Results 71 to 80 of about 1,338,566 (303)

Serum and Synovial Fluid Interleukin-6 for the Diagnosis of Periprosthetic Joint Infection

Scientific Reports, 2017
A gold standard for diagnosis of periprosthetic joint infection (PJI) has not yet been established. The objective of this study was to evaluate the diagnostic value of serum and synovial fluid interleukin (IL)-6 levels for PJI.
Kai Xie, Kerong Dai, Xinhua Qu, Mengning Yan   +3 more
doaj   +1 more source

Human TMJ synovial fluid.

, 2019
Human TMJ synovial fluid.
Serhiy Pylawka (5556455), Mallory Morel (7490336), Angela Ruscitto (7490339), Mildred C. Embree (7490345), Gwendolyn Reeve (7490342)   +4 more
core   +1 more source

Multi‐Tissue Crosstalk Regulating Meniscus Healing Under Inflammation and Physiological Loading

Advanced Science, EarlyView.
Using a novel Meniscus‐on‐a‐chip (MoC) model integrated with a meniscus‐specific bioreactor, this study investigated the roles of multi‐tissue crosstalk that regulates injury, healing, and degeneration of the meniscus injury under inflammation and pathophysiological loading.
Hun Jin Jeong, Elen Zhu, Min Seo Kang, Ming Wang, Sam Comito, Chang H. Lee   +5 more
wiley   +1 more source

A Versatile DNA‐Encoded Library Platform for the Discovery of Highly Cooperative Chemical Inducers of Proximity

Advanced Science, EarlyView.
We present a versatile DNA‐encoded library (DEL) platform designed for rapid library synthesis and subsequent screening for chemical inducers of proximity (CIPs) across various presenter proteins of choice. Applying this approach, we discovered a novel molecular glue‐like compound mediating CRBN‐BRD9 ternary complex formation with remarkable ...
Bingqi Tong, Sunny A. Tang, Yifan Deng, Zhihan Nan, Alison X. Gao, Gregory A. Michaud, Simone Bonazzi, Frédéric Berst, Frédéric J. Zécri, Shuang Liu, William J. Gibson, Stuart L. Schreiber   +11 more
wiley   +1 more source

Diagnostic Potential of the Synovial Fluid

, 2018
Introduction: Biochemical changes accompanying intracapsular pathological processes represent potential source of information exploitable in diagnostics, differential diagnostics or monitoring of temporomandibular joint disorders.
M. Rabajdová, J. Kluknavská, V. Schwartzová, A. Birková   +3 more
core   +1 more source

Digoxin Alleviates Osteoarthritis by Inhibiting Macrophage Extracellular Trap Formation via Disruption of the LSP1‐SOD1 Interaction

Advanced Science, EarlyView.
Synovial macrophages in osteoarthritis upregulate LSP1, which directly binds and inhibits SOD1, triggering a redox imbalance that activates both NOX and mitochondrial ROS pathways. This cascade drives the release of macrophage extracellular traps (METs), causing chondrocyte damage and disease progression.
Yankai Pan, Xinzhe Feng, Chuanju Liu, Jianfei Tong, Zhi Li, Chenxu Liu, Yutong Dong, Chen Meng, Yihong Xu, Weidong Xu   +9 more
wiley   +1 more source

OA and RA affected synovial fluid.

, 2018
OA and RA affected synovial fluid.
Lars Bräuer (287741), Nadine Hartjen (5774528), Brigitte Müller-Hilke (3160920), Mary B. Goldring (234026), Thomas Müller (3554), Horst Claassen (830393), Michael Tsokos (5774534), Friedrich Paulsen (44377), Fabian Garreis (457616), Kolja Gelse (5774540), Beate Reiß (5774531), Stephanie Beileke (830392), Sebastian Hoogeboom (4512346), Martin Schicht (287742), Saskia Etzold (5774537)   +14 more
core   +1 more source

Spatially Confined/Ligand‐Directed Ultrabright NIR‐AIE Nanoprobe for In Vitro Rapid Detection and In Situ Imaging of Bacterial Septic Arthritis

Advanced Science, EarlyView.
Inorganic PbS quantum dots spatially confine AIEgens and enable cooperative luminescence within a ligand‐directed core–shell–shell nanoassembly, generating ultrabright NIR PPANPs with enhanced fluorescence and photothermal performance. The platform enables 10‐min S.
Yujian Li, Jia Shu, Sijia Lv, Leilei Qin, Xuefeng Luo, PengCheng Xiao, Huan Cai, Xin Gao, Yan Zhao, Haotian Zhou, Yaji Yang, Zhenglin Zhu, Shijia Ding, Juan Li, Rui Chen, Wei Huang   +15 more
wiley   +1 more source

Local and systemic inflammatory lipid profiling in a rat model of osteoarthritis with metabolic dysregulation. [PDF]

PLoS ONE, 2018
Bioactive oxidised lipids (oxylipins) are important signalling mediators, capable of modulating the inflammatory state of the joint and anticipated to be of importance in joint homeostasis and status of osteoarthritis.
H M de Visser, S C Mastbergen, S Ravipati, P M J Welsing, F C Pinto, F P J G Lafeber, V Chapman, D A Barrett, H Weinans   +8 more
doaj   +1 more source

Plasma and Synovial Fluid VEGF-A and Neuropilin-1 in Knee Osteoarthritis: Associations With Radiographic Severity, Pain Sensitization-Related Features, and Disease Burden. [PDF]

Kaohsiung J Med Sci
ABSTRACT This study aimed to investigate associations of plasma and synovial fluid vascular endothelial growth factor A (VEGF‐A) and neuropilin‐1 (NRP1) levels with radiographic severity, pain sensitization‐related features, and disease burden in knee osteoarthritis (KOA). Plasma VEGF‐A and NRP1 were measured by sandwich ELISA in 120 patients with KOA (
Tan CJ.
europepmc   +2 more sources