Results 21 to 30 of about 248,478 (203)
An N-terminal missense mutation in STX11 causative of FHL4 abrogates syntaxin-11 binding to Munc18-2
Frontiers in Immunology, 2014 Familial hemophagocytic lymphohistiocytosis (FHL) is an often-fatal hyperinflammatory disorder caused by autosomal recessive mutations in PRF1, UNC13D, STX11, and STXBP2.
Martha-Lena eMuller +13 more
doaj +1 more source
Tetraspanin-8 sequesters syntaxin-2 to control biphasic release propensity of mucin granules
Nature Communications, 2023 Agonist-mediated stimulated pathway of mucin and insulin release are biphasic in which rapid fusion of pre-docked granules is followed by slow docking and fusion of granules from the reserve pool. Here, based on a cell-culture system, we show that plasma
José Wojnacki +7 more
doaj +1 more source
Syntaxin 1C, a soluble form of syntaxin, attenuates membrane recycling by destabilizing microtubules [PDF]
Journal of Cell Science, 2012 Syntaxin 1C (STX1C), produced by alternative splicing of the stx1A gene, is a soluble syntaxin lacking a SNARE domain and a transmembrane domain. It is unclear how soluble syntaxin can control intracellular membrane trafficking. We found that STX1C affected microtubule (MT) dynamics through its tubulin-binding domain (TBD) and regulated recycling of ...
Takahiro, Nakayama +2 more
openaire +2 more sources
Syntaxin 3b is a t-SNARE specific for ribbon synapses of the retina. [PDF]
, 2008 Previous studies have demonstrated that ribbon synapses in the retina do not contain the t-SNARE (target-soluble N-ethylmaleimide-sensitive factor attachment protein receptor) syntaxin 1A that is found in conventional synapses of the nervous system.
Curtis, Leigh B +5 more
core +1 more source
Protein structure and phenotypic analysis of pathogenic and population missense variants in STXBP1 [PDF]
, 2017 Background: Syntaxin-binding protein 1, encoded by STXBP1, is highly expressed in the brain and involved in fusing synaptic vesicles with the plasma membrane.
Baker, K +17 more
core +2 more sources
Plant Signaling & Behavior, 2022 Plant innate immunity toward cell-wall penetrating filamentous pathogens relies on the conserved SYP12 clade of secretory syntaxins. In Arabidopsis, the two closely related SYP12 clade members, PEN1 and SYP122, play an overlapping role in this general ...
Mengqi Liu +2 more
doaj +1 more source
Synaptic proteins promote calcium-triggered fast transition from point contact to full fusion. [PDF]
, 2012 The molecular underpinnings of synaptic vesicle fusion for fast neurotransmitter release are still unclear. Here, we used a single vesicle-vesicle system with reconstituted SNARE and synaptotagmin-1 proteoliposomes to decipher the temporal sequence of ...
Brunger, Axel T +13 more
core +1 more source
Localization of plasma membrane t-SNAREs syntaxin 2 and 3 in intracellular compartments
BMC Cell Biology, 2005 Background Membrane fusion requires the formation of a complex between a vesicle protein (v-SNARE) and the target membrane proteins (t-SNAREs). Syntaxin 2 and 3 are t-SNAREs that, according to previous over-expression studies, are predominantly localized
Kuismanen Esa, Band Arja M
doaj +1 more source
Frontiers in Endocrinology, 2023 The fusion of the secretory vesicle with the plasma membrane requires the assembly of soluble N-ethylmaleimide-sensitive factor attachment protein receptor (SNARE) protein complexes formed by synaptobrevin, syntaxin-1, and SNAP-25.
Xinquan Yang +5 more
doaj +1 more source
Molecular Aspects of Secretory Granule Exocytosis by Neurons and Endocrine Cells [PDF]
, 1994 Neuronal communication and endocrine signaling are fundamental for integrating the function of tissues and cells in the body. Hormones released by endocrine cells are transported to the target cells through the circulation.
Ahnert-Hilger G. +28 more
core +1 more source