Results 161 to 170 of about 90,784 (291)

Distinct late-stage osteoarthritis profiles identified through NF-κB, TNF-α, and TGF-β–driven synovial inflammation and pain

Scientific Reports
This study delineates distinct late-stage osteoarthritis (OA) profiles, characterized by NF-κB, TNF-α, and TGF-β–mediated synovial inflammation and pain, in a cohort of 31 patients undergoing joint arthroplasty.
Sofija Semenistaja, Liba Sokolovska, Simons Svirskis, Peteris Studers, Valerija Groma, Sandra Skuja   +5 more
doaj   +1 more source

Membrane‐type I metalloproteinase (MT1‐MMP): A key modifier of extracellular matrix microenvironment

The FEBS Journal, EarlyView.
MT1‐MMP: A cellular microenvironment modifier. MT1‐MMP is a major cellular microenvironment modifier, maintaining collagen homeostasis by degrading excess collagen (A), creating a migration path in motile cells such as cancer cells (B), modulating local microenvironmental signaling by cleaving transmembrane receptors (C), and destroying tissue ...
Yoshifumi Itoh, Masaki Inada
wiley   +1 more source

Role of inflammatory factors and adipose tissue in pathogenesis of rheumatoid arthritis and osteoarthritis. Part I: Rheumatoid adipose tissue

Journal of Ultrasonography, 2013
For many years, it was thought that synovial cells and chondrocytes are the only sources of proinflammatory cytokines and growth factors found in the synovial fluid in patients suffering from osteoarthritis and rheumatoid arthritis.
Iwona Sudoł‑Szopińska, Ewa Kontny, Katarzyna Zaniewicz‑Kaniewska, Monika Prohorec‑Sobieszek, Fadhil Saied, Włodzimierz Maśliński   +5 more
doaj  

Biogenesis of TNF‐α‐insights into proteostasis and inflammation

The FEBS Journal, EarlyView.
TNF‐α biogenesis, trafficking, and signalling are tightly and reciprocally coupled to cellular proteostasis systems, including ER chaperones and endoplasmic reticulum‐associated degradation. This bidirectional crosstalk determines whether TNF‐α responses are adaptive or proteotoxic.
Bailasan Haidar, Céline Philippe, Eric Chevet, Jiří Zahradník   +3 more
wiley   +1 more source

Mapping the murine TMJ glenoid fossa over development, homeostasis and in response to disease

Journal of Anatomy, EarlyView.
The fibrocartilage of the murine glenoid fossa and condyle of the temporomandibular joint are shown to form at distinct times with distinct molecular identities. Changes in the condyle during disease lead to remodelling of the fossa to maintain joint alignment.
Ticha Tuwatnawanit, Denisa Belisova, Zuzana Sumbalova Koledova, Neal Anthwal, Abigail S. Tucker   +4 more
wiley   +1 more source

Antimicrobial peptides in human synovial membrane as (low-grade) periprosthetic joint infection biomarkers. [PDF]

Eur J Med Res, 2020
Banke IJ, Stade N, Prodinger PM, Tübel J, Hapfelmeier A, von Eisenhart-Rothe R, van Griensven M, Gollwitzer H, Burgkart R.   +8 more
europepmc   +1 more source

Lubrication of synovial membrane. [PDF]

Annals of the Rheumatic Diseases, 1971
E L, Radin, I L, Paul, D A, Swann, E S, Schottstaedt   +3 more
openaire   +2 more sources

Is the temporomandibular joint affected by rheumatoid arthritis? A comparative investigation with knee arthritis in an experimental rat model

Journal of Anatomy, EarlyView.
Animals were sensitized with mBSA emulsified in CFA/IFA and subsequently received three intra‐articular injections of mBSA into either the TMJ or the knee (once per week). Mechanical hyperalgesia was assessed using electronic von Frey testing after arthritis establishment at 24 h or 7 days following the third intra‐articular injection.
Ana Carolina de Figueiredo Costa, Luane Macedo de Sousa, Delane Viana Gondim   +2 more
wiley   +1 more source

High-Plex RNA Expression Profiling of Formalin-Fixed Paraffin-Embedded Synovial Membrane Indicates Potential Mechanism of Mesenchymal Stromal Cells in the Mitigation of Posttraumatic Osteoarthritis. [PDF]

Cartilage, 2021
Keller LE, Fortier LA, Delco ML, Okudaira M, Becktell L, Cercone M.   +5 more
europepmc   +1 more source

Secondary cartilage in the murine medial pterygoid plate has a critical role in the pathfinding of the tensor veli palatini

Journal of Anatomy, EarlyView.
The development of the medial pterygoid plate (MPP) is followed in mouse embryos, highlighting its neural crest origin and complex development via both endochondral and membranous ossification. Using transgenic mice, the secondary cartilage of the MPP is shown to direct the path of the tensor veli palatini.
Luke A. Barlow, Emi Nomura, Abigail S. Tucker   +2 more
wiley   +1 more source