Results 51 to 60 of about 5,131,645 (316)
Organoids in pediatric cancer research
FEBS Letters, EarlyView.Organoid technology has revolutionized cancer research, yet its application in pediatric oncology remains limited. Recent advances have enabled the development of pediatric tumor organoids, offering new insights into disease biology, treatment response, and interactions with the tumor microenvironment.
Carla Ríos Arceo, Jarno Drost
wiley +1 more source
, 2017 A welcome from the editors and a summary of the first issue of Synthesis: A Digital Journal of Student Science ...
Shetty, Brinda +2 more
core +1 more source
FEBS Letters, EarlyView.Structural and biochemical characterisations show that the planar cell polarity (PCP) protein Inturned harbours a unique PDZ‐like domain that does not bind canonical PDZ‐binding motifs (PBMs) like that of another PCP protein Vangl2. In contrast, the apical‐basal polarity protein Scribble contains four PDZ domains that bind Vangl2, but one PDZ domain ...
Stephan Wilmes +4 more
wiley +1 more source
Synthesis of the C1-C12 Fragment of Calyculin C
, 2019 Calyculins are a class of highly cytotoxic metabolites originally isolated from the marine sponge Discodermia calyx. To date, a total of twelve different calyculins (A-J) and calyculinamides (A, B and F) have been described, the most abundant (in D ...
Konstantinova, Olga V. +1 more
core +1 more source
Structural insights into an engineered feruloyl esterase with improved MHET degrading properties
FEBS Letters, EarlyView.A feruloyl esterase was engineered to mimic key features of MHETase, enhancing the degradation of PET oligomers. Structural and computational analysis reveal how a point mutation stabilizes the active site and reshapes the binding cleft, expading substrate scope.
Panagiota Karampa +5 more
wiley +1 more source
Studies toward the total synthesis of (±)-chartelline C and (-)-platensimycin [PDF]
, 2008 textHerein is described our work towards the total synthesis of the marine natural product (±)-chartelline C and the potent antibiotic (-)-platensimycin. Part 1 relates the (±)-chartelline C project.
Hecker, Evan Adam, 1980-
core
The synthesis of antibiotics and amino acids [PDF]
, 1989 This thesis is divided into two parts: Part One describes synthetic approaches to the naturally occurring antibiotic Lactivicin (1) and its acylamino derivatives, involving the condensation of protected L-cycloserine with 2 ...
Lowe, Christopher, Lowe, Christopher.
core +1 more source
A robotic platform for the synthesis of colloidal nanocrystals
, 2023 Morphological control with broad tunability is a primary goal for the synthesis of colloidal nanocrystals with unique physicochemical properties. Here we develop a robotic platform as a substitute for trial-and-error synthesis and labour-intensive ...
Baicheng Zhang +33 more
core +1 more source
Gut microbiome and aging—A dynamic interplay of microbes, metabolites, and the immune system
FEBS Letters, EarlyView.Age‐dependent shifts in microbial communities engender shifts in microbial metabolite profiles. These in turn drive shifts in barrier surface permeability of the gut and brain and induce immune activation. When paired with preexisting age‐related chronic inflammation this increases the risk of neuroinflammation and neurodegenerative diseases.
Aaron Mehl, Eran Blacher
wiley +1 more source
Recent advances in the total synthesis of prenylflavonoid and related diels-alder natural products
, 2015 This review summarizes the application of different strategies for the key Diels-Alder cycloaddition in prenylflavonoid and related Diels-Alder natural products synthesis, highlighting the application of novel methodologies and innovative strategies in ...
Lei, Xiaoguang +2 more
core +1 more source