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2023
Over the last four billion years, unicellular and multicellular living systems have evolved to be highly adaptable in a variety of environments found on our blue planet. The success of cellular life not only lies in the versatility of the molecular building blocks (e.g., amino acids, nucleotides, lipids, and other small molecules) of which it is ...
Llopis-Lorente, Antoni +4 more
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Over the last four billion years, unicellular and multicellular living systems have evolved to be highly adaptable in a variety of environments found on our blue planet. The success of cellular life not only lies in the versatility of the molecular building blocks (e.g., amino acids, nucleotides, lipids, and other small molecules) of which it is ...
Llopis-Lorente, Antoni +4 more
openaire +3 more sources
Toward synthetic life: Biomimetic synthetic cell communication
Current Opinion in Chemical Biology, 2021Engineering synthetic minimal cells provide a controllable chassis for studying the biochemical principles of natural life, increasing our understanding of complex biological processes. Recently, synthetic cell engineering has enabled communication between both natural live cells and other synthetic cells.
Abbey O. Robinson +2 more
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Science, 2019
Frog egg cytoplasm self-organizes into cell-like units by microtubule aster assembly and ...
Timothy J, Mitchison, Christine M, Field
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Frog egg cytoplasm self-organizes into cell-like units by microtubule aster assembly and ...
Timothy J, Mitchison, Christine M, Field
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Dynamic Control of Functional Coacervates in Synthetic Cells.
ACS Synthetic Biology, 2023Membrane-less compartments formed via liquid-liquid phase separation (LLPS) are regulated dynamically via enzyme reactions in cells. Giant unilamellar vesicles (GUVs) provide a promising chassis to control, mimic, and understand the LLPS process; however,
Karthika S Nair +2 more
semanticscholar +1 more source
Biomacromolecules, 2023
Synthetic cells are artificial constructs that mimic the structures and functions of living cells. They are attractive for studying diverse biochemical processes and elucidating the origins of life.
Jackson Powers, Yeon-Do Jang
semanticscholar +1 more source
Synthetic cells are artificial constructs that mimic the structures and functions of living cells. They are attractive for studying diverse biochemical processes and elucidating the origins of life.
Jackson Powers, Yeon-Do Jang
semanticscholar +1 more source
Physical Biology, 2018
How do the cells in our body reconfigure their shape to achieve complex tasks like migration and mitosis, yet maintain their shape in response to forces exerted by, for instance, blood flow and muscle action? Cell shape control is defined by a delicate mechanical balance between active force generation and passive material properties of the plasma ...
Yuval Mulla +2 more
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How do the cells in our body reconfigure their shape to achieve complex tasks like migration and mitosis, yet maintain their shape in response to forces exerted by, for instance, blood flow and muscle action? Cell shape control is defined by a delicate mechanical balance between active force generation and passive material properties of the plasma ...
Yuval Mulla +2 more
openaire +2 more sources
Engineering Tissue-Scale Properties with Synthetic Cells: Forging One from Many.
ACS Synthetic Biology, 2023In metazoans, living cells achieve capabilities beyond individual cell functionality by assembling into multicellular tissue structures. These higher-order structures represent dynamic, heterogeneous, and responsive systems that have evolved to ...
Alexander J. Lin +2 more
semanticscholar +1 more source
Progress Toward Synthetic Cells
Annual Review of Biochemistry, 2014The complexity of even the simplest known life forms makes efforts to synthesize living cells from inanimate components seem like a daunting task. However, recent progress toward the creation of synthetic cells, ranging from simple protocells to artificial cells approaching the complexity of bacteria, suggests that the synthesis of life is now a ...
J Craig, Blain, Jack W, Szostak
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Chemical Zymogens and Transmembrane Activation of Transcription in Synthetic Cells
Advances in Materials, 2023In this work, synthetic cells equipped with an artificial signaling pathway that connects an extracellular trigger event to the activation of intracellular transcription are engineered.
D. Andersen +8 more
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Cell‐Responsive Synthetic Hydrogels
Advanced Materials, 2003Synthetic biomaterial matrices have been formed in the presence of cells by a Michael‐type addition reaction between a difunctional protease substrate peptide, a monofunctional cell adhesion peptide, and a tetrafunctional poly(ethylene glycol). These materials locally degrade in response to cell‐surface proteases, allowing cells to create paths for 3D ...
Lutolf, Matthias P. +4 more
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