Results 11 to 20 of about 771,131 (233)

A pan-cancer analysis of synonymous mutations [PDF]

Nature Communications, 2019
Synonymous mutations do not alter amino acid sequence but may exert oncogenic effects in other ways. Here, the authors present a catalogue of synonymous mutations in cancer and characterise their properties.
Yogita Sharma, Milad Miladi, Sandeep Dukare, Karine Boulay, Maiwen Caudron-Herger, Matthias Groß, Rolf Backofen, Sven Diederichs   +7 more
doaj   +2 more sources

Synonymous mutations in representative yeast genes are mostly strongly non-neutral [PDF]

Nature, 2022
Jianzhi Zhang, Siliang Song, Xukang Shen
exaly   +2 more sources

Effects of Synonymous Mutations beyond Codon Bias: The Evidence for Adaptive Synonymous Substitutions from Microbial Evolution Experiments. [PDF]

Genome Biology and Evolution, 2021
Stephanie Bedhomme, Susan F Bailey, Luz Angela Alonso Morales   +2 more
exaly   +2 more sources

A multispecies approach for comparing sequence evolution of X-linked and autosomal sites in Drosophila [PDF]

, 2008
Population genetics models show that, under certain conditions, the X chromosome is expected to be under more efficient selection than the autosomes.
Vicoso, Beatriz, Haddrill, Penelope R, Charlesworth, Brian, Haddrill, Penelope R.   +3 more
core   +4 more sources

Functional synonymous mutations and their evolutionary consequences [PDF]

Nature Reviews Genetics
Jianzhi Zhang, Wenfeng Qian
exaly   +2 more sources

Fitness costs of synonymous mutations in the rpsT gene can be compensated by restoring mRNA base pairing. [PDF]

PLoS ONE, 2013
We previously reported that the distribution of fitness effects for non-synonymous and synonymous mutations in Salmonella typhimurium ribosomal proteins S20 and L1 are similar, suggesting that fitness constraints are present at the level of mRNA. Here we
Peter A Lind, Dan I Andersson
doaj   +1 more source

Synonymous mutations.

, 2021
The synonymous mutations detected in the study. (XLSX)
Lilja Jansson (9620924), Miko Valori (5865947), Pentti J. Tienari (9620939)   +2 more
core   +1 more source

SARS-CoV2 envelope protein: non-synonymous mutations and its consequences [PDF]

Genomics, 2020
Pabitra Pal Choudhury, Bidyut Roy, Sk Sarif Hassan   +2 more
exaly   +2 more sources

Germline mutations in the oncogene EZH2 cause Weaver syndrome and increased human height. [PDF]

, 2011
The biological processes controlling human growth are diverse, complex and poorly understood. Genetic factors are important and human height has been shown to be a highly polygenic trait to which common and rare genetic variation contributes.
Cole, Trevor, Tatton-Brown, Katrina, Douglas, Jenny, Sheila Seal, Loveday, C, Patton, Michael, A Splitt, Ruark, E, Patricia Wheeler, Ra Hanks, Michael Patton, Murray, A, Katie Snape, Ramsay, Emma, Seal, Sheila, Clare Taylor, Ramsay, E, Volker Strenger, Taylor, C, Vivienne Mcconnell, Zachariou, A, Temple, KI, Loveday, Chey, Tatton-Brown, K, Patton, M, Temple, IK, Katrina Tatton-brown, Duarte, SDELV, Seal, S, Douglas, J, Jenny Douglas, Raith, W, Clericuzio, Carol, Temple, I. Karen, Magee, A, Anne Murray, Flinter, F, ?, ?, Splitt, Miranda, Banka, S, Rahman, N, Strenger, V, Flinter, Frances, Trevor Cole, Rankin, Julia, Carol Clericuzio, Snape, Katie, Zachariou, Anna, Temple, Karen I, Anna Zachariou, Murray, Anne, Splitt, M, Julia Rankin, Temple, Karen I., Nazneen Rahman, Elise Ruark, Wheeler, P, Magee, Alex, Childhood Overgrowth Collaboration, The Childhood Overgrowth, Strenger, Volker, Duarte, SDV, I Karen Temple, McConnell, Vivienne, Perdeaux, Elizabeth R, Banka, Siddharth, Clericuzio, C, Hanks, Sandra, Siddharth Banka, Del Vecchio Duarte, Frances Flinter, Wheeler, Patricia, Emma Ramsay, Ruark, Elise, Banka, Siddharth; id_orcid, McConnell, V, Elizabeth R, Perdeaux, ER, Cole, T, Taylor, Clare, Snape, K, Raith, Wolfgang, Chey Loveday, Rahman, Nazneen, Duarte, Silvana Del Vecchio, Hanks, S, Perdeaux, Elizabeth R., Alex Magee, Rankin, J   +88 more
core   +2 more sources

Reduced efficacy of selection in regions of the Drosophila genome that lack crossing over [PDF]

, 2007
The recombinational environment is predicted to influence patterns of protein sequence evolution through the effects of Hill-Robertson interference among linked sites subject to selection.
Haddrill, Penelope R, Tomaras, Dimitris, Charlesworth, Brian, Halligan, Daniel L   +3 more
core   +4 more sources