Results 31 to 40 of about 248,478 (203)
Syntaxin Clustering in Membranes [PDF]
Biophysical Journal, 2010 Syntaxin-1A and SNAP25 form the receptor component of the SNARE complex, which has been shown to be the minimal machinery for membrane fusion. In vivo studies have revealed that syntaxin-1A exists in cholesterol-dependent clusters that are distinct from lipid rafts.
Murray, David H., Tamm, Lukas K.
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Munc18-bound syntaxin readily forms SNARE complexes with synaptobrevin in native plasma membranes.
PLoS Biology, 2006 Munc18-1, a protein essential for regulated exocytosis in neurons and neuroendocrine cells, belongs to the family of Sec1/Munc18-like (SM) proteins. In vitro, Munc18-1 forms a tight complex with the SNARE syntaxin 1, in which syntaxin is stabilized in a ...
Felipe E Zilly +3 more
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Frontiers in Molecular Neuroscience, 2016 Syntaxins are a family of membrane-integrated proteins that are instrumental in exocytosis of vesicles. Syntaxin-1 is an essential component of the presynaptic exocytotic fusion machinery in the brain and interacts with several other proteins. Syntaxin-1
Suleman eHussain +4 more
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Regulation of Syntaxin3B-Mediated Membrane Fusion by T14, Munc18, and Complexin
Biomolecules, 2023 Retinal neurons that form ribbon-style synapses operate over a wide dynamic range, continuously relaying visual information to their downstream targets.
Rajkishor Nishad +4 more
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Early stages of retinal development depend on Sec13 function [PDF]
, 2013 Summary ER-to-Golgi transport of proteins destined for the extracellular space or intracellular compartments depends on the COPII vesicle coat and is constitutive in all translationally active cells.
Cavodeassi, Florencia +3 more
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Differential Roles of Syntaxin 7 and Syntaxin 8 in Endosomal Trafficking
Molecular Biology of the Cell, 1999 To understand molecular mechanisms that regulate the intricate and dynamic organization of the endosomal compartment, it is important to establish the morphology, molecular composition, and functions of the different organelles involved in endosomal trafficking.
Prekeris, R. +4 more
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Syntaxin 1A Regulates ENaC Channel Activity [PDF]
Journal of Biological Chemistry, 2004 Na(+) entry across the apical membranes of many absorptive epithelia is determined by the number (N) and open probability (P(o)) of epithelial sodium channels (ENaC). Previous results showed that the H3 domain of syntaxin-1A (S1A) binds to ENaC to reduce N, supporting a role for S1A in the regulation of ENaC trafficking.
Steven B, Condliffe +2 more
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Munc18-1 induces conformational changes of syntaxin-1 in multiple intermediates for SNARE assembly
Scientific Reports, 2020 In neuronal exocytosis, SNARE assembly into a stable four-helix bundle drives membrane fusion. Previous studies have revealed that the SM protein Munc18-1 plays a critical role for precise SNARE assembly with the help of Munc13-1, but the underlying ...
Sanghwa Lee +7 more
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The involvement of actin, calcium channels and exocytosis proteins in somato-dendritic oxytocin and vasopressin release [PDF]
, 2012 Hypothalamic magnocellular neurons release vasopressin and oxytocin not only from their axon terminals into the blood, but also from their somata and dendrites into the extracellular space of the brain, and this can be regulated independently ...
Leng, Gareth, Ludwig, Mike, Tobin, Vicky
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Lipid raft microdomain compartmentalization of TC10 is required for insulin signaling and GLUT4 translocation. [PDF]
, 2001 Recent studies indicate that insulin stimulation of glucose transporter (GLUT)4 translocation requires at least two distinct insulin receptor-mediated signals: one leading to the activation of phosphatidylinositol 3 (PI-3) kinase and the other to the ...
Chiang, SH +7 more
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