Within-patient mutation frequencies reveal fitness costs of CpG dinucleotides and drastic amino acid changes in HIV. [PDF]
PLoS Genetics, 2018 HIV has a high mutation rate, which contributes to its ability to evolve quickly. However, we know little about the fitness costs of individual HIV mutations in vivo, their distribution and the different factors shaping the viral fitness landscape.
Kristof Theys +5 more
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Impact of Synonymous Genome Recoding on the HIV Life Cycle
Frontiers in Microbiology, 2021 Synonymous mutations within protein coding regions introduce changes in DNA or messenger (m) RNA, without mutating the encoded proteins. Synonymous recoding of virus genomes has facilitated the identification of previously unknown virus biological ...
Ana Jordan-Paiz +2 more
doaj +1 more source
E6 and E7 Gene Polymorphisms in Human Papillomavirus Types-58 and 33 Identified in Southwest China.
PLoS ONE, 2017 Cancer of the cervix is associated with infection by certain types of human papillomavirus (HPV). The gene variants differ in immune responses and oncogenic potential.
Zuyi Chen +7 more
doaj +1 more source
Bayesian Estimation of Nonsynonymous/Synonymous Rate Ratios for Pairwise Sequence Comparisons [PDF]
, 2014 The nonsynonymous/synonymous rate ratio (ω = dN/dS) is an important measure of the mode and strength of natural selection acting on nonsynonymous mutations in protein-coding genes. The simplest such analysis is the estimation of the dN/dS ratio using two
dos Reis, M, Yang, Z, Angelis, K
core +1 more source
Fitness and Epistatic Effects of Synonymous Mutations in Yeast
, 2023 Synonymous mutations have long been considered neutral, but there is accumulating evidence that they influence many biological processes, ranging from transcription to translation, except that they do not alter amino acid sequences.
Shen, Xukang
core +1 more source
Data from: Unraveling the causes of adaptive benefits of synonymous mutations in TEM-1 β-lactamase [PDF]
, 2018 While synonymous mutations were long thought to be without phenotypic consequences, there is growing evidence they can affect gene expression, protein folding and ultimately the fitness of an organism.
Schenk, M.F. +9 more
core +4 more sources
PLoS ONE, 2021 Dipeptidyl peptidase 4 (DPP4) has been identified as the main receptor of MERS-CoV facilitating its cellular entry and enhancing its viral replication upon the emergence of this novel coronavirus. DPP4 receptor is highly conserved among many species, but
Anass Abbad +4 more
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Presentation1_PredDSMC: A predictor for driver synonymous mutations in human cancers.pdf
, 2023 Introduction: Driver mutations play a critical role in the occurrence and development of human cancers. Most studies have focused on missense mutations that function as drivers in cancer.
Lihua Wang (14548) +4 more
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Mutations primarily alter the inclusion of alternatively spliced exons
eLife, 2020 Genetic analyses and systematic mutagenesis have revealed that synonymous, non-synonymous and intronic mutations frequently alter the inclusion levels of alternatively spliced exons, consistent with the concept that altered splicing might be a common ...
Pablo Baeza-Centurion +3 more
doaj +1 more source
Four synonymous mutations and two non-synonymous mutations in EPAS1.
, 2017 Four synonymous mutations and two non-synonymous mutations in EPAS1.
Qing Zhu (349093) +7 more
core +1 more source