The Fitness Effects of Synonymous Mutations in DNA and RNA Viruses [PDF]
Molecular Biology and Evolution, 2011 Despite being silent with respect to protein sequence, synonymous nucleotide substitutions can be targeted by natural selection directly at the DNA or RNA level. However, there has been no systematic assessment of how frequent this type of selection is.
Cuevas, José M. +2 more
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Synonymous mutations make dramatic contributions to fitness when growth is limited by a weak-link enzyme. [PDF]
PLoS Genetics, 2018 Synonymous mutations do not alter the specified amino acid but may alter the structure or function of an mRNA in ways that impact fitness. There are few examples in the literature, however, in which the effects of synonymous mutations on microbial growth
JohnCarlo Kristofich +7 more
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Genome-wide analysis on the maize genome reveals weak selection on synonymous mutations
BMC Genomics, 2020 Background Synonymous mutations are able to change the tAI (tRNA adaptation index) of a codon and consequently affect the local translation rate. Intuitively, one may hypothesize that those synonymous mutations which increase the tAI values are favored ...
Duan Chu, Lai Wei
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Within-patient mutation frequencies reveal fitness costs of CpG dinucleotides and drastic amino acid changes in HIV. [PDF]
PLoS Genetics, 2018 HIV has a high mutation rate, which contributes to its ability to evolve quickly. However, we know little about the fitness costs of individual HIV mutations in vivo, their distribution and the different factors shaping the viral fitness landscape.
Kristof Theys +5 more
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Impact of Synonymous Genome Recoding on the HIV Life Cycle
Frontiers in Microbiology, 2021 Synonymous mutations within protein coding regions introduce changes in DNA or messenger (m) RNA, without mutating the encoded proteins. Synonymous recoding of virus genomes has facilitated the identification of previously unknown virus biological ...
Ana Jordan-Paiz +2 more
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E6 and E7 Gene Polymorphisms in Human Papillomavirus Types-58 and 33 Identified in Southwest China.
PLoS ONE, 2017 Cancer of the cervix is associated with infection by certain types of human papillomavirus (HPV). The gene variants differ in immune responses and oncogenic potential.
Zuyi Chen +7 more
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PLoS ONE, 2021 Dipeptidyl peptidase 4 (DPP4) has been identified as the main receptor of MERS-CoV facilitating its cellular entry and enhancing its viral replication upon the emergence of this novel coronavirus. DPP4 receptor is highly conserved among many species, but
Anass Abbad +4 more
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The evolutionary impacts of synonymous mutations
, 2021 During the 50 years since the genetic code was cracked, our understanding of the evolutionary consequences of synonymous mutations has undergone a dramatic shift. Synonymous codon changes were initially considered selectively neutral, and as such, exemplars of evolution via genetic drift.
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The importance of
Haemophilia, 2016 IntroductionMutational analysis is commonly used to support the diagnosis and management of haemophilia. This has allowed for the generation of large mutation databases which provide unparalleled insight into genotype–phenotype relationships. Haemophilia is associated with inversions, deletions, insertions, nonsense and missense mutations.
N, Hamasaki-Katagiri +8 more
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Mutations primarily alter the inclusion of alternatively spliced exons
eLife, 2020 Genetic analyses and systematic mutagenesis have revealed that synonymous, non-synonymous and intronic mutations frequently alter the inclusion levels of alternatively spliced exons, consistent with the concept that altered splicing might be a common ...
Pablo Baeza-Centurion +3 more
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