Results 191 to 200 of about 2,392,786 (296)

Understanding exosomes in diabetic wound healing

Periodontology 2000, EarlyView.
Abstract Background Diabetic wounds signify a major complication of diabetes mellitus, characterized by chronic inflammation, compromised angiogenesis, and high risk of infection, amputation, and mortality. Contemporary therapies remain limited in efficacy and durability.
Paras Ahmad, Yulan Wang, Yufeng Zhang, Anton Sculean, Richard J. Miron   +4 more
wiley   +1 more source

The effect of hypoxia on chondrogenesis of equine synovial membrane-derived and bone marrow-derived mesenchymal stem cells. [PDF]

BMC Vet Res, 2019
Gale AL, Mammone RM, Dodson ME, Linardi RL, Ortved KF.   +4 more
europepmc   +1 more source

Identification of Novel Therapeutic Agent Candidates Through High Throughput Screening With Chemical Library Based on Molecular Subclassification in Canine Histiocytic Sarcoma Cell Lines

Veterinary and Comparative Oncology, EarlyView.
ABSTRACT Effective chemotherapy for canine histiocytic sarcoma (CHS) has yet to be established. In our previous study, CHS cell lines were subclassified into two groups based on their gene expression profiles: Group A and Group B. This study aimed to identify novel therapeutic agents that are effective against each CHS subgroup, and we performed high ...
Hiroki Sakuma, Hirotaka Tomiyasu, Mari Takamiya, Yuko Goto‐Koshino, Atsushi Tsukamoto, Makoto Bonkobara, Masaru Okuda   +6 more
wiley   +1 more source

Isometric training at longer muscle–tendon complex lengths: A potential countermeasure to impaired neuro‐muscle–tendon function during space travel

Experimental Physiology, EarlyView.
Abstract Manned space exploration to distant destinations, including Mars, continues to be an aspiration of humankind. Space travel does, however, present many challenges to the body, amongst which adaptation to microgravity is perhaps the largest. For instance, both short and long manned spaceflight missions have shown substantial deleterious effects ...
Gerard McMahon, Andy Sanderson, Hans Degens   +2 more
wiley   +1 more source

Collagen V oral administration decreases inflammation and remodeling of synovial membrane in experimental arthritis. [PDF]

PLoS One, 2018
Atayde SR, Velosa APP, Catanozi S, Del Bianco V, Andrade PC, Rodrigues JECM, Dos Santos Filho A, Antonangelo L, de Mello SBV, Capelozzi VL, Teodoro WR.   +10 more
europepmc   +1 more source

Computational modelling of cardiac fibroblast signalling reveals a key role for Ca2+ in driving atrial fibrillation‐associated fibrosis

The Journal of Physiology, EarlyView.
Abstract figure legend A pre‐existing fibroblast signalling model was enhanced by integrating atrial‐specific components and reactions linked to atrial fibrosis and atrial fibrillation (AF). The analysis highlights the central role of Ca2⁺ signalling in driving profibrotic responses to AF‐relevant stimuli, angiotensin‐II and transforming growth factor ...
Najme Khorasani, Haibo Ni, Jeffrey J Saucerman, Dobromir Dobrev, Stefano Morotti, Eleonora Grandi   +5 more
wiley   +1 more source

Coordinated regulation of PIEZO2 by alternative splicing, post‐translational modification, membrane trafficking and protein partners

The Journal of Physiology, EarlyView.
Abstract figure legend Regulatory mechanisms such as alternative splicing, post‐translational modification, membrane trafficking, and protein interactions control channel gating, membrane abundance, and overall activity of PIEZO2. Proper regulation supports PIEZO2‐dependent proprioceptive, somatosensory, nociceptive, pruriceptive and interoceptive ...
Eunice I. Oribamise, Qinglu Li, Mary G. Garry   +2 more
wiley   +1 more source

Urokinase Plasminogen Activator Receptor‐Associated Protein (uPARAP) as a Potential Next Generation Molecular Target for Treatment of Gastrointestinal Stromal Tumors (GIST)

International Journal of Cancer, Volume 159, Issue 3, Page 797-808, 1 August 2026.
A key component of the collagen internalization and lysosomal degradation cellular machinery, uPARAP may contribute to cancer progression. Here, the authors explored the expression of uPARAP in gastrointestinal stromal tumors using well‐annotated clinical patient samples and specimens from cell line‐ and patient‐derived xenografts.
Chao‐Chi Wang, Flavia Paternostro, Agnieszka Wozniak, Lore De Cock, Luna De Sutter, Kimberly Verbeeck, Ulla Vanleeuw, Daniël Gorgels, Che‐Jui Lee, Raf Sciot, Patrick Schöffski   +10 more
wiley   +1 more source

Biodegradable Natural Polymer‐Based Drug Delivery Systems for Bone Tissue Engineering

Medicinal Research Reviews, Volume 46, Issue 4, Page 966-988, July 2026.
ABSTRACT The increasing incidence of bone diseases and injuries, especially among aging populations, has underscored the shortcomings of traditional treatments such as bone grafts and metal implants, which often face complications including immune rejection, mechanical failure, and delayed healing.
Hyejin Jo, Shinwon Kang, Jae Eun Yang, Inseon Kim, Seunghun S. Lee   +4 more
wiley   +1 more source

Mapping the murine TMJ glenoid fossa over development, homeostasis and in response to disease

Journal of Anatomy, Volume 249, Issue 1, Page 85-96, July 2026.
The fibrocartilage of the murine glenoid fossa and condyle of the temporomandibular joint are shown to form at distinct times with distinct molecular identities. Changes in the condyle during disease lead to remodelling of the fossa to maintain joint alignment.
Ticha Tuwatnawanit, Denisa Belisova, Zuzana Sumbalova Koledova, Neal Anthwal, Abigail S. Tucker   +4 more
wiley   +1 more source