The SNARE Protein Syntaxin 3 Confers Specificity for Polarized Axonal Trafficking in Neurons. [PDF]
PLoS ONE, 2016 Cell polarity and precise subcellular protein localization are pivotal to neuronal function. The SNARE machinery underlies intracellular membrane fusion events, but its role in neuronal polarity and selective protein targeting remain unclear.
Linda Soo Hoo +7 more
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Structural remodeling of target-SNARE protein complexes by NSF enables synaptic transmission [PDF]
Nature CommunicationsSynaptic vesicles containing neurotransmitters fuse with the plasma membrane upon the arrival of an action potential at the active zone. Multiple proteins organize trans-SNARE complex assembly and priming, leading to fusion.
K. Ian White +8 more
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Molecular mechanisms that stabilize short term synaptic plasticity during presynaptic homeostatic plasticity [PDF]
eLife, 2018 Presynaptic homeostatic plasticity (PHP) compensates for impaired postsynaptic neurotransmitter receptor function through a rapid, persistent adjustment of neurotransmitter release, an effect that can exceed 200%.
Jennifer M Ortega +2 more
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Secretory vesicles are preferentially targeted to areas of low molecular SNARE density [PDF]
, 2012 Intercellular communication is commonly mediated by the regulated fusion, or exocytosis, of vesicles with the cell surface. SNARE (soluble N-ethymaleimide sensitive factor attachment protein receptor) proteins are the catalytic core of the secretory ...
Dun, Alison +8 more
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Conformational change of Syntaxin-3b in regulating SNARE complex assembly in the ribbon synapses
Scientific Reports, 2022 Neurotransmitter release of synaptic vesicles relies on the assembly of the soluble N-ethylmaleimide-sensitive factor attachment protein receptor (SNARE) complex, consisting of syntaxin and SNAP-25 on the plasma membrane and synaptobrevin on the synaptic
Claire Gething +6 more
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Selective interaction of syntaxin 1A with KCNQ2: possible implications for specific modulation of presynaptic activity. [PDF]
PLoS ONE, 2009 KCNQ2/KCNQ3 channels are the molecular correlates of the neuronal M-channels, which play a major role in the control of neuronal excitability. Notably, they differ from homomeric KCNQ2 channels in their distribution pattern within neurons, with unique ...
Noa Regev +9 more
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Basolateral sorting of syntaxin 4 is dependent on its N-terminal domain and the AP1B clathrin adaptor, and required for the epithelial cell polarity. [PDF]
PLoS ONE, 2011 Generation of epithelial cell polarity requires mechanisms to sort plasma membrane proteins to the apical and basolateral domains. Sorting involves incorporation into specific vesicular carriers and subsequent fusion to the correct target membranes ...
Elena Reales +4 more
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Analysis of familial hemophagocytic lymphohistiocytosis type 4 (FHL-4) mutant proteins reveals that S-acylation is required for the function of syntaxin 11 in natural killer cells. [PDF]
PLoS ONE, 2014 Natural killer (NK) cell secretory lysosome exocytosis and cytotoxicity are impaired in familial hemophagocytic lymphohistiocytosis type 4 (FHL-4), a disorder caused by mutations in the gene encoding the SNARE protein syntaxin 11.
Andrew L Hellewell +4 more
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Syntaxin 3 is haplosufficient for long-term photoreceptor survival in the mouse retina
Frontiers in Ophthalmology, 2023 Biallelic loss-of-function mutations in the syntaxin 3 gene have been linked to a severe retinal dystrophy in humans that presents in early childhood. In mouse models, biallelic inactivation of the syntaxin 3 gene in photoreceptors rapidly leads to their
Mariajose Perez-Hurtado +4 more
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Exploring the Two Coupled Conformational Changes That Activate the Munc18-1/Syntaxin-1 Complex
Frontiers in Molecular Neuroscience, 2021 Calcium-dependent synaptic vesicle exocytosis is mediated by SNARE complex formation. The transition from the Munc18-1/syntaxin-1 complex to the SNARE complex is catalyzed by the Munc13-1 MUN domain and involves at least two conformational changes ...
Jihong Gong +6 more
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