Results 81 to 90 of about 46,096 (291)
Clinical Anatomy, EarlyView.Abstract Although the sternoclavicular joint shares structural similarities with the knee and hip joints as a diarthrodial joint, its biomechanics differ significantly due to its non‐weight‐bearing nature. Nevertheless, it is subject to considerable loading, leading to increased susceptibility to osteoarthritis, a prevalent condition characterized by ...
Sophie Mok +4 more
wiley +1 more source
Chemistry &Biodiversity, EarlyView.ABSTRACT The subfamily Gomphrenoideae is composed of about 480 accepted species, many of which have been historically used as medicinal plants, reason why they have been studied in terms of chemical profile, biological activity, and safety. This review consolidates the advances in research on this subfamily over the past 47 years, emphasizing its ...
Dayanna Isabel Araque Gelves +3 more
wiley +1 more source
Exploration, EarlyView.Using celastrol as a case study, this review summarizes various target discovery strategies for natural products, including chemical proteomics, protein microarray, degradation‐based protein profiling, proteome‐wide label‐free approaches, network pharmacology, target‐based drug screening, and indirect strategies.
Yanbei Tu +5 more
wiley +1 more source
Blood‐based biomarkers in soft tissue sarcoma: Implications for immune checkpoint inhibitor therapy
International Journal of Cancer, EarlyView.Abstract Soft tissue sarcoma (STS) is a rare and heterogeneous cancer, comprising approximately 1% of all adult cancers and 7%–15% of all childhood cancers. In the advanced stages, chemotherapy remains the standard‐of‐care, but efficacy is limited, with a response rate of 15%–30%, and responses are often short‐lived, with median progression‐free ...
Brie‐Anne Mannah +2 more
wiley +1 more source
The Kaohsiung Journal of Medical Sciences, EarlyView.ABSTRACT This study examined YTHDF2's role in modulating IL‐6R signaling to regulate synovial fibroblast inflammation and bone damage in rheumatoid arthritis (RA). Synovial tissues of RA patients were collected. Human fibroblast‐like synoviocyte (FLS), MH7A cell line, was induced with TNF‐α and transfected. Cell proliferation was assessed using MTT and
Yan Zhang +9 more
wiley +1 more source
Knee Surgery, Sports Traumatology, Arthroscopy, EarlyView.Abstract Purpose This systematic review with meta‐analysis evaluates the long‐term efficacy of matrix‐assisted autologous chondrocyte transplantation (MACT) in terms of functional scores using scaffolds made of hyaluronic acid (HA) or collagen (C). Methods Nineteen articles met the eligibility criteria for the analysis.
Alessandra Colombini +7 more
wiley +1 more source
THE PERMEABILITY OF THE SYNOVIAL MEMBRANE
Quarterly Journal of Experimental Physiology and Cognate Medical Sciences, 1940 The permeability of the synovial membranes was studied by injecting intravenously a series of dyes in rabbits and cats, and perfusing the knee joints afterwards.It was found that only dyes of acid character reach the joint cavity and appear in the perfusate. The amount excreted was in direct proportion to the diffusibility of the dye.Alkaline dyes were
openaire +2 more sources
Breaking Boundaries: Chronic Diseases and the Frontiers of Immune Microenvironments
Med Research, EarlyView.ABSTRACT The immune microenvironment includes immune cells, cytokines, extracellular matrix, vesicles, etc. The interactions between these components form a unique local immune microecology. Although immunity serves as the defense against external pathogens, aberrant immune activation often contributes to disease development.
Guoqing Li +13 more
wiley +1 more source
Concurrent Imaging and Clinical Study of the Efficacy of Hyaluronic Acid Injection for Knee Osteoarthritis: A Synovial Membrane Investigation with Ultrasound Imaging. [PDF]
Pharmaceuticals (Basel), 2023 Wang CC +5 more
europepmc +1 more source