Results 111 to 120 of about 43,674 (271)

Activation of the IL-4 STAT Pathway in Rheumatoid Synovium

, 2000
STATs act as second messenger after binding of a signaling molecule to its receptor. IL-4 STAT is directly involved in the Il-4-dependent gene transcription in the nucleus. We examined the expression and activation of IL-4 STAT and its related kinase Jak-
Ballhorn, Wibke, Schölmerich, Jürgen, Kullmann, Frank, Distler, Oliver, Gay, Steffen, Judex, Martin, Gay, Renate E., Schlottmann, Klaus, Müller-Ladner, Ulf   +8 more
core   +1 more source

Tofacitinib Regulates β‐Catenin Nuclear Translocation to Inhibit FLS Migration and Alleviate Clinical Symptoms of RA

iNew Medicine, EarlyView.
ABSTRACT Objective Tofacitinib is a Janus kinase (JAK) inhibitor approved for the treatment of moderate‐to‐severe rheumatoid arthritis (RA). However, its synovium‐related molecular mechanisms, particularly its regulatory effect on fibroblast‐like synoviocyte (FLS) migration, remain incompletely understood.
Shuqi Fang, Tianjing Zhang, Ling Hu, Ruijin Liu, Leyi Jia, Menglin Bai, Jiale Dong, Yuchen Zhao, Han Wang, Lei Zhang, Tao Li, Youcai Deng, Xianzheng Zhang, Lingling Zhang   +13 more
wiley   +1 more source

Low‐Field MRI for Knee Imaging: Current Insights and Evidence From a Systematic Review

Journal of Magnetic Resonance Imaging, EarlyView.
ABSTRACT Background Low‐field magnetic resonance imaging (MRI) has regained interest for musculoskeletal imaging due to advances in magnet design, hardware optimization, and artificial intelligence (AI)–based reconstruction, offering improved accessibility, patient comfort, and sustainability.
Switinder Singh Ghotra, Cláudia dos Sá dos Reis, Allison McGee, Jonathan P. McNulty   +3 more
wiley   +1 more source

Extraskeletal chondrosarcoma arising in the synovium of the wrist

, 1997
This article presents a rare case of extraskeletal chondrosarcoma in the synovium of the ...
Rombouts, Jean-Jacques, Malghem, Jacques, Barbier, Olivier, Noël, Henri   +3 more
core  

Mertk drives alveolar bone loss in experimental periodontitis associated with altered neutrophil function and osteoclast recruitment

Journal of Periodontology, EarlyView.
Abstract Background Alveolar bone loss is the hallmark of periodontitis and often remains refractory to conventional mechanical and antimicrobial therapies in chronic cases. Mer receptor tyrosine kinase (Mertk) has been implicated in bone homeostasis, yet the immune mechanisms by which Mertk modulates periodontal bone resorption remain insufficiently ...
Nicholas Mazzara, Kesley Martin, Rana Dabaja, Justin Redmond, Victoria Maglaras, Maxwell Mianecki, Harout Ashekian, Joseph T. Decker, Ann M. Decker   +8 more
wiley   +1 more source

Targeted delivery of anti-inflammatory therapy to rheumatoid tissue by fusion proteins containing an IL-4-linked synovial targeting peptide [PDF]

, 2011
We provide first-time evidence that the synovial endothelium-targeting peptide (SyETP) CKSTHDRLC successfully delivers conjugated IL-4 to human rheumatoid synovium transplanted into SCID mice. SyETP, previously isolated by in vivo phage display and shown
Ciara M. Finucane, Y. K. Stella Man, Danielle DiCara, Rita Jones, Ahuva Nissim, Stephen J. Mather, Taher E. I. Taher, Michele Bombardieri, Costantino Pitzalis, Yuti Chernajovsky, Sarah E. Wythe   +10 more
core  

Interleukin-24 Induces Inflammatory Chemokine and Cytokine Responses in Fibroblast-Enriched Synovial Cells from Patients with Knee Osteoarthritis

Biomedicines
Background: Interleukin-24 (IL-24) is expressed in synovial myofibroblasts and has been associated with pain severity in female patients with knee osteoarthritis (OA). However, the direct effects of IL-24 on inflammatory responses in synovial fibroblasts
Yui Uekusa, Kentaro Uchida, Makoto Itakura, Naoya Shibata, Manabu Mukai, Dai Iwase, Jun Aikawa, Ayumi Tsukada, Yukie Metoki, Gen Inoue, Masashi Takaso   +10 more
doaj   +1 more source

IGF2BP3 Overexpression Accelerates Osteoarthritis Progression by Promoting Glycolysis via m6A‐Dependent Stabilization of ECM1 mRNA

The Kaohsiung Journal of Medical Sciences, EarlyView.
ABSTRACT N6‐methyladenosine (m6A) plays a critical role in osteoarthritis (OA) pathogenesis. This study investigates the role of the m6A reader insulin‐like growth factor 2 mRNA‐binding protein 3 (IGF2BP3) in OA progression. OA models were established in vivo through destabilization of the medial meniscus (DMM) surgery in mice and in vitro by ...
Xing‐Shi Yuan, Hao‐Jie Zhang, Jia‐Xiang Ding, Zheng‐Liang Luo, Min Chen, Xiao‐Qi Zhang, Xi‐Fu Shang, Zhe Ni, Ke‐Rong Wu   +8 more
wiley   +1 more source

Disulfidptosis‐ and Ferroptosis‐Related Gene Signatures in Rheumatoid Arthritis: Association Analysis and Diagnostic Model Construction

The Kaohsiung Journal of Medical Sciences, EarlyView.
ABSTRACT Rheumatoid arthritis (RA) is a chronic autoimmune disease characterized by persistent synovial inflammation and progressive joint damage. Although ferroptosis has been implicated in RA progression, the role of disulfidptosis and its interaction with ferroptosis remains unclear.
Ting‐Ting Wang, Dong‐Mei Wang, Xue Li, Yuan‐Li Wei, Ping‐Dan Liu, Shi‐Lin Li, Si‐Ying Xiong, Cai‐Zhen Liu, Fan‐Xin Zeng, Jian‐Hong Wu, Lin Tang   +10 more
wiley   +1 more source

Human vascularised synovium-on-a-chip: a mechanically stimulated, microfluidic model to investigate synovial inflammation and monocyte recruitment.

Healthy synovium is critical for joint homeostasis. Synovial inflammation (synovitis) is implicated in the onset, progression and symptomatic presentation of arthritic joint diseases such as rheumatoid arthritis (RA) and osteoarthritis (OA).
Hopkins, Timothy, Bevan, Catrin, Thompson, Clare L, Wright, Karina T, Knight, Martin M, Screen, Hazel Rc   +5 more
core   +1 more source