Results 51 to 60 of about 2,054,522 (273)

An Integrated Oxygen‐Supplying Device and Predictive Multiphysics Model for Extended Ambient Transport of Insulin‐Producing Cells

Advanced Functional Materials, EarlyView.
Cell therapies typically rely on cold‐chain logistics and cryopreservation, limiting access and compromising cell quality. Here, a dual‐chamber device separates an oxygen‐supplying chamber from a hyaluronic acid cargo chamber, sustaining oxygen delivery for over 70 h and enabling ambient‐temperature shipment.
Daniel A. Domingo‐Lopez, Ruth Tarpey, Benjamin Brennan, Bryan D. Boyle, Amir M. Alsharabasy, Abhik Mallick, Gabriella Bellavia, Abhay Pandit, Garry P. Duffy, Ruth E. Levey   +9 more
wiley   +1 more source

COX-2 in synovial tissues

Osteoarthritis and Cartilage, 1999
Prostaglandins (PGs) are important mediators of acute and chronic inflammation. The production of PGs in synovial tissues is catalyzed by an enzyme cascade that includes phospholipase A(2)s (PLA(2)s), cyclooxygenases (COXs), and terminal PG synthases. There are two isoforms of COX expressed in synovial tissues.
openaire   +2 more sources

Single‐Cell Resolution Mapping of Osteoarthritis‐Associated Chondrocyte Dynamics Using a High‐Density CMOS MEA Platform

Advanced Healthcare Materials, EarlyView.
Single‐cell and spatially resolved impedance mapping using a high‐density CMOS‐MEA platform enables non‐invasive monitoring of osteoarthritis‐associated chondrocyte dynamics. Continuous label‐free measurements reveal heterogeneous remodeling behaviors, including proliferation, migration, and phenotypic transitions, establishing a powerful approach for ...
Neha Deshpande, Pauline Coquart, Bram Theuns, Susanne Cremery, Jaime Rodolfo V. Garcia III, Julien Verplanken, Dennis Lambrechts, Dries Braeken, Liesbet Lagae, Johanna Bolander   +9 more
wiley   +1 more source

Submandibular synovial sarcoma mimicking a vascular lesion: A rare case report

SRM Journal of Research in Dental Sciences, 2018
Synovial sarcoma is a soft-tissue sarcoma of periarticular surfaces in close association with tendon sheaths, bursae, and joint capsules. Synovial sarcoma represents 5.6%–10% of all soft-tissue sarcomas.
Naresh Kumar, Neeraj Kumar Dhiman, Shankar Singh, Ajit Kumar Vishwakarma   +3 more
doaj   +1 more source

Artemisinin‐Loaded Core‐Shell Microspheres Modulate Histone Lactylation to Remodel the Microenvironment for Cartilage Protection in Rheumatoid Arthritis

Advanced Healthcare Materials, EarlyView.
ART@PLGA@GH‐A microspheres are developed via microfluidic technology for intra‐articular delivery of artemisinin. The system remodels rheumatoid arthritis microenvironments by regulating metabolic and inflammatory disorders, reducing lactate‐driven histone lactylation and cellular senescence, while restoring cartilage homeostasis and protecting joint ...
Shijie Meng, Jianxin Li, Yuyang Luo, Yisi Liu, Feng Xing, Yingchen Ni, Fengyuan Zhang, Zhicheng Fan, Hua Xu, Weidong Zhang, Youhua Wang   +10 more
wiley   +1 more source

ES-62 protects against collagen-induced arthritis by resetting interleukin-22 towards resolution of inflammation in the joints [PDF]

, 2014
Objective. The parasitic worm–derived immunomodulator ES-62 protects against disease in the mouse collagen-induced arthritis (CIA) model of rheumatoid arthritis (RA) by suppressing pathogenic interleukin-17 (IL-17) responses. The Th17 associated cytokine
Al-Riyami, Lamyaa, Pineda, Miguel A, Rodgers, David T, Harnett, Margaret, Harnett, William   +4 more
core   +3 more sources

Targeting STAT6-mediated synovial macrophage activation improves pain in experimental knee osteoarthritis

Arthritis Research & Therapy
Background Pain from osteoarthritis (OA) is one of the top causes of disability worldwide, but effective treatment is lacking. Nociceptive factors are released by activated synovial macrophages in OA, but depletion of synovial macrophages paradoxically ...
Garth Blackler, Yue Lai-Zhao, Joseph Klapak, Holly T. Philpott, Kyle K. Pitchers, Andrew R. Maher, Benoit Fiset, Logan A. Walsh, Elizabeth R. Gillies, C. Thomas Appleton   +9 more
doaj   +1 more source

Diffusion of ertapenem into bone and synovial tissues [PDF]

Journal of Antimicrobial Chemotherapy, 2007
The degree of penetration of an antibiotic into the infected site is an important criterion for therapeutic success. Ertapenem is a new carbapenem, exhibiting activity against most Gram-positive and Gram-negative aerobic and anaerobic bacteria commonly recovered from community-acquired infections.
E, Boselli, D, Breilh, S, Djabarouti, J C, Bel, M C, Saux, B, Allaouchiche   +5 more
openaire   +2 more sources

Intraosseous synovial sarcoma of the proximal femur: Case report [PDF]

, 2012
Synovial sarcoma is primarily a soft tissue malignancy that most often affects adolescents and young adults. It very rarely presents as a primary bone tumour and has only been reported in nine other cases to date.
Ibrahim, Z.A., KL Pan, PS Shanmugam, ZA Ibrahim, Zulkarnaen, M., Pan, K.L., Chan, W.H, Shanmugam, P.S, WH Chan   +8 more
core   +2 more sources

Combating Inflammation and Promoting Anabolism in Osteoarthritic Cartilage Defect With an MMP13‐Sensing Dual‐Drug Scaffold

Advanced Science, EarlyView.
ABSTRACT Osteoarthritis (OA) is a widespread degenerative joint condition marked by progressive cartilage breakdown, and a chronic inflammatory microenvironment, where conventional therapies largely fail to halt disease progression. To address this unmet need, an intra‐articularly implantable, disease‐responsive scaffold was developed for combinatorial
Zhen Zhang, Bangheng Liu, Yulei Mu, Huiqun Zhou, Liang Ma, Chenjie Xu, Dong‐An Wang   +6 more
wiley   +1 more source