Results 191 to 200 of about 2,952,613 (401)

Advancing the scale of synthetic biology via cross-species transfer of cellular functions enabled by iModulon engraftment [PDF]

Donghui Choe, Connor A. Olson, Richard Szubin, Hannah Yang, Jaemin Sung, Adam M. Feist, Bernhard Ø. Palsson   +6 more
openalex   +1 more source

Optimization-based Eukaryotic Genetic Circuit Design (EuGeneCiD) and modeling (EuGeneCiM) tools: Computational approach to synthetic biology

, 2021
Wheaton L. Schroeder, Anna S. Baber, Rajib Saha   +2 more
openalex   +1 more source

A Powerful Toolkit for Synthetic Biology: Over 3.8 Billion Years of Evolution [PDF]

The combination of evolutionary with engineering principles will enhance synthetic biology. Conversely, synthetic biology has the potential to enrich evolutionary biology by explaining why some adaptive space is empty, on Earth or elsewhere.
Rothschild, Lynn J.
core   +1 more source

LINC01116, a hypoxia‐lncRNA marker of pathological lymphangiogenesis and poor prognosis in lung adenocarcinoma

Molecular Oncology, EarlyView.
The LINC01116 long noncoding RNA is induced by hypoxia and associated with poor prognosis and high recurrence rates in two cohorts of lung adenocarcinoma patients. Here, we demonstrate that besides its expression in cancer cells, LINC01116 is markedly expressed in lymphatic endothelial cells of the tumor stroma in which it participates in hypoxia ...
Marine Gautier‐Isola, Rafael Lopes Goncalves, Marin Truchi, Caroline Lacoux, Célia Scribe, Hugo Cadis, Laetitia Guardini, Sophie Bekisz, Marius Ilié, Paul Hofman, Georges Vassaux, Bernard Mari, Roger Rezzonico   +12 more
wiley   +1 more source

Large-scale genomic rearrangements boost SCRaMbLE in Saccharomyces cerevisiae

Nature Communications
Synthetic Chromosome Rearrangement and Modification by LoxP-mediated Evolution (SCRaMbLE) is a promising tool to study genomic rearrangements. However, the potential of SCRaMbLE to study genomic rearrangements is currently hindered, because a strain ...
Li Cheng, Shijun Zhao, Tianyi Li, Sha Hou, Zhouqing Luo, Jinsheng Xu, Wenfei Yu, Shuangying Jiang, Marco Monti, Daniel Schindler, Weimin Zhang, Chunhui Hou, Yingxin Ma, Yizhi Cai, Jef D. Boeke, Junbiao Dai   +15 more
doaj   +1 more source

ATF4‐mediated stress response as a therapeutic vulnerability in chordoma

Molecular Oncology, EarlyView.
We screened 5 chordoma cell lines against 100+ inhibitors of epigenetic and metabolic pathways and kinases and identified halofuginone, a tRNA synthetase inhibitor. Mechanistically halofuginone induces an integrated stress response, with eIF2alpha phosphorylation, activation of ATF4 and its target genes CHOP, ASNS, INHBE leading to cell death ...
Lucia Cottone, James Dunford, Eleanor Calcutt, Vicki Gamble, Filiz Senbabaoglu Aksu, Lorena Ligammari, Georgina Wherry, Giorgia Gaeta, John C. Christianson, Adrienne M. Flanagan, Udo Oppermann, Adam P. Cribbs   +11 more
wiley   +1 more source

Fostering Conversation about Synthetic Biology Between Publics and Scientists: A Comparison of Approaches and Outcomes

, 2018
Katie Todd, Gretchen Haupt, Elizabeth Kunz Kollmann, Sarah Pfeifle   +3 more
openalex   +1 more source

Standards for plant synthetic biology: a common syntax for exchange of DNA parts [PDF]

, 2015
Nicola J. Patron, Diego Orzáez, Sylvestre Marillonnet, Heribert Warzecha, Colette Matthewman, Mark Youles, Oleg Raitskin, Aymeric Leveau, Gemma Farré, Christian Rogers, Alison G. Smith, Julian M. Hibberd, Alex Webb, James Locke, Sebastián Schornack, Jim W. Ajioka, David C. Baulcombe, Cyril Zipfel, Sophien Kamoun, Jonathan D. G. Jones, Hannah Kuhn, Silke Robatzek, H. Peter van Esse, Dale Sanders, Giles Oldroyd, Cathie Martin, Robert A. Field, Sarah E. O’Connor, Samantha Fox, Brande B. H. Wulff, J. Benjamin Miller, Andrew Breakspear, Guru Radhakrishnan, Pierre‐Marc Delaux, Dominique Loqué, Antonio Granell, Alain Tissier, Patrick M. Shih, Thomas P. Brutnell, W. Paul Quick, Heiko Rischer, Paul D. Fraser, Asaph Aharoni, Christine A. Raines, Paul F. South, Jean‐Michel Ané, Björn Hamberger, Jane A. Langdale, Jens Stougaard, Harro J. Bouwmeester, Michael K. Udvardi, J. A. H. Murray, Vardis Ntoukakis, Patrick Schäfer, Katherine Denby, Keith J. Edwards, Anne Osbourn, Jim Haseloff   +57 more
openalex   +1 more source

Developing evidence‐based, cost‐effective P4 cancer medicine for driving innovation in prevention, therapeutics, patient care and reducing healthcare inequalities

Molecular Oncology, EarlyView.
The cancer problem is increasing globally with projections up to the year 2050 showing unfavourable outcomes in terms of incidence and cancer‐related deaths. The main challenges are prevention, improved therapeutics resulting in increased cure rates and enhanced health‐related quality of life.
Ulrik Ringborg, Joachim von Braun, Julio Celis, Anton Berns, Michael Baumann, Tit Albreht, Nancy Abou‐Zeid, Vanderlei Bagnato, Christian Brandts, Chien‐Jen Chen, Massimiliano di Pietro, Manjit Dosanjh, Thomas Dubois, Alexander Eggermont, Angelika Eggert, Ingemar Ernberg, Sara Faithfull, Johannes Förner, Stefan Fröhling, Manuel Heitor, Leroy Hood, Wei Jiang, Bengt Jönsson, Ravi Kannan, Maria Leptin, Su Li, Peter Lindgren, Douglas Lowy, Jun Ma, Alex Markham, Péter Nagy, Simon Oberst, M. Iqbal Parker, Danielle Rodin, Kevin Ryan, Joachim Schüz, Richard Sullivan, Josep Tabernero, Peter Turkson, Oliver Várhelyi, Harold Varmus, Chijie Wang, Elisabete Weiderpass, Nils Wilking   +43 more
wiley   +1 more source

Storage‐D: A user‐friendly platform that enables practical and personalized DNA data storage

iMeta
Deoxyribonucleic acid (DNA) has been suggested as a very promising medium for data storage in recent years. Although numerous studies have advocated for DNA data storage, its practical application remains obscure and there is a lack of a user‐oriented ...
Xiaoluo Huang, Junting Cui, Wei Qiang, Jianwen Ye, Yu Wang, Xinying Xie, Yuanzhen Li, Junbiao Dai   +7 more
doaj   +1 more source