Results 81 to 90 of about 239,193 (302)

The planar cell polarity protein Vangl2 interacts with the PDZ‐domains of Scribble but not with a unique PDZ‐like domain in Inturned

FEBS Letters, EarlyView.
Structural and biochemical characterisations show that the planar cell polarity (PCP) protein Inturned harbours a unique PDZ‐like domain that does not bind canonical PDZ‐binding motifs (PBMs) like that of another PCP protein Vangl2. In contrast, the apical‐basal polarity protein Scribble contains four PDZ domains that bind Vangl2, but one PDZ domain ...
Stephan Wilmes, Jan Brysch, Carmen Gelze, Lilli Meier, Daniel Kümmel   +4 more
wiley   +1 more source

Non-canonical soluble amyloid-beta aggregates and plaque buffering: controversies and future directions for target discovery in Alzheimer’s disease

Alzheimer’s Research & Therapy, 2017
The specific amyloid-beta (Aβ) species or other amyloid-precursor protein cleavage products that are most directly related to human neurodegeneration and clinical dementia of the Alzheimer’s type have not yet been directly identified.
David L. Brody, Hao Jiang, Norelle Wildburger, Thomas J. Esparza   +3 more
doaj   +1 more source

Tau acetylation at K331 has limited impact on tau pathology in vivo

FEBS Letters, EarlyView.
We mapped tau post‐translational modifications in humanized MAPT knock‐in mice and in amyloid‐bearing double knock‐in mice. Acetylation within the repeat domain, particularly around K331, showed modest increases under amyloid pathology. To test functional relevance, we generated MAPTK331Q knock‐in mice.
Shoko Hashimoto, Yukio Matsuba, Mika Takahashi, Takaomi C. Saido   +3 more
wiley   +1 more source

Valorization of Spent Coffee Grounds, Biochar and other residues to Produce Lightweight Clay Ceramic Aggregates Suitable for Nursery Grapevine Production

Horticulturae, 2020
The valorization of agro-industrial by-products is one of the key strategies to improve agricultural sustainability. In the present study, spent coffee grounds and biochar were used as pore forming agents in the realization of lightweight clay ceramic ...
Domenico Ronga, Mario Parisi, Luisa Barbieri, Isabella Lancellotti, Fernanda Andreola, Cristina Bignami   +5 more
doaj   +1 more source

Managing the complexities of English Language teaching in engineering [PDF]

, 2015
In this 21st century, engineering employers seek professional engineers who have excellent scientific knowledge and are able to demonstrate good communication and problem solving skills.
Mohamed, Mimi Nahariah Azwani
core   +1 more source

Structural insights into an engineered feruloyl esterase with improved MHET degrading properties

FEBS Letters, EarlyView.
A feruloyl esterase was engineered to mimic key features of MHETase, enhancing the degradation of PET oligomers. Structural and computational analysis reveal how a point mutation stabilizes the active site and reshapes the binding cleft, expading substrate scope.
Panagiota Karampa, Konstantinos Makryniotis, Theofani‐Iosifina Sousani, Evangelos Topakas, Vangelis Daskalakis, Maria Dimarogona   +5 more
wiley   +1 more source

Biotic and abiotic binding and bonding mechanisms in soils with long-term differences in management [PDF]

, 2000
During the last decades Denmark has experienced a growing interest in low-input farming systems like organic farming. These systems rely on a high soil fertility to maintain nutrient availability and plant health.
Debosz, Kasia, Elmholt, Susanne, Munkholm, Lars J., Schjønning, Per   +3 more
core  

A methionine‐lined active site governs carbocation stabilization and product specificity in a bacterial terpene synthase

FEBS Letters, EarlyView.
This study reveals a unique active site enriched in methionine residues and demonstrates that these residues play a critical role by stabilizing carbocation intermediates through novel sulfur–cation interactions. Structure‐guided mutagenesis further revealed variants with significantly altered product profiles, enhancing pseudopterosin formation. These
Marion Ringel, Carl P. O. Helmer, Shani Zev, Ronja Driller, Emily Buhr, Markus Reinbold, Renana Schwartz, Gabriel Foley, Mikael Boden, Daniel Garbe, Gerhard Schenk, Dan Thomas Major, Bernhard Loll, Thomas Brück   +13 more
wiley   +1 more source

Exploring aggregation genes in a P. aeruginosa chronic infection model

Journal of Bacteriology
Bacterial aggregates are observed in both natural and artificial environments. In the context of disease, aggregates have been isolated from chronic and acute infections.
Alexa D. Gannon, Jenet Matlack, Sophie E. Darch   +2 more
doaj   +1 more source

Sustainability of Construction Aggregates in Kuwait

ARCHive-SR, 2019
Kuwait is facing a current construction boom with projects worth of more than USD188bn. The huge infrastructure spending plan of Kuwait is reflected with a growing demand of concrete as concrete is the most commonly used building material in the local ...
Sharifa Al-Fadala
doaj   +1 more source