Results 1 to 10 of about 2,021 (209)
A pan-cancer analysis of synonymous mutations [PDF]
Nature Communications, 2019 Synonymous mutations do not alter amino acid sequence but may exert oncogenic effects in other ways. Here, the authors present a catalogue of synonymous mutations in cancer and characterise their properties.
Yogita Sharma +7 more
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An analysis of mutational signatures of synonymous mutations across 15 cancer types [PDF]
BMC Medical Genetics, 2019 Background Synonymous mutations have been identified to play important roles in cancer development, although they do not modify the protein sequences.
Yannan Bin +4 more
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Compensating the Fitness Costs of Synonymous Mutations [PDF]
Molecular Biology and Evolution, 2016 Synonymous mutations do not change the sequence of the polypeptide but they may still influence fitness. We investigated in Salmonella enterica how four synonymous mutations in the rpsT gene (encoding ribosomal protein S20) reduce fitness (i.e., growth rate) and the mechanisms by which this cost can be genetically compensated.
Dan Andersson +2 more
exaly +4 more sources
BMC Bioinformatics, 2023 Background Synonymous mutations, which change the DNA sequence but not the encoded protein sequence, can affect protein structure and function, mRNA maturation, and mRNA half-lives.
Yiyun Rao +3 more
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PredDSMC: A predictor for driver synonymous mutations in human cancers
Frontiers in Genetics, 2023 Introduction: Driver mutations play a critical role in the occurrence and development of human cancers. Most studies have focused on missense mutations that function as drivers in cancer.
Lihua Wang +4 more
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Molecular Mechanisms and the Significance of Synonymous Mutations
BiomoleculesSynonymous mutations result from the degeneracy of the genetic code. Most amino acids are encoded by two or more codons, and mutations that change a codon to another synonymous codon do not change the amino acid in the gene product.
Peter Oelschlaeger
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Synonymous Mutations Frequently Act as Driver Mutations in Human Cancers [PDF]
Cell, 2014 Synonymous mutations change the sequence of a gene without directly altering the sequence of the encoded protein. Here, we present evidence that these "silent" mutations frequently contribute to human cancer. Selection on synonymous mutations in oncogenes is cancer-type specific, and although the functional consequences of cancer-associated synonymous ...
Valcarcel J, Fran Supek, Ben Lehner
exaly +4 more sources
The impact of non-neutral synonymous mutations when inferring selection on nonsynonymous mutations
GeneticsAbstract The distribution of fitness effects (DFE) describes the proportions of new mutations that have different effects on reproductive fitness. Accurate measurements of the DFE are important because the DFE is a fundamental parameter in evolutionary genetics and has implications for our understanding of other phenomena like complex ...
Kirk Lohmueller +2 more
exaly +5 more sources
Mutation rates and selection on synonymous mutations in SARS-CoV-2 [PDF]
Genome Biology and Evolution, 2021 A bstract The COVID-19 pandemic has seen an unprecedented response from the sequencing community. Leveraging the sequence data from more than 140,000 SARS-CoV-2 genomes, we study mutation rates and selective pressures affecting the virus.
Nicola De Maio +5 more
openaire +4 more sources
BMC Ecology and Evolution, 2021 Background Synonymous mutations do not alter the amino acids and therefore are regarded as neutral for a long time. However, they do change the tRNA adaptation index (tAI) of a particular codon (independent of its context), affecting the tRNA ...
Duan Chu, Lai Wei
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