Results 291 to 300 of about 12,982,812 (373)

C2α‐carbanion‐protonating glutamate discloses tradeoffs between substrate accommodation and reaction rate in actinobacterial 2‐hydroxyacyl‐CoA lyase

FEBS Open Bio, EarlyView.
Enzymes of the 2‐hydroxyacyl‐CoA lyase group catalyze the condensation of formyl‐CoA with aldehydes or ketones. Thus, by structural adaptation of active sites, practically any pharmaceutically and industrially important 2‐hydroxyacid could be biotechnologically synthesized. Combining crystal structure analysis, active site mutations and kinetic assays,
Michael Zahn, Barbara Seroka, Ryszard Lazny, Zenon Lotowski, Thore Rohwerder   +4 more
wiley   +1 more source

Recent advancements in the synthesis of <i>Veratrum</i> alkaloids. [PDF]

Beilstein J Org Chem
Mögel M, Berger D, Heretsch P.
europepmc   +1 more source

Enhancing Oncological Care for India's Aging Population: Addressing the Complex Needs of Older Adults With Cancer

Aging and Cancer, EarlyView.
Aging‐associated physiological and molecular alterations pose significant challenges in cancer management among India's elderly. Limited geriatric oncology expertise, financial constraints, and inadequate specialized care exacerbate disparities. Strategic expansion of insurance coverage, integration of palliative care, and infrastructural advancements ...
Nihanthy D. Sreenath, Mathigatta Shivarudraiah S, Rajath Govind, Kaushik M R   +3 more
wiley   +1 more source

DDQ-promoted synthesis of 2-benzoylbenzofurans and benzofuro[2,3-<i>c</i>]pyridines using 2'-hydroxy ethyl cinnamate and phenacyl bromides. [PDF]

RSC Adv
Saini SM, Singh HR, Katiyar R, Chandrashekharappa S.   +3 more
europepmc   +1 more source

Cutaneous Melanoma Drives Metabolic Changes in the Aged Bone Marrow Immune Microenvironment

Aging and Cancer, EarlyView.
Melanoma, the deadliest form of skin cancer, increasingly affects older adults. Our study reveals that melanoma induces changes in iron and lipid levels in the bone marrow, impacting immune cell populations and increasing susceptibility to ferroptosis.
Alexis E. Carey, Murilo Ramos Rocha, Cheyenne Palm, Vania Wang, Denys Balandin, Ethan Black, Kevin Y. Zhang, Fan Huang, Daniel J. Zabransky, Yash Chhabra, Mareike Peters, Gabriel Ghiaur, Ashani Weeraratna   +12 more
wiley   +1 more source

General Movements Assessment and Amiel-Tison Neurologic Examination in Neonates and Infants: Correlations and Prognostic Values Regarding Neuromotor Outcomes. [PDF]

Life (Basel)
Toma AI, Dima V, Rusu L, Necula A, Stoiciu RP, Andrășoaie L, Mirea A, Bivoleanu AR.   +7 more
europepmc   +1 more source

A General Synthesis Method for Covalent Organic Framework and Inorganic 2D Materials Hybrids

Yifan Zhu, Yunrui Yan, Yuren Feng, Yifeng Liu, Chen-yang Lin, Qing Ai, Tianshu Zhai, Bongki Shin, Rui Xu, Hongchen Shen, Qiyi Fang, Xiang Zhang, Dayanni D. Bhagwandin, Yimo Han, Hanyu Zhu, Nicholas R. Glavin, Pulickel M. Ajayan, Qilin Li, Jun Lou   +18 more
openalex   +1 more source

Natural Products as Geroprotective Modulators in Diabetic Nephropathy: A Mechanistic Framework Integrating Aging Hallmarks and the AMPK–SIRT1–Nrf2 Axis

Aging and Cancer, EarlyView.
Natural products target the aging kidney in diabetic nephropathy by restoring the AMPK–SIRT1–Nrf2 axis, reducing oxidative stress, inflammation, fibrosis, and cellular senescence while enhancing mitochondrial biogenesis and antioxidant defenses.
Sherif Hamidu, Latif Adams, Eunice Ampem‐Danso, Justice Kumi, Abigail Aning, Fatima Hamidu, Mustapha Abdul Mumin Mohammed, Ayuba Nii Darku Ankrah, Seth Kwabena Amponsah   +8 more
wiley   +1 more source