Results 91 to 100 of about 43,674 (271)
Collection and Lipidomic Analysis of Murine Knee Synovium and Infrapatellar Fat Pad
Methods and ProtocolsIntra-articular soft connective tissues such as synovium and adipose tissue play a crucial role in governing joint homeostasis and disease progression in various forms of arthritis.
Tong Yang +2 more
doaj +1 more source
Autoimmune Responses in the Rheumatoid Synovium
PLoS Medicine, 2009 Rene Toes and Tom Huizinga discuss a new study indicating that lymphoneogenesis in the inflamed synovial tissue of patients with rheumatoid arthritis is fostering potentially pathogenic immune responses.
Rene E M Toes, Tom W J Huizinga
openaire +4 more sources
Arthritis &Rheumatology, EarlyView.Objective Anti‐homocitrullinated protein/peptide antibodies are specific to rheumatoid arthritis (RA) and predictive of worse prognosis, suggesting a pathogenic role for autoreactivity to homocitrullinated peptides (HomoCitP). However, T cell responses to HomoCitP remain largely unexplored.
Sofya Ulanova +6 more
wiley +1 more source
Гений oртопедии, 2022 Diabetic neuroosteoarthropathy complicated by osteomyelitis is one of the severe conditions of the ankle joint in patients with diabetes. The role of the synovium in the pathogenesis of this disease remains poorly understood.
Tatiana A. Stupina +3 more
doaj +1 more source
Doppler Imaging and Histology of the Synovium [PDF]
The Journal of Rheumatology, 2012 To the Editor: It is possible to examine the inflammation of a joint, bursa, or tendon area with ultrasonography (US) using greyscale or Doppler imaging1. The detection of perfusion in synovium is a relatively new phenomenon in rheumatology and the detection of a Doppler signal in the synovium is also thought to reflect the inflammatory state2 ...
openaire +2 more sources
Complement Activation Linked to Type II Interferon Signaling in Still Disease
Arthritis &Rheumatology, EarlyView.Objective Still disease (SD) is an autoinflammatory syndrome characterized by innate immune dysregulation. Although complement can drive inflammation, its involvement in SD remains to be defined. Thus, we aimed to assess complement activation in SD. Methods Complement was assessed using transcriptomic, proteomic, and in vitro approaches. RNA sequencing
Freya M. C. H. Huijsmans +115 more
wiley +1 more source
Frontiers in MedicineObjectiveThe study aimed to explore the utility of contrast-enhanced ultrasound (CEUS) as a tool for detecting minimal inflammation in rheumatoid arthritis (RA) patients in sustained remission (SR) and to correlate the findings with Disease Activity ...
Joaquim Polido-Pereira +13 more
doaj +1 more source
Early Synovial Regulatory T Cell Engagement in Posttraumatic Osteoarthritis
Arthritis &Rheumatology, EarlyView.Objective Posttraumatic osteoarthritis (PTOA) develops despite restoration of joint biomechanics, suggesting that early postinjury biologic processes within the synovium shape disease trajectories. We investigated whether synovial Treg cells are engaged during the early phase following joint injury and whether experimental enrichment of this ...
Xueyou Zhang +5 more
wiley +1 more source
Obesity-associated metabolic syndrome spontaneously induces infiltration of pro-inflammatory macrophage in synovium and promotes osteoarthritis [PDF]
, 2017 OBJECTIVES\ud \ud Epidemiological and experimental studies have established obesity to be an important risk factor for osteoarthritis (OA), however, the mechanisms underlying this link remains largely unknown.
Sun, Antonia R. +18 more
core +2 more sources
Arthritis &Rheumatology, EarlyView.Objective Synovial fibroblasts directly contribute to inflammation and damage in immune‐mediated inflammatory arthritis. CD248/endosialin is expressed by fibroblasts in the synovium, is highly up‐regulated during inflammation, and has been proposed as a potential therapeutic target.
Samuel Kemble +12 more
wiley +1 more source