Results 211 to 220 of about 934,952 (299)

Engineered Clostridium butyricum: a promising application of synthetic biology in comprehensive health. [PDF]

Microb Cell Fact
Li K, Kong Y, Chen T.
europepmc   +1 more source

Cutaneous Melanoma Drives Metabolic Changes in the Aged Bone Marrow Immune Microenvironment

Aging and Cancer, EarlyView.
Melanoma, the deadliest form of skin cancer, increasingly affects older adults. Our study reveals that melanoma induces changes in iron and lipid levels in the bone marrow, impacting immune cell populations and increasing susceptibility to ferroptosis.
Alexis E. Carey, Murilo Ramos Rocha, Cheyenne Palm, Vania Wang, Denys Balandin, Ethan Black, Kevin Y. Zhang, Fan Huang, Daniel J. Zabransky, Yash Chhabra, Mareike Peters, Gabriel Ghiaur, Ashani Weeraratna   +12 more
wiley   +1 more source

A synthetic biology toolkit for rationally designing genetic circuits in <i>Acinetobacter baumannii</i>. [PDF]

Front Syst Biol
Letrari S, Faccincani L, Intini S, Ertan I, Varaschin T, Galiazzo F, Costanzo M, D'angelo G, Del Giudice V, Guarnieri L, Martini A, Picchi A, Ravazzolo C, Venturini Degli Esposti N, Zanin C, Trainotti L, De Pittà C, Del Vecchio C, Castagliuolo I, Bellato M.   +19 more
europepmc   +1 more source

Natural Products as Geroprotective Modulators in Diabetic Nephropathy: A Mechanistic Framework Integrating Aging Hallmarks and the AMPK–SIRT1–Nrf2 Axis

Aging and Cancer, EarlyView.
Natural products target the aging kidney in diabetic nephropathy by restoring the AMPK–SIRT1–Nrf2 axis, reducing oxidative stress, inflammation, fibrosis, and cellular senescence while enhancing mitochondrial biogenesis and antioxidant defenses.
Sherif Hamidu, Latif Adams, Eunice Ampem‐Danso, Justice Kumi, Abigail Aning, Fatima Hamidu, Mustapha Abdul Mumin Mohammed, Ayuba Nii Darku Ankrah, Seth Kwabena Amponsah   +8 more
wiley   +1 more source

High-throughput yeast engineering in biofoundries: towards autonomous and scalable synthetic biology. [PDF]

FEMS Yeast Res
Martinez JPO, Speight RE.
europepmc   +1 more source

Mutant NPM1 in Acute Myeloid Leukemia Initiation and Maintenance

Aging and Cancer, EarlyView.
NPM1 mutations drive acute myeloid leukemia by acting as neomorphic transcriptional regulators that cooperate with Menin–MLL and XPO1 to sustain HOX/MEIS1 expression and block differentiation. Targeting these mutant‐specific transcriptional dependencies provides a rational therapeutic strategy for NPM1‐mutated AML.
Yanan Jiang, Zhong Fan, Runmeng Liu, Xiaotian Zhang   +3 more
wiley   +1 more source

Assessing the inhibition efficacy of clinical drugs against the main proteases of SARS‐CoV‐2 variants and other coronaviruses

Quantitative Biology
Wenlong Zhao, Cecylia S. Lupala, Shifeng Hou, Shuxin Yang, Ziqi Yan, Shujie Liao, Xuefei Li, Nan Li   +7 more
doaj   +1 more source

A modular synthetic biology toolkit unlocks metabolic engineering of the industrially relevant alga Nannochloropsis. [PDF]

Adv Biotechnol (Singap)
Guo Y, Li Z, Wang H, Zheng J, Liang Z, Sun H, Zhou W, Liu J.   +7 more
europepmc   +1 more source

Effects of Biological Sex and Age on Cerebrospinal Fluid Markers—A Retrospective Observational Study

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Objective Cerebrospinal fluid (CSF) analysis is a key diagnostic tool for neurological diseases. To date, only a few studies have investigated in larger cohorts the effect of age and biological sex on diagnostic markers extracted from CSF. Methods For this retrospective observational study, 4163 CSF findings (2012–2020) were evaluated.
Isabel‐Sophie Hafer, Simon Faissner, Ralf Gold, Aiden Haghikia   +3 more
wiley   +1 more source

Publisher Correction: Engineering modular and orthogonal genetic logic gates for robust digital-like synthetic biology. [PDF]

Nat Commun
Wang B, Kitney RI, Joly N, Buck M.
europepmc   +1 more source