Results 121 to 130 of about 43,674 (271)

Nrf2 Regulates CHI3L1 to Suppress Inflammation and Improve Post-Traumatic Osteoarthritis

Journal of Inflammation Research, 2021
Yang Song,1,2 Dake Hao,3 Huan Jiang,4 Mingguang Huang,2 Qingjun Du,2 Yi Lin,2 Fei Liu,1 Bin Chen1 1Division of Orthopaedics and Traumatology, Department of Orthopaedics, Nanfang Hospital, Southern Medical University, Guangzhou, 510515, People’s Republic ...
Song Y, Hao D, Jiang H, Huang M, Du Q, Lin Y, Liu F, Chen B   +7 more
doaj  

Impact of tear morphology and meniscal laterality on repair failure in stable knees: Medial repairs show over twofold risk

Knee Surgery, Sports Traumatology, Arthroscopy, EarlyView.
Abstract Purpose To evaluate the failure rates of all‐inside meniscal repair based on tear morphology in stable knees (i.e., without concomitant anterior cruciate ligament reconstruction [ACLR]) and to assess the influence of failure. Methods This retrospective cohort study included 1008 patients who underwent arthroscopic all‐inside meniscal repair ...
Christoffer von Essen, Riccardo Cristiani, Dzan Rizvanovic, Anders Stålman   +3 more
wiley   +1 more source

Quantitation of TTR in synovium by immunoelectron microscopy.

, 2014
RA (n = 3) and OA (n = 3) synovium were surgically removed in aseptic condition, fixed and processed for electron microscopy. Ultrathin sections were labelled with 20 nm gold conjugated secondary antibody.
Sagarika Biswas (281819), Taposh Kumar Das (548992), Darshan Singh Bhakuni (548991), Rajesh Malhotra (281822), Onkar Prasad Garg (548989), Lalit Kumar Singh (519938), Ashish Sarkar (548988), Sreejoyee Ghosh (548987), Radhey Shyam Sharma (548990), Saurabh Sharma (281820), Yogendra Singh (8247)   +10 more
core   +1 more source

Managing the meniscus Part 2: Traumatic tear patterns, biologic augmentation, transplantation, innovation and future research

Knee Surgery, Sports Traumatology, Arthroscopy, EarlyView.
Abstract Acute, traumatic meniscus tears are common and should be repaired whenever possible. However, the biological age of the patient, along with the specific tear morphology, may significantly influence the selection of the repair technique, expected clinical outcomes and the postoperative rehabilitation protocol.
Armin Runer, Matthew P. Kolevar, Ehab M. Nazzal, Jonathan D. Hughes, Sebastian Kopf, Aaron J. Krych, Michael T. Hirschmann, Robert F. LaPrade, Alan Getgood, Tim Spalding, Robert Prill, Maria Tuca, Matthieu Ollivier, Sebastian Siebenlist, Sachin Tapasvi, Volker Musahl   +15 more
wiley   +1 more source

Accessible xenografts of human synovium in the subcutaneous tissues of the ears of SCID mice

, 1999
This work was undertaken to examine whether human synovium could be engrafted into subcutaneous pouches in the ears of severe combined immunodeficient (SCID) mice. Synovium was transplanted into surgically constructed ear pouches.
Cleland, L., Proudman, S., Graham Mayrhofer, Leslie G Cleland, Michael Fusco, Fusco, M., Susanna M Proudman, Mayrhofer, G.   +7 more
core   +1 more source

Bucket‐handle and medial meniscal tears exhibit higher failure rates after all‐inside repair with concomitant ACL reconstruction

Knee Surgery, Sports Traumatology, Arthroscopy, EarlyView.
Abstract Purpose To evaluate failure rates across specific meniscal tear morphologies in patients undergoing all‐inside meniscal repair with anterior cruciate ligament reconstruction (ACLR), and to identify factors associated with failure. Methods This retrospective cohort included 1355 patients who underwent all‐inside meniscal repair during ACLR ...
Christoffer von Essen, Riccardo Cristiani, Dzan Rizvanovic, Johan Wänman, Anders Stålman   +4 more
wiley   +1 more source

Senotherapeutics for Knee Osteoarthritis

Medicinal Research Reviews, EarlyView.
ABSTRACT Osteoarthritis (OA) is a chronic disease that imposes a significant economic burden and deteriorates quality of life. Nevertheless, current therapeutic options for OA are limited to symptomatic remedies. As such, there is a high interest in novel methods for treating or preventing OA.
Ezgi Duman, Girish Pattappa, Patrick Pann, Stephan Reppenhagen, Maximilian Rudert, Peter Angele, Denitsa Docheva   +6 more
wiley   +1 more source

Natural Products Exhibit Therapeutic Potential in Treating Rheumatoid Arthritis by Targeting the PI3K/Akt Signaling Pathway

Phytotherapy Research, EarlyView.
This review summarizes how natural products, mainly including flavonoids, terpenoids, alkaloids, and polyphenols alleviate RA via PI3K/Akt pathway, regulating inflammation, proliferation, apoptosis, angiogenesis, and osteoclast differentiation. The figure was created by Figdraw (https://www.figdraw.com/#/).
Haishuo Ren, Yige Wang, Wenjing Ma, Omachi Daniel Ogaji, Shujing Chen, Kunze Du, Xuemi Zhang, Bo Xu, Shanxing Zhai, Shiming Fang, Yanxu Chang   +10 more
wiley   +1 more source

MOESM2 of Interleukin-1 receptor antagonist (IL-1Ra) is more effective in suppressing cytokine-induced catabolism in cartilage-synovium co-culture than in cartilage monoculture

, 2019
Additional file 2: Figure S2A. Nitrite released to media from cartilage (C) and synovium (S) tissue cultured individually and treated with IL-1α (2 ng/mL) for 8 days. B.
Ryan Porter (4732245), Patrik Önnerfjord (373422), Shikhar Mehta (7862981), Sumayyah Akhtar (7862984), Ambika Bajpayee (7862987)   +4 more
core   +1 more source

Natural Polysaccharides for Rheumatoid Arthritis Therapy: Mechanism, Drug Delivery and Clinical Application

Phytotherapy Research, EarlyView.
Schematic overview of the experimental models, therapeutic mechanisms, drug delivery systems, and clinical potential of natural polysaccharides in rheumatoid arthritis. ABSTRACT Rheumatoid arthritis (RA) is a systemic autoimmune disease characterized primarily by chronic synovitis.
Luxin Li, Junnan Li, Guangzhi Li, Lili Huang, Tiantian Wen, Yanying Li, Yan Sun, Zhenqiang Liu, Qingshan Chen, Lili Zhang, Tiangang Lu, Ruiyan Wu, Haixue Kuang, Xiaochi Ma, Yan Liu   +14 more
wiley   +1 more source