Results 81 to 90 of about 16,144,289 (353)

Organoids in pediatric cancer research

FEBS Letters, EarlyView.
Organoid technology has revolutionized cancer research, yet its application in pediatric oncology remains limited. Recent advances have enabled the development of pediatric tumor organoids, offering new insights into disease biology, treatment response, and interactions with the tumor microenvironment.
Carla Ríos Arceo, Jarno Drost
wiley   +1 more source

In-line Test of Synthesised Systems Exploiting Latency Analysis [PDF]

, 2000
During normal operation, there are periods of time in which units in a digital system (adders, multipliers etc.) are inactive, i.e. are not processing any useful data. These ?latent periods?
Williams, A.C., Brown, A.D., Zwolinski, M.   +2 more
core  

Design Considerations for Integrated Radar Chirp Synthesizers [PDF]

IEEE Access, 2019
Phase-locked loops (PLLs) effectively generate frequency chirps for frequency-modulated continuous-wave (FMCW) radar and are ideal for integrated circuit implementations. This paper discusses the design requirements for integrated PLLs used as chirp synthesizers for FMCW radar and focuses on an analysis of the radar performance based on the PLL ...
Daniel Weyer, Mehmet Batuhan Dayanik, Lu Jie 0001, Ahmed Albalawi, Abdulhamed Alothaimen, Mohammed Aseeri, Michael P. Flynn   +6 more
openaire   +2 more sources

Reciprocal control of viral infection and phosphoinositide dynamics

FEBS Letters, EarlyView.
Phosphoinositides, although scarce, regulate key cellular processes, including membrane dynamics and signaling. Viruses exploit these lipids to support their entry, replication, assembly, and egress. The central role of phosphoinositides in infection highlights phosphoinositide metabolism as a promising antiviral target.
Marie Déborah Bancilhon, Bruno Mesmin
wiley   +1 more source

Design in the world kitchen : a case study in multi-national collaborative design education [PDF]

, 2007
This case study describes an Industrial Design project concerning the kitchen, its environment and the products within it. The consuming and preparation of food as a unifying feature of humanity was chosen as a topic to both bring together students of ...
Coxon, Selby, Richardson, Mark, De Bono, Arthur, Allen, Jonathon (R13609)   +3 more
core  

Synthesis and Antiviral Evaluation of New N-acylhydrazones Containing Glycine Residue [PDF]

, 2011
N-acylhydrazones containing glycine residue 3a-j and 8a-h were synthesized as HIV-1 capsid protein assembly inhibitors. The structures of the novel N-acylhydrazone derivatives were characterized using different spectroscopic methods.
He, Meizi, Tang, Shixing, Tian, Baohe, Ming Yang, Shixing Tang, Shuguang Chen, Chen, Shuguang, Zhiwu Tan, Indira Hewlett, Jin, Yinxue, Yinxue Jin, Meizi He, Yang, Ming, Tan, Zhiwu, Hewlett, Indira, Baohe Tian   +15 more
core   +1 more source

Factorial experimental design for optimizing selenium sorption on Cyperus laevigatus biomass and green-synthesized nano-silver

Alexandria Engineering Journal, 2020
This research was undertaken to optimize the Se(IV) adsorption from aqueous solutions by Cyperus laevigatus biomass and green-synthesized nanosilver (AgNPs).
Nadia B.E. Badr, Khairia M. Al-Qahtani, Alaa El Din Mahmoud   +2 more
doaj   +1 more source

Spatiotemporal and quantitative analyses of phosphoinositides – fluorescent probe—and mass spectrometry‐based approaches

FEBS Letters, EarlyView.
Fluorescent probes allow dynamic visualization of phosphoinositides in living cells (left), whereas mass spectrometry provides high‐sensitivity, isomer‐resolved quantitation (right). Their synergistic use captures complementary aspects of lipid signaling. This review illustrates how these approaches reveal the spatiotemporal regulation and quantitative
Hiroaki Kajiho, Shin Morioka, Junko Sasaki, Takehiko Sasaki   +3 more
wiley   +1 more source

Phosphatidylinositol 4‐kinase as a target of pathogens—friend or foe?

FEBS Letters, EarlyView.
This graphical summary illustrates the roles of phosphatidylinositol 4‐kinases (PI4Ks). PI4Ks regulate key cellular processes and can be hijacked by pathogens, such as viruses, bacteria and parasites, to support their intracellular replication. Their dual role as essential host enzymes and pathogen cofactors makes them promising drug targets.
Ana C. Mendes, Guilherme M. Azevedo, Amanda P. Barcellos, Diana Bahia   +3 more
wiley   +1 more source

Protein pyrophosphorylation by inositol pyrophosphates — detection, function, and regulation

FEBS Letters, EarlyView.
Protein pyrophosphorylation is an unusual signaling mechanism that was discovered two decades ago. It can be driven by inositol pyrophosphate messengers and influences various cellular processes. Herein, we summarize the research progress and challenges of this field, covering pathways found to be regulated by this posttranslational modification as ...
Sarah Lampe, Tanmay Kumar Mohanty, Rashna Bhandari, Dorothea Fiedler   +3 more
wiley   +1 more source