How Tlg2p/syntaxin 16 'snares' Vps45 [PDF]
The EMBO Journal, 2002 Soluble N-ethylmaleimide sensitive factor-attachment protein receptors (SNAREs) and Sec1p/Munc18-homologs (SM proteins) play key roles in intracellular membrane fusion. The SNAREs form tight four-helix bundles (core complexes) that bring the membranes together, but it is unclear how this activity is coupled to SM protein function.
Irina, Dulubova +6 more
openaire +2 more sources
The eukaryotic signal sequence, YGRL, targets the chlamydial inclusion
Frontiers in Cellular and Infection Microbiology, 2014 Understanding how host proteins are targeted to pathogen-specified organelles, like the chlamydial inclusion, is fundamentally important to understanding the biogenesis of these unique subcellular compartments and how they maintain autonomy within the ...
Emily M Kabeiseman +2 more
doaj +1 more source
The impact of phenotype, ethnicity and genotype on progression of Type 2 diabetes mellitus [PDF]
, 2020 Aim: To conduct a comprehensive review of studies of glycaemic deterioration in type 2 diabetes and identify the major factors influencing progression.Methods: We conducted a systematic literature search with terms linked to type 2 diabetes progression ...
Anjana, Ranjit M. +7 more
core +2 more sources
Identification of residues critical for the extension of Munc18-1 domain 3a
BMC Biology, 2023 Background Neurotransmitter release depends on the fusion of synaptic vesicles with the presynaptic membrane and is mainly mediated by SNARE complex assembly.
Xianping Wang +8 more
doaj +1 more source
Cleaved intracellular SNARE peptides are implicated in a novel cytotoxicity mechanism of botulinum serotype C [PDF]
, 2013 Recent advances in intracellular protein delivery have enabled more in-depth analyses of cellular functions. A specialized family of SNARE proteases, known as Botulinum Neurotoxins, blocks neurotransmitter exocytosis, which leads to systemic toxicity ...
Arsenault, Jason +5 more
core +1 more source
Journal of Neurochemistry, 2014 AbstractTwo types of syntaxin 1 isoforms, HPC‐1/syntaxin 1A (STX1A) and syntaxin 1B (STX1B), are thought to have similar functions in exocytosis of synaptic vesicles. STX1A−/− mice which we generated previously develop normally, possibly because of compensation by STX1B.
Takefumi, Kofuji +4 more
openaire +2 more sources
Localization of SNAP-29 and Syntaxin 6 in the brain of Bombyx mori
European Journal of EntomologySoluble N-ethylmaleimide-sensitive factor attachment protein receptors (SNAREs) are a family of small conserved eukaryotic proteins that mediate fusion between organelles and the plasma membrane.
Fumika TORYU +5 more
doaj +1 more source
Direct interaction of endogenous Kv channels with syntaxin enhances exocytosis by neuroendocrine cells. [PDF]
PLoS ONE, 2008 K(+) efflux through voltage-gated K(+) (Kv) channels can attenuate the release of neurotransmitters, neuropeptides and hormones by hyperpolarizing the membrane potential and attenuating Ca(2+) influx.
Dafna Singer-Lahat +2 more
doaj +1 more source
Genetic disorders of neurotransmitter release machinery
Frontiers in Synaptic Neuroscience, 2023 Synaptic neurotransmitter release is an evolutionarily conserved process that mediates rapid information transfer between neurons as well as several peripheral tissues.
Burak Uzay +3 more
doaj +1 more source
Current status and future directions of botulinum neurotoxins for targeting pain processing. [PDF]
, 2015 Current evidence suggests that botulinum neurotoxins (BoNTs) A1 and B1, given locally into peripheral tissues such as skin, muscles, and joints, alter nociceptive processing otherwise initiated by inflammation or nerve injury in animal models and humans.
Pellett, Sabine +2 more
core +2 more sources