Results 61 to 70 of about 16,212,430 (313)

Benefits of Using a Problem-Solving Scaffold for Teaching and Learning Synthesis in Undergraduate Organic Chemistry I

International Journal for the Scholarship of Teaching and Learning, 2016
A problem-solving scaffold approach to synthesis was developed and implemented in two intervention sections of Chemistry 2211K (Organic Chemistry I) at Georgia Gwinnett College (GGC).
Joseph Sloop, Mai Yin Tsoi, Patrick Coppock   +2 more
doaj   +1 more source

Process Synthesis and Design Problems Based on a Global Particle Swarm Optimization Algorithm

IEEE Access, 2021
Many process synthesis and design problems in engineering are actually mixed integer nonlinear programming problems (MINLP), because they contain both continuous and integer variables. These problems are generally recognized to be complex and intractable
Chuanhu Chen, Chunliang Li
doaj   +1 more source

CDK11 inhibition induces cytoplasmic p21WAF1 splice variant by p53 stabilisation and SF3B1 inactivation

Molecular Oncology, EarlyView.
CDK11 inhibition stabilises the tumour suppressor p53 and triggers the production of an alternative p21WAF1 splice variant p21L, through the inactivation of the spliceosomal protein SF3B1. Unlike the canonical p21WAF1 protein, p21L is localised in the cytoplasm and has reduced cell cycle‐blocking activity.
Radovan Krejcir, Lukasz Arcimowicz, Lucia Martinkova, Vaclav Hrabal, Filip Zavadil Kokas, Tomas Henek, Martina Kucerikova, Ondrej Bonczek, Pavlina Zatloukalova, Lenka Hernychova, Philip J. Coates, Borivoj Vojtesek, David P. Lane   +12 more
wiley   +1 more source

Optimum shape synthesis of path generating mechanisms using wavelet descriptors

Journal of Advanced Mechanical Design, Systems, and Manufacturing, 2019
The discrete wavelet transform is a well-known mathematical tool for shape recognition. In this study, a wavelet descriptor with two shape signatures, i.e., centroid distance and triangular centroid area, is developed for shape synthesis for path ...
Wen-Yi LIN
doaj   +1 more source

Transcriptional network analysis of PTEN‐protein‐deficient prostate tumors reveals robust stromal reprogramming and signs of senescent paracrine communication

Molecular Oncology, EarlyView.
Combining PTEN protein assessment and transcriptomic profiling of prostate tumors, we uncovered a network enriched in senescence and extracellular matrix (ECM) programs associated with PTEN loss and conserved in a mouse model. We show that PTEN‐deficient cells trigger paracrine remodeling of the surrounding stroma and this information could help ...
Ivana Rondon‐Lorefice, Jose I. Lopez, Aitziber Ugalde‐Olano, Maite Zufiaurre, Ianire Astobiza, Natalia Martin‐Martin, Laura Bozal‐Basterra, Saioa Garcia‐Longarte, Amaia Zabala‐Letona, Sofia Rey, Aida Santos‐Martin, Miguel Unda, Ana Loizaga‐Iriarte, Mariona Graupera, Paolo Nuciforo, Arkaitz Carracedo, Isabel Mendizabal   +16 more
wiley   +1 more source

Abstract Learning Frameworks for Synthesis

, 2016
We develop abstract learning frameworks (ALFs) for synthesis that embody the principles of CEGIS (counter-example based inductive synthesis) strategies that have become widely applicable in recent years. Our framework defines a general abstract framework
A Blum, A Cheung, A Lal, A Vardhan, Armando Solar-Lezama, C Flanagan, E Kitzelmann, E Kneuss, G Higman, M Barnett, MJ Kearns, P Garg, P Garg, P Černý, PM Domingos, R Sharma, S Saha, V Kuncak, Z Manna   +18 more
core   +1 more source

Developing evidence‐based, cost‐effective P4 cancer medicine for driving innovation in prevention, therapeutics, patient care and reducing healthcare inequalities

Molecular Oncology, EarlyView.
The cancer problem is increasing globally with projections up to the year 2050 showing unfavourable outcomes in terms of incidence and cancer‐related deaths. The main challenges are prevention, improved therapeutics resulting in increased cure rates and enhanced health‐related quality of life.
Ulrik Ringborg, Joachim von Braun, Julio Celis, Anton Berns, Michael Baumann, Tit Albreht, Nancy Abou‐Zeid, Vanderlei Bagnato, Christian Brandts, Chien‐Jen Chen, Massimiliano di Pietro, Manjit Dosanjh, Thomas Dubois, Alexander Eggermont, Angelika Eggert, Ingemar Ernberg, Sara Faithfull, Johannes Förner, Stefan Fröhling, Manuel Heitor, Leroy Hood, Wei Jiang, Bengt Jönsson, Ravi Kannan, Maria Leptin, Su Li, Peter Lindgren, Douglas Lowy, Jun Ma, Alex Markham, Péter Nagy, Simon Oberst, M. Iqbal Parker, Danielle Rodin, Kevin Ryan, Joachim Schüz, Richard Sullivan, Josep Tabernero, Peter Turkson, Oliver Várhelyi, Harold Varmus, Chijie Wang, Elisabete Weiderpass, Nils Wilking   +43 more
wiley   +1 more source

Rethinking plastic waste: innovations in enzymatic breakdown of oil‐based polyesters and bioplastics

FEBS Open Bio, EarlyView.
Plastic pollution remains a critical environmental challenge, and current mechanical and chemical recycling methods are insufficient to achieve a fully circular economy. This review highlights recent breakthroughs in the enzymatic depolymerization of both oil‐derived polyesters and bioplastics, including high‐throughput protein engineering, de novo ...
Elena Rosini, Nicolò Antonelli, Gianluca Molla   +2 more
wiley   +1 more source

Generative Adversarial Networks in Human Emotion Synthesis: A Review

IEEE Access, 2020
Deep generative models have become an emerging topic in various research areas like computer vision and signal processing. These models allow synthesizing realistic data samples that are of great value for both academic and industrial communities ...
Noushin Hajarolasvadi, Miguel Arjona Ramirez, Wesley Beccaro, Hasan Demirel   +3 more
doaj   +1 more source

Transforming Undecidable Synthesis Problems into Decidable Problems

EPiC Series in Computing, 2018
Synthesis holds the promise to revolutionize the development ofcomplex systems by automating the translation from specifications toimplementations. Synthesis algorithms are based on the same level ofmathematical rigor as verification algorithms but can be applied atearlier development stages, when only parts of the design areavailable.
openaire   +2 more sources