Results 271 to 280 of about 4,799,167 (393)

Saccharomyces cerevisiae as a toxicological model to study synthetic cannabinoids and its pyrolysis products

open access: green, 2015
Carla Ferreira   +7 more
openalex   +1 more source

Nuclear pore links Fob1‐dependent rDNA damage relocation to lifespan control

open access: yesFEBS Open Bio, EarlyView.
Damaged rDNA accumulates at a specific perinuclear interface that couples nucleolar escape with nuclear envelope association. Nuclear pores at this site help inhibit Fob1‐induced rDNA instability. This spatial organization of damage handling supports a functional link between nuclear architecture, rDNA stability, and replicative lifespan in yeast.
Yamato Okada   +5 more
wiley   +1 more source

Dihydroorotate dehydrogenase (DHODH) regulates trophoblast syncytialization through organelle stress–induced cellular senescence

open access: yesFEBS Open Bio, EarlyView.
The inhibition of mitochondrial dihydroorotate dehydrogenase (DHODH) impairs syncytialization and induces cellular senescence via mitochondrial and endoplasmic reticulum stress in human trophoblast stem cells, elevating sFlt1/PlGF levels, a hallmark of placental dysfunction in hypertensive disorders of pregnancy.
Kanoko Yoshida   +6 more
wiley   +1 more source

A Combinatorial Approach to Synthetic Data Generation for Machine Learning. [PDF]

open access: yesSN Comput Sci
Khadka K   +4 more
europepmc   +1 more source

Synthetic MultidomainProteins Containing Unstructuredand α‑Helical Linkers Reveal a Differential Impact ofMolecular Crowding on Catalytic Activity and Conformation

open access: green
Asfia Sultana (19170880)   +3 more
openalex   +1 more source

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