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Frontiers in Genetics, 2021 Synonymous mutations are generally considered non-pathogenic because it did not alter the amino acids of the encoded protein. Publications of the associations between synonymous mutations and abnormal splicing have increased recently, however, not much ...
Pengzhen Jin +12 more
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BMC Genomics, 2023 Background Single synonymous codon mutations typically have only minor or no effects on gene function. Here, we estimate the effects on cell growth of ~ 200 single synonymous codon mutations in an operonic context by mutating almost all positions of ccdB,
Priyanka Bajaj +2 more
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Modelling the effects of single point mutations on the structure and function of proteins [PDF]
, 2009 Insight into the molecular impact of mutations on the structure and function of proteins is of great importance in biology. It helps understand the evolution of proteins, rationalize the molecular causes of disease and, from a practical perspective, aid ...
Battey, James Nicolas Duncan
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Genetic variability in L1 and L2 genes of HPV-16 and HPV-58 in Southwest China. [PDF]
PLoS ONE, 2013 HPV account for most of the incidence of cervical cancer. Approximately 90% of anal cancers and a smaller subset (
Yaofei Yue +11 more
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Molecular Plant-Microbe Interactions, 2004 Deletion or alteration of an avirulence gene are two mechanisms that allow pathogens to escape recognition mediated by the corresponding resistance gene in the host. We studied these two mechanisms for the NIP1 avirulence gene in field populations of the
Stéphanie Schürch +4 more
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The distribution of fitness effects among synonymous mutations in a gene under directional selection
eLife, 2019 The fitness effects of synonymous mutations, nucleotide changes that do not alter the encoded amino acid, have often been assumed to be neutral, but a growing body of evidence suggests otherwise.
Eleonore Lebeuf-Taylor +4 more
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Synonymous mutations make dramatic contributions to fitness when growth is limited by a weak-link enzyme. [PDF]
PLoS Genetics, 2018 Synonymous mutations do not alter the specified amino acid but may alter the structure or function of an mRNA in ways that impact fitness. There are few examples in the literature, however, in which the effects of synonymous mutations on microbial growth
JohnCarlo Kristofich +7 more
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Sequences generation with only synonymous mutations
, 2022 Starting from a given ORF (Amno acid sequence in .fas), this script introduces a single nucleotide synonymous mutation randomly in each triplet of the coding sequence. This process is repeated N times.
LAFFORGUE Guillaume
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An analysis of mutational signatures of synonymous mutations across 15 cancer types
BMC Medical Genetics, 2019 Background Synonymous mutations have been identified to play important roles in cancer development, although they do not modify the protein sequences.
Yannan Bin +4 more
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