Results 81 to 90 of about 70,874 (312)
Advanced Science, EarlyView.A novel epitranscriptomic mechanism in rheumatoid arthritis is uncovered: NSUN2 promotes disease via m5C‐dependent stabilization of ICMT mRNA, fueling the migration and invasion of pathogenic RA FLS. Targeting this axis with engineered nanoparticles (Ce/SAA NPs) effectively inhibits disease progression, presenting a precise therapeutic strategy ...
Ruiru Li +15 more
wiley +1 more source
RELATION BETWEEN SYNOVIAL JOINT AND FIBRINOLYTIC ACTIVITY OF SYNOVIAL FLUID [PDF]
, 1966 In rheumatoid arthritis and osteoarthritis it is observed that the streptokinase-added fibrinolytic activity of the synovial fluid is higher than the normal value and the inhibitor is increased.
Takakazu ARAI +4 more
core +1 more source
Advanced Science, EarlyView.We have shown that both simulated and actual spaceflight contribute to cartilage degradation in the knees of mice. Using RNA sequencing and bioenergetic profiling, we identified NADPH oxidase 4 (NOX4) as a key factor driving these changes. Additionally, we found that kaempferol, a naturally occurring flavonoid that binds directly to NOX4, reduces ...
Yuesong Yin +23 more
wiley +1 more source
The Turkish Journal of Gastroenterology, 2017 Objectives: This study aims (i) to compare synovial fluid and serum cartilage oligomeric matrix protein levels in patients with primary knee osteoarthritis and healthy controls, (ii) compare variations of synovial fluid and serum cartilage oligomeric ...
Ruben Daniel ARELLANO +5 more
doaj
Computational modelling of fluid load support in articular cartilage [PDF]
, 2013 Natural articular cartilage is known to be an excellent bearing material with very low friction coefficient and wear rate. Theoretical and experimental studies have demonstrated that the interstitial fluid of cartilage is pressurized considerably ...
An, Shuqiang
core
Advanced Science, EarlyView.In the pathological context of osteoarthritis (OA), the phosphorylation of AKT1 at Ser473 enhances its binding to Lys140 of Insig1, which facilitates the formation of AKT1–Insig1 complex. Subsequently, the activation of AKT1 promotes the phosphorylation of Insig1 at Ser189, potentially enhancing the dissociation of Insig1 from sterol regulatory element‑
Xiaoqi Zhang +19 more
wiley +1 more source
Determination of ratio of passing of flunixin meglumine into sinovial fluid [PDF]
Eurasian Journal of Veterinary SciencesThis experimental study was conducted to determine of ratio of passing of flunixin meglumine into synovial fluid. Five healthy dogs were usedas materials. Flunixin meglumine (FinadynR) was injected intramuscularly (1.1 mg/kg) to each dog.
Bünyamin Traş +2 more
doaj
Natural Aging of Biomaterials in Ambient and Physiological Environments
Advanced NanoBiomed Research, EarlyView.Biomaterials used in biomedical applications can change their physical properties over time, even under ambient and physiological conditions. This review highlights key studies on the natural aging of materials ranging from soft hydrogels to metals and ceramics, emphasizing how time‐dependent changes influence function and performance.
Shuyu Zhang, Anne E. Staples
wiley +1 more source
OA and RA affected synovial fluid. [PDF]
, 2018 OA and RA affected synovial fluid.
Lars Bräuer (287741) +14 more
core +1 more source
Liposomal Delivery of L‐2‐Hydroxyglutarate for Targeting Epigenetic Dysregulation in Osteoarthritis
Advanced NanoBiomed Research, EarlyView.Osteoarthritis involves cartilage degeneration, inflammation, and epigenetic dysregulation. A liposomal formulation of the TET1 inhibitor L‐2‐hydroxyglutarate to overcome rapid joint clearance was developed. The formulation showed good physicochemical properties, reduced inflammatory and catabolic gene expression in chondrocytes, and alleviated ...
Denise Murgia +10 more
wiley +1 more source