural selection for species adaptation. Unlike nonsynonymous mutation, synonymous mutations are generally considered to be selectively neutral but accumulating evidence ...
Oswald Nkurikiyimfura +8 more
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Genome-wide analysis on the maize genome reveals weak selection on synonymous mutations [PDF]
BMC Genomics, 2020 Background Synonymous mutations are able to change the tAI (tRNA adaptation index) of a codon and consequently affect the local translation rate. Intuitively, one may hypothesize that those synonymous mutations which increase the tAI values are favored ...
Duan Chu, Lai Wei
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