Results 31 to 40 of about 368,128 (266)
Optimum Path Synthesis of a Geared Five-Bar Mechanism
Advances in Mechanical Engineering, 2013 Most studies on path synthesis problems are to trace simple or smooth trajectories. In this work, an optimum synthesis for several special trajectories generated by a geared five-bar mechanism is studied using the one-phase synthesis method.
Wen-Yi Lin
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RUDN Journal of Engineering Research, 2021 The spatial stabilization system synthesis problem of the robot is considered. The historical overview of methods and approaches for solving the problem of control synthesis is given.
Askhat I. Diveev +1 more
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Transforming Undecidable Synthesis Problems into Decidable Problems
EPiC Series in Computing, 2018 Synthesis holds the promise to revolutionize the development ofcomplex systems by automating the translation from specifications toimplementations. Synthesis algorithms are based on the same level ofmathematical rigor as verification algorithms but can be applied atearlier development stages, when only parts of the design areavailable.
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Finding novel vulnerabilities of hypomorphic BRCA1 alleles
Molecular Oncology, EarlyView.Synthetic lethality screens performed to identify novel vulnerabilities often model complete gene loss, thereby overlooking patient‐derived hypomorphic mutations. In this study, we have performed genome‐wide CRISPR screens on BRCA1 hypomorphic mutations, showing BRCA1I26A behaves like wild‐type, while BRCA1R1699Q mimics deficiency. Furthermore, we have
Anne Schreuder +10 more
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The Access Pricing Problem: A Synthesis
The Journal of Industrial Economics, 1996 The Baumol-Willig efficient component pricing rule states that it is efficient to set the price of access to an essential facility equal to the direct cost of access plus the opportunity cost to the integrated access provider. The authors analyze the relevant notion of 'opportunity cost' under various assumptions about demand and supply conditions ...
Armstrong, M., Doyle, C., Vickers, J.
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Molecular Oncology, EarlyView.Single‐cell DNA methylation (scDNAme) profiling maps epimutational clonal evolution, revealing mechanisms of malignancy and therapeutic resistance across diverse cancer types. By providing a high‐resolution landscape of intratumoral heterogeneity, these technologies empower precise patient stratification, guide the development of enhanced ...
Ik Soo Kim
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Optimum shape synthesis of path generating mechanisms using wavelet descriptors
Journal of Advanced Mechanical Design, Systems, and Manufacturing, 2019 The discrete wavelet transform is a well-known mathematical tool for shape recognition. In this study, a wavelet descriptor with two shape signatures, i.e., centroid distance and triangular centroid area, is developed for shape synthesis for path ...
Wen-Yi LIN
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A High-Level LTL Synthesis Format: TLSF v1.1 [PDF]
Electronic Proceedings in Theoretical Computer Science, 2016 We present the Temporal Logic Synthesis Format (TLSF), a high-level format to describe synthesis problems via Linear Temporal Logic (LTL). The format builds upon standard LTL, but additionally allows to use high-level constructs, such as sets and ...
Swen Jacobs +2 more
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Applied Sciences, 2022 The optimal methods for the synthesis of mechanisms in rehabilitation usually require solving constrained optimization problems. Metaheuristic algorithms are frequently used to solve these problems with the inclusion of Constraint-Handling Techniques ...
José Saúl Muñoz-Reina +3 more
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ADP‐ribosylation: An emerging regulator of the epigenome
Molecular Oncology, EarlyView.ADP‐ribosylation has emerged as a dynamic epigenetic signaling mechanism that modifies histones and chromatin‐associated proteins. Through coordinated PARylation and MARylation, it integrates with other histone modifications to regulate chromatin structure, transcription factor activity, and gene expression, influencing genome function and disease ...
Cristel V. Camacho +2 more
wiley +1 more source