Results 91 to 100 of about 248,478 (203)

Chronic silencing of subsets of cortical layer 5 pyramidal neurons has a long‐term influence on the laminar distribution of parvalbumin interneurons and the perineuronal nets

Journal of Anatomy, Volume 246, Issue 4, Page 479-504, April 2025.
Chronic silencing of subsets of layer 5 projection neurons has distinct effects on the laminar distribution of PV interneurons and the perineuronal nets in the adult primary motor and somatosensory cortex. Abstract Neural networks are established throughout cortical development, which require the right ratios of glutamatergic and GABAergic neurons ...
Florina P. Szabó, Veronika Sigutova, Anna M. Schneider, Anna Hoerder‐Suabedissen, Zoltán Molnár   +4 more
wiley   +1 more source

Syntaxin 1A gene polymorphism in multiple sclerosis: a case–control study

The Egyptian Journal of Neurology, Psychiatry and Neurosurgery
Background Syntaxin 1A is a member of a membrane-integrated nervous system-specific protein superfamily involved in the neuromediator release from synaptic vesicles and one of the proteins included in axonal integrity.
Mohammed I. Oraby, Rasha H. Soliman, Noha A. Abdel Kader, Esraa M. Abdul Galil, Mohammed M. Masoud   +4 more
doaj   +1 more source

Dynamical Organization of Syntaxin-1A at the Presynaptic Active Zone.

PLoS Computational Biology, 2015
Synaptic vesicle fusion is mediated by SNARE proteins forming in between synaptic vesicle (v-SNARE) and plasma membrane (t-SNARE), one of which is Syntaxin-1A.
Alexander Ullrich, Mathias A Böhme, Johannes Schöneberg, Harald Depner, Stephan J Sigrist, Frank Noé   +5 more
doaj   +1 more source

Characterization of SNARE Cleavage Products Generated by Formulated Botulinum Neurotoxin Type-A Drug Products

Toxins, 2010
The study evaluated substrate cleavage product(s) generated by three botulinum neurotoxin serotype A (BoNT/A) medicinal drug products utilizing a novel and highly specific, light-chain activity, high-performance liquid chromatography (LCA-HPLC) method ...
Jack Xie, Julia Weidler, Terrence Hunt, David Rupp, Gary Shimizu, Karen Tam   +5 more
doaj   +1 more source

The Weibel-Palade Body Localized SNARE (Soluble NSF Attachment Protein Receptor) Syntaxin-3 Modulates Von Willebrand Factor Secretion From Endothelial Cells [PDF]

, 2018
Objective Endothelial cells store von Willebrand factor (VWF) in rod-shaped secretory organelles, called Weibel-Palade bodies (WPBs). WPB exocytosis is coordinated by a complex network of Rab GTPases, Rab-effectors and SNARE proteins. We have previously
Adam, R, Bierings, R, Carter, TD, Escher, JC, Gangaev, A, Hofman, M, Janssen, H, Jost, CR, Karampini, E, Koster, AJ, Meems, H, Mulder, AA, Schillemans, M, van Breevoort, D, van den Biggelaar, M, van den Eshof, B, Voorberg, J   +16 more
core   +2 more sources

Defender or accomplice? Dual roles of plant vesicle trafficking in restricting and enabling geminiviral systemic infection

New Phytologist, EarlyView.
Summary The vesicle trafficking system enables multidirectional cargo fluxes between endomembrane compartments. However, vesicle trafficking plays dual roles during pathogen infections. In plants, it mediates autophagic immune responses but can also be hijacked by pathogens to facilitate successful infections.
Pepe Cana‐Quijada, Pablo Morales‐Martínez, Tábata Rosas‐Díaz, Jessica Pérez‐Sancho, Tamara Jiménez‐Góngora, José Antonio Navarro, Rosa Lozano‐Durán, Araceli G. Castillo, Vicente Pallás, Eduardo R. Bejarano   +9 more
wiley   +1 more source

SNARE Complexity in Arbuscular Mycorrhizal Symbiosis

Frontiers in Plant Science, 2020
How cells control the proper delivery of vesicles and their associated cargo to specific plasma membrane (PM) domains upon internal or external cues is a major question in plant cell biology. A widely held hypothesis is that expansion of plant exocytotic
Rik Huisman, Jan Hontelez, Ton Bisseling, Erik Limpens   +3 more
doaj   +1 more source

Monoubiquitination of syntaxin 3 leads to retrieval from the basolateral plasma membrane and facilitates cargo recruitment to exosomes [PDF]

, 2017
Syntaxin 3 (Stx3), a SNARE protein located and functioning at the apical plasma membrane of epithelial cells, is required for epithelial polarity.
Adrian J. Giovannone, Alberto Fraile-Ramos, Alenquer M, Barbieri MA, Bezprozvanny I, Bilodeau PS, Breuza L, Britt WJ, Calistri A, Campeau E, Castle AM, Cepeda V, Cepeda V, Chin LS, Clague MJ, Danielsen JM, Delgrossi MH, Dragovic RA, Elena Reales, Fowler KB, Fraile-Ramos A, Fraile-Ramos A, Fujita H, Geng L, Gong Q, Gonzales PA, Guo X, Guo Z, Hackam DJ, Henne WM, Hibi T, Hicke L, Hislop JN, Hong W, Huang F, Huang S, Hurley JH, Jahn R, Kamsteeg EJ, Keith E. Mostov, Kim W, Kwon SH, Kyuuma M, Lakkaraju A, Leung YM, Li X, Liu ST, Low SH, Marchese A, McCullough J, McSharry BP, Meckes DG, Moffat J, Mori Y, Na CH, Naldini L, Naren AP, Olkkonen VM, Ostrowski M, Pallavi Bhattaram, Pawliczek T, Raiborg C, Raiborg C, Ren J, Riento K, Rodriguez-Boulan E, Rothman JE, Sharma N, Shields SB, Shih SC, Simons M, Singer-Lahat D, Somsel Rodman J, Stringer DK, Sudhof TC, Tandon R, ter Beest MB, Thery C, Thomas Weimbs, van Niel G, Weimbs T, Weimbs T, Weimbs T, Wickner W, Wojcikiewicz RJ, Yatsu A, Zerial M   +86 more
core   +3 more sources

Symbiosis‐associated UMAMIT transporters required for establishing efficient nitrogen fixation in Medicago truncatula

New Phytologist, EarlyView.
Summary To address a critical gap in understanding amino acid transport in legume–Rhizobium symbiosis, we investigated the role of symbiosis‐associated USUALLY MULTIPLE ACIDS MOVE IN AND OUT TRANSPORTERS (UMAMITs) in Medicago truncatula nodulation.
Courtney S. Winning, María Isabel Rubia, Wei Liu, Daniel Bronitt, Ángel María Zamarreño, José María García‐Mina, Penelope Smith, Estíbaliz Larrainzar, Michael A. Djordjevic   +8 more
wiley   +1 more source

Syntaxin 18 regulates the DNA damage response and epithelial-to-mesenchymal transition to promote radiation resistance of lung cancer

Cell Death and Disease, 2022
Radiotherapy is an important modality in lung cancer treatment. Despite advances in treatment planning and dose delivery, patient benefit is still limited by in-field relapse and metastatic recurrence.
Clotilde Thumser-Henner, Sebastian Oeck, Sophie Kalmbach, Jan Forster, Franziska Kindl, Ali Sak, Alexander Schramm, Martin Schuler   +7 more
doaj   +1 more source