Results 191 to 200 of about 916,052 (349)

Characterizing epithelial‐mesenchymal transition‐linked heterogeneity in breast cancer circulating tumor cells at a single‐cell level

Molecular Oncology, EarlyView.
In over 50% of non‐metastatic breast cancer patients, circulating tumor cells (CTCs) along the whole epithelial‐mesenchymal transition spectrum are detected. Total CTC number and individual phenotypes relate to aggressive disease characteristics, including lymph node involvement and higher tumor proliferation. At the single‐cell level, mesenchymal CTCs
Justyna Topa, Julia Richert, Tomasz Stokowy, Alicja Staśczak, Mariusz Szajewski, Maciej Ciesielski, Petra M. Grešner, Bartłomiej Tomasik, Łukasz Arcimowicz, Agnieszka Stankiewicz, Grażyna Suchodolska, Elżbieta Senkus, Wiesław Kruszewski, Anna J. Żaczek, Aleksandra Markiewicz   +14 more
wiley   +1 more source

Identification and application of bioparts for plant synthetic biology. [PDF]

Mol Cells
Koo H, Jung M, Lee S, Go S, Kim YM.
europepmc   +1 more source

Standard virtual biological parts: a repository of modular modeling components for synthetic biology [PDF]

, 2010
Michael T. Cooling, Vincent Rouilly, Göksel Mısırlı, James R. Lawson, Tingting Yu, Jennifer Hallinan, Anil Wipat   +6 more
openalex   +1 more source

Aggressive prostate cancer is associated with pericyte dysfunction

Molecular Oncology, EarlyView.
Tumor‐produced TGF‐β drives pericyte dysfunction in prostate cancer. This dysfunction is characterized by downregulation of some canonical pericyte markers (i.e., DES, CSPG4, and ACTA2) while maintaining the expression of others (i.e., PDGFRB, NOTCH3, and RGS5).
Anabel Martinez‐Romero, Ane Martinez‐Larrinaga, Joaquim Grego‐Bessa, Saioa Garcia‐Longarte, Hielke van Splunder, Ianire Astobiza, Amaia Ercilla, Laura Bozal‐Basterra, Isabel Mendizabal, Pilar Villacampa, Arkaitz Carracedo, Mariona Graupera   +11 more
wiley   +1 more source

Unveiling the Frontiers of Synthetic Biology in Brazil: Pioneering the National Synthetic Biology Network. [PDF]

ACS Omega
Santos LV, Maklouf GR, do Nascimento CZS, Lins MRCR, Rezende JC, Rojas CA, Sampaio Y, El Kadri NK, Kundlatsch GE, Simão RCG, Rech EL, Silva LF, Pedrolli DB.   +12 more
europepmc   +1 more source

Design and characterization of molecular tools for a Synthetic Biology approach towards developing cyanobacterial biotechnology [PDF]

, 2010
Hsin-Ho Huang, Daniel Camsund, Peter Lindblad, Thorsten Heidorn   +3 more
openalex   +1 more source

The neural crest‐associated gene ERRFI1 is involved in melanoma progression and resistance toward targeted therapy

Molecular Oncology, EarlyView.
ERRFI1, a neural crest (NC)‐associated gene, was upregulated in melanoma and negatively correlated with the expression of melanocytic differentiation markers and the susceptibility of melanoma cells toward BRAF inhibitors (BRAFi). Knocking down ERRFI1 significantly increased the sensitivity of melanoma cells to BRAFi.
Nina Wang, Qian Sun, Daniel Novak, Lei Zhu, Juliane Poelchen, Tamara Steinfass, Yiman Wang, Viktor Umansky, Jochen Utikal   +8 more
wiley   +1 more source

Synthetic biology for space exploration. [PDF]

NPJ Microgravity
Onofri S, Moeller R, Billi D, Balsamo M, Becker A, Benvenuto E, Cassaro A, Catanzaro I, Cockell CS, Desiderio A, Ellis T, Gonzáles-Pastor JE, Hahn C, Leys N, Leo P, Maurel MC, Pacelli C, Pavletic B, Ripa C, Rothschild LJ, Surdo L.   +20 more
europepmc   +1 more source

Engineering of a genome-reduced host: practical application of synthetic biology in the overproduction of desired secondary metabolites [PDF]

, 2010
Hong Gao, Ying Zhuo, Elizabeth Jane Ashforth, Lixin Zhang   +3 more
openalex   +1 more source

Survivin and Aurora Kinase A control cell fate decisions during mitosis

Molecular Oncology, EarlyView.
Aurora A interacts with survivin during mitosis and regulates its centromeric role. Loss of Aurora A activity mislocalises survivin, the CPC and BubR1, leading to disruption of the spindle checkpoint and triggering premature mitotic exit, which we refer to as ‘mitotic slippage’.
Hana Abdelkabir, Shalitha Wickrama Arachchige, Sally P. Wheatley   +2 more
wiley   +1 more source