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Syntaxin 11: A Member of the Syntaxin Family without a Carboxyl Terminal Transmembrane Domain
Biochemical and Biophysical Research Communications, 1998We have cloned a novel syntaxin-like molecule, designated human syntaxin 11 (hsyn11). The open reading frame encodes a polypeptide of 287 amino acids with potential coiled-coil domains. hsyn11 has extensive homology to members of the syntaxin family, particularly syntaxin 1 and syntaxin 2.
B L, Tang, D Y, Low, W, Hong
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Traffic, 2010
Membrane fusion is dependent on the function of SNAREs and their alpha-helical SNARE motifs that form SNARE complexes. The Habc domains at the N-termini of some SNAREs can interact with their associated SNARE motif, Sec1/Munc18 (SM) proteins, tethering proteins or adaptor proteins, suggesting that they play an important regulatory function. We screened
Grant P, Otto +4 more
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Membrane fusion is dependent on the function of SNAREs and their alpha-helical SNARE motifs that form SNARE complexes. The Habc domains at the N-termini of some SNAREs can interact with their associated SNARE motif, Sec1/Munc18 (SM) proteins, tethering proteins or adaptor proteins, suggesting that they play an important regulatory function. We screened
Grant P, Otto +4 more
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Interaction of syntaxins with epithelial ion channels
Current Opinion in Nephrology and Hypertension, 2000Recent evidence suggests that some of the syntaxin isoforms may physically interact with and regulate the transport activity of a defined set of membrane transport proteins. This review examines recent studies of the cystic fibrosis transmembrane conductance regulator and the epithelial sodium channel which define distinct roles of syntaxin 1A and ...
S, Saxena, M W, Quick, D G, Warnock
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Transmembrane Organization of Yeast Syntaxin-Analogue Sso1p
Biochemistry, 2006Membrane fusion in secretory pathways is thought to be mediated by SNAREs. It is proposed that membrane fusion transits through hemifusion, a condition in which the outer leaflets of the bilayers are mixed, but the inner leaflets are not. Hemifusion then proceeds to the fusion pore that connects the two internal contents.
Yinghui, Zhang, Yeon-Kyun, Shin
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The syntaxin family of vesicular transport receptors
Cell, 1993Syntaxins A and B are nervous system-specific proteins implicated in the docking of synaptic vesicles with the presynaptic plasma membrane. A family of syntaxin-related proteins from rat has been identified that shares 23%-84% amino acid identity. Each of the six syntaxins terminate with a carboxy-terminal hydrophobic domain that anchors the protein on
M K, Bennett +6 more
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Regulation of Syntaxin 17 during Autophagosome Maturation
Trends in Cell Biology, 2019During macroautophagy, cytosolic elements are confined in autophagosomes before fusion with endolysosomes for degradation or recycling. Recruitment of the SNARE (soluble N-ethylmaleimide-sensitive factor attachment protein receptor) factor syntaxin 17 (STX17) is instrumental for this maturation step. Two recent studies indicate that the kinase ULK1 and
Viret, Christophe, Faure, Mathias
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Endocytotic Function for Syntaxin 1A
Science's STKE, 2006Syntaxin 1A is a plasma membrane protein of the SNARE (soluble N -ethylmaleimide-sensitive factor attachment protein receptor) family, well known for its essential roles in neuronal signaling in which it regulates trafficking, docking, and fusion of synaptic vesicles with the plasma membrane. Experiments from Yu
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