Results 191 to 200 of about 46,096 (291)

Therapeutic Potential of Lipid Nanoparticle‐Encapsulated CD19‐Targeting mRNAs in Lupus and Rheumatoid Arthritis

Advanced Science, Volume 12, Issue 21, June 5, 2025.
This study develops lipid nanoparticle‐encapsulated mRNA‐encoding antibodies (mRNab‐LNPs) targeting CD19, demonstrating robust anti‐CD19 antibody production in vivo. Intramuscular injection of mRNab‐LNPs reduces CD19+ B and plasma cells in lupus and rheumatoid arthritis mice, significantly alleviating histopathological changes and tissue injuries of ...
Chipeng Guo, Yingsen Tang, Ling Zeng, Xiaomei You, Siweier Luo, Yufei Du, Le Wang, Liangchun Wang, Jianchuan Wang, Jinjin Chen, Yiming Zhou   +10 more
wiley   +1 more source

Label‐Free Microscale Technologies for Isolation of Heterogeneous Circulating Tumor Cells

Advanced NanoBiomed Research, Volume 5, Issue 6, June 2025.
The isolation of circulating tumor cells (CTCs) from liquid biopsy samples is crucial for cancer treatment and monitoring. This review evaluates primary label‐free isolation methods for capturing heterogeneous CTCs and examines their potential to provide deeper insights into tumor heterogeneity and dynamics of cancer progression.
Gürhan Özkayar, Esma Derin, Georg R. Pesch, John W. M. Martens, Peter ten Dijke, Pouyan E. Boukany   +5 more
wiley   +1 more source

Matrix Metalloproteinase-dependent turnover of cartilage, synovial membrane, and connective tissue is elevated in rats with collagen induced arthritis [PDF]

, 2012
Anne Sofie Siebuhr, Jianxia Wang, M.A. Karsdal, Anne‐Christine Bay‐Jensen, Yongri Jin, Q. Zheng   +5 more
openalex   +1 more source

Macrophages‐derived small extracellular vesicles regulate chondrocyte proliferation and affect osteoarthritis progression via upregulating Osteopontin expression

Journal of Cell Communication and Signaling, Volume 19, Issue 2, June 2025.
Abstract Small extracellular vesicles (sEVs) are considered promising gene‐delivery vehicles for the treatment of osteoarthritis (OA). This study aimed to explore the molecular mechanism by which M2 macrophage‐derived sEVs (M2‐sEVs) modulate chondrocyte proliferation and apoptosis, thereby affecting OA progression.
Min Tu, An‐Min Liu, Wei Huang, Dan Wang, Hou‐Qiong Chen, Xiao‐Yuan Hu   +5 more
wiley   +1 more source

Effects of chondroitin sulfate on the gene expression profile in the inflamed synovial membrane [PDF]

, 2013
Cécile Lambert, J.-E. Dubuc, E. Montell, Josep Vergés, Yves Henrotin   +4 more
openalex   +1 more source

Synovial Membrane and Articular Cartilage [PDF]

BMJ, 1939
openaire   +3 more sources

Daphnetin alleviates inflammation and promotes autophagy via the AMPK/mTOR pathway in gouty arthritis

Journal of Cell Communication and Signaling, Volume 19, Issue 2, June 2025.
Daphnetin, a coumarin derivative, regulates the AMPK/mTOR signaling pathway to inhibit inflammation and promote autophagy in monosodium urate‐induced mice and THP‐1 cells, thereby suppressing MSU‐induced gouty arthritis. Abstract Gouty arthritis (GA) is an inflammatory disease resulting from monosodium urate (MSU) crystal deposition in joints and ...
Zhiyong Liu, Aichun Chu, Zhiqian Bai, Chao Yang   +3 more
wiley   +1 more source

Treatment of Equine Tarsus Long Medial Collateral Ligament Desmitis with Allogenic Synovial Membrane Mesenchymal Stem/Stromal Cells Enhanced by Umbilical Cord Mesenchymal Stem/Stromal Cell-Derived Conditioned Medium: Proof of Concept. [PDF]

Animals (Basel)
Leal Reis I, Lopes B, Sousa P, Sousa AC, Branquinho MV, Caseiro AR, Rêma A, Briote I, Mendonça CM, Santos JM, Atayde LM, Alvites RD, Maurício AC.   +12 more
europepmc   +1 more source

Contribution of Infrapatellar Fat Pad and Synovial Membrane to Knee Osteoarthritis Pain. [PDF]

Biomed Res Int, 2019
Belluzzi E, Stocco E, Pozzuoli A, Granzotto M, Porzionato A, Vettor R, De Caro R, Ruggieri P, Ramonda R, Rossato M, Favero M, Macchi V.   +11 more
europepmc   +1 more source

Intra-articular injection of inorganic pyrophosphate improves IL-1β-induced cartilage damage in rat model of knee osteoarthritis in vivo

Osteoarthritis and Cartilage Open
Objective: Osteoarthritis (OA) is the most common form of chronic joint disease, affecting mainly the elderly population. This disorder is caused by cartilage degeneration with complex changes in the chondrocyte phenotype.
Émilie Velot, Mathilde Guibert, Meriem Koufany, Arnaud Bianchi   +3 more
doaj