Results 201 to 210 of about 427,199 (265)

Synthetic biology for space exploration. [PDF]

NPJ Microgravity
Onofri S, Moeller R, Billi D, Balsamo M, Becker A, Benvenuto E, Cassaro A, Catanzaro I, Cockell CS, Desiderio A, Ellis T, Gonzáles-Pastor JE, Hahn C, Leys N, Leo P, Maurel MC, Pacelli C, Pavletic B, Ripa C, Rothschild LJ, Surdo L.   +20 more
europepmc   +1 more source

CAR T‐Cell Therapy in Neurology: A Scoping Review of Neuro‐Oncology, Autoimmune Diseases & Neurotoxicity

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Chimeric antigen receptor (CAR) T‐cell therapy has been investigated in neurological diseases, encompassing both central nervous system malignancies and autoimmune disorders, thereby extending its application beyond hematological cancers.
Omar Alqaisi, Mohammed Dibas, Patricia Tai, Ala Dibas, Osama Souied, Suhair Al‐Ghabeesh   +5 more
wiley   +1 more source

Editorial: Synthetic biology approaches for biocatalytic production of value-added chemicals. [PDF]

Front Bioeng Biotechnol
Peng H, Patel SKS, Lee JK.
europepmc   +1 more source

Unraveling 4‐Phenylbutyrate's Therapeutic Role in SLC6A1 Disorders: Pharmacochaperoning Over HDAC Inhibition

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Objective Variants in SLC6A1, encoding the GABA transporter 1 (GAT‐1), cause epilepsy, autism spectrum disorder, and developmental delay via loss of GABA uptake, impaired trafficking, and ER retention. We previously found that 4‐Phenylbutyrate (PBA), an FDA‐approved drug, restores GABA uptake and reduces seizures in SLC6A1‐related disorders ...
Melissa B. DeLeeuw, Karishma Randhave, Ekta Anand, Ziang (Debbie) Song, Wangzhen Shen, Jing‐Qiong Kang   +5 more
wiley   +1 more source

Rhodo-Box: A Synthetic Biology Toolbox to Facilitate Metabolic Engineering of <i>Rhodobacter sphaeroides</i>. [PDF]

ACS Synth Biol
Kostanjšek M, Raynal A, Dimopoulos G, Behrendt G, Martins Dos Santos VAP, Beekwilder J, Batianis C, Weusthuis RA, Asin-Garcia E, Bisschops MMM.   +9 more
europepmc   +1 more source

Neurochemical Endpoints to Inform Early‐Stage Trials of Spinocerebellar Ataxia 2 and 3 in a Multisite Setting

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Objective Neurochemical levels measured by brain MR spectroscopy (MRS) have been proposed as endpoints for clinical trials in early‐stage spinocerebellar ataxia (SCA) trials. We tested their trial‐readiness by quantifying neurochemicals in three affected brain regions in early‐stage cohorts of SCA2 and SCA3, examining their reproducibility in ...
James M. Joers, Yaqiao Wei, Dinesh K. Deelchand, Adam Berrington, Young Woo Park, Guita Banan, Michal Povazan, Jens T. Rosenberg, André J. W. van der Kouwe, Tetsuo Ashizawa, Khalaf O. Bushara, Chiadi U. Onyike, Sub H. Subramony, Jeremy D. Schmahmann, Brian J. Soher, Peter B. Barker, Thomas H. Mareci, Eva‐Maria Ratai, Lynn E. Eberly, Gülin Öz   +19 more
wiley   +1 more source

Recent technology advancements in large‐scale DNA assembly

Quantitative Biology
Jielin Li, Li Cheng, Yingxin Ma, Yizhi Cai, Junbiao Dai   +4 more
doaj   +1 more source

Engineering the holobiont: Synthetic biology strategies for reversing bioenergetic collapse in radiation enteritis. [PDF]

AIMS Microbiol
Li Y, Liang J, Yin H, Liu T.
europepmc   +1 more source

Sex Differences in Medication Discontinuation in Axial Spondyloarthritis

Arthritis Care &Research, EarlyView.
Objective We examined sex differences in medication discontinuation among patients with axial spondyloarthritis (axSpA) initiating tumor necrosis factor inhibitors (TNFi), interleukin‐17 inhibitors (IL‐17i), or JAK inhibitors (JAKi). Methods Using data from the Rheumatology Informatics System for Effectiveness (RISE) Registry (2003–2025), we assessed ...
Rachael Stovall, Cinthia Blat, Eric Roberts, Jean W. Liew, Katherine Wysham, Namrata Singh, Janna Friedly, Lianne S. Gensler, Gabriela Schmajuk, Jinoos Yazdany   +9 more
wiley   +1 more source

Governing Synthetic Biology: A Co-Evolutionary Framework for Sustainable Innovation. [PDF]

J Microbiol Biotechnol
Kim H, Lee J, Cho Y, Kim H, Kim HY, Sung BH.   +5 more
europepmc   +1 more source