Results 71 to 80 of about 248,478 (203)
Biotechnology and Applied Biochemistry, EarlyView.ABSTRACT Gastrointestinal cancers (GICs) constitute one of the leading causes of cancer‐related morbidity and mortality worldwide. Despite currently available therapeutic strategies, new approaches and procedures are needed for their prevention and treatment.
Raúl Vergara +5 more
wiley +1 more source
Heterologous Expression of Syntaxin 6 in Saccharomyces cerevisiae
Biological Research, 2002 The molecular mechanisms of vesicular protein transport in eukaryotic cells are highly conserved. Members of the syntaxin family play a pivotal role in the membrane fusion process.
MARTIN GÖTTE, ANDREA STADTBÄUMER
doaj
mTORC1 Is a Local, Postsynaptic Voltage Sensor Regulated by Positive and Negative Feedback Pathways
Frontiers in Cellular Neuroscience, 2017 The mammalian/mechanistic target of rapamycin complex 1 (mTORC1) serves as a regulator of mRNA translation. Recent studies suggest that mTORC1 may also serve as a local, voltage sensor in the postsynaptic region of neurons.
Farr Niere, Kimberly F. Raab-Graham
doaj +1 more source
Inhibition of activity of GABA transporter GAT1 by δ-opioid receptor [PDF]
, 2012 Analgesia is a well-documented effect of acupuncture. A critical role in pain sensation plays the nervous system, including the GABAergic system and opioid receptor (OR) activation.
Fucke, Thomas +7 more
core +2 more sources
BMEMat, EarlyView.Extracellular vesicles (EVs) derived from stem cells show promise for applications in regenerative medicine, but their scalability and yield remain challenges. This review explores the approaches for biophysical modulations within cell niches on EV properties, discusses the current clinical application of EVs, and provides an outlook on the existing ...
Yang Xu +9 more
wiley +1 more source
Localization of synaptotagmin-binding domains on syntaxin [PDF]
The Journal of Neuroscience, 1996 Synaptotagmin, an abundant calcium- and phospholipid-binding protein of synaptic vesicles, has been proposed to regulate neurotransmitter release at the nerve terminal. To understand better the biochemical mechanism of neurotransmitter release, we have investigated the calcium- dependent and -independent protein-protein interactions between ...
Y, Kee, R H, Scheller
openaire +2 more sources
Regulatory mechanisms of reproduction in locusts and grasshoppers
New Plant Protection, EarlyView.Regulatory networks composed of numerous coding and noncoding genes play crucial roles in the reproduction of locusts and grasshoppers. This review integrates mechanistic advances in reproductive regulation, highlighting environmentally adaptive pathways and providing prospective targets for eco‐friendly pesticides.
Jing He, Jiliang Wang, Xinran Wang
wiley +1 more source
Nel positively regulates the genesis of retinal ganglion cells by promoting their differentiation and survival during development [PDF]
, 2014 Peer reviewedPublisher ...
Adams JC +67 more
core +1 more source
Syntaxin 7 modulates seizure activity in epilepsy
Neurobiology of Disease, 2023 The exact pathogenesis of epilepsy, one of the most common and devastating diseases of the nervous system, is not fully understood. Syntaxin7 (STX7) is a member of the SNARE superfamily, which mediates membrane fusion events in all cells. However, the role STX7 plays in epilepsy remains unclear.
Junhong Wu +9 more
openaire +3 more sources
Proteome Analysis of Corynebacterium diphtheriae–Macrophage Interaction
PROTEOMICS, EarlyView.ABSTRACT Contact of Corynebacterium diphtheriae with macrophages induces adaptations on both bacterial and cellular sides. The study presented here was aiming to shed light on the simultaneous intracellular adaptation of the bacteria and changes in the proteome of the phagocytes in response to the internalization of C. diphtheriae.
Luca Musella +6 more
wiley +1 more source