Results 51 to 60 of about 1,906,510 (288)

Soft motions encoded by the fold and mediated by conserved hinge sites drive V‐ATPase allosteric machinery and autoinhibition

FEBS Letters, EarlyView.
Vacuolar H+‐ATPase (V‐ATPase) is a multisubunit rotary proton pump that acidifies intracellular compartments. Using elastic network models, we identified conserved hinge residues that govern its large‐scale functional motions. We show that intrinsically encoded ‘soft modes’ drive critical functional transitions, including rotary catalysis and ...
Diksha Parwana, Xiaowei Bogetti, Stuti Sharma, Ivet Bahar   +3 more
wiley   +1 more source

Spatial resolution enhancement using deep learning improves chest disease diagnosis based on thick slice CT

npj Digital Medicine
CT is crucial for diagnosing chest diseases, with image quality affected by spatial resolution. Thick-slice CT remains prevalent in practice due to cost considerations, yet its coarse spatial resolution may hinder accurate diagnoses.
Pengxin Yu, Haoyue Zhang, Dawei Wang, Rongguo Zhang, Mei Deng, Haoyu Yang, Lijun Wu, Xiaoxu Liu, Andrea S. Oh, Fereidoun G. Abtin, Ashley E. Prosper, Kathleen Ruchalski, Nana Wang, Huairong Zhang, Ye Li, Xinna Lv, Min Liu, Shaohong Zhao, Dasheng Li, John M. Hoffman, Denise R. Aberle, Chaoyang Liang, Shouliang Qi, Corey Arnold   +23 more
doaj   +1 more source

Improvement of Quantification of Myocardial Synthetic ECV with Second-Generation Deep Learning Reconstruction

Journal of Cardiovascular Development and Disease
Background: The utility of synthetic ECV, which does not require hematocrit values, has been reported; however, high-quality CT images are essential for accurate quantification.
Tsubasa Morioka, Shingo Kato, Ayano Onoma, Toshiharu Izumi, Tomokazu Sakano, Eiji Ishikawa, Shungo Sawamura, Naofumi Yasuda, Hiroaki Nagase, Daisuke Utsunomiya   +9 more
doaj   +1 more source

Inhibition of cyclin‐dependent kinases 12/13 using CT7439 as a treatment for colorectal cancer with CDK12 upregulation

Molecular Oncology, EarlyView.
The proposed mechanism of action for the CDK12/13 inhibitor and cyclin K degrader, CT7439. CDK12/13 inhibition interrupts transcription elongation, leading to increased DNA damage that results in cell death. This agent is a potentially novel treatment option for patients with colorectal cancer. Created in BioRender. Cyclin‐dependent kinase (CDK) 12 and
Wylie K. Watlington, Divya L. Dayanidhi, Mohammad Zokaasadi, John B. Mantyh, Pelumi D. Olawuni, Gabrielle Rupprecht, Jeremy M. Force, Shannon McCall, Ashwani K. Bahl, David S. Hsu, Jason A. Somarelli   +10 more
wiley   +1 more source

Radiation-free diagnosis of lumbar spondylolysis: case series evaluating MRI-based synthetic CT efficacy

The Egyptian Journal of Radiology and Nuclear Medicine
Background Computed tomography (CT) is favored for diagnosing lumbar spondylolysis owing to its high resolution, rapid scanning, and cost-effectiveness.
Gan Cao, Jichao Zhu, Anyu Yin, Shanghuang Xie, Xiaolin Yang, Helin Liu, Feiyuan Zhang, Ling Luo, Zhaotong Li, Jun Xia   +9 more
doaj   +1 more source

Circulating microRNA signatures of cachexia and cancer in Canis familiaris as a comparative oncology model for human disease

Molecular Oncology, EarlyView.
Circulating microRNAs as biomarkers of cachexia and sex‐specific cancer in senior dogs. In 25 client‐owned dogs, four circulating miRNAs (miR‐15a, miR‐15b, miR‐16, miR‐140) were downregulated in cachexia, with miR‐16 the strongest individual biomarker (AUC = 0.899).
Soon‐Seok Park, Kyongman An, Gyeonghwa Kim, Soo‐Nyun Choi, Hong‐Ki Lee, Keun Hur, Kyu‐Shik Jeong   +6 more
wiley   +1 more source

Lumbar Spine Computed Tomography to Magnetic Resonance Imaging Synthesis Using Generative Adversarial Network: Visual Turing Test

Diagnostics, 2022
(1) Introduction: Computed tomography (CT) and magnetic resonance imaging (MRI) play an important role in the diagnosis and evaluation of spinal diseases, especially degenerative spinal diseases.
Ki-Taek Hong, Yongwon Cho, Chang Ho Kang, Kyung-Sik Ahn, Heegon Lee, Joohui Kim, Suk Joo Hong, Baek Hyun Kim, Euddeum Shim   +8 more
doaj   +1 more source

A role for eIF5A in translational control of stress‐inducible proteins in multiple myeloma cell lines

Molecular Oncology, EarlyView.
Loss of eIF5A rewires thapsigargin‐mediated endoplasmic reticulum stress responses in multiple myeloma cells by selective translation of mRNA transcripts, consequently dampening thapsigargin‐induced unfolded protein response (UPR) activation and shifting the balance from induction of apoptosis toward cell survival and proliferation.
Demi Both, Ingrid A. M. Derks, Raphaël Vanleyssem, Marine Leclercq, Najla El Hachem, Pierre Close, Eric Eldering, Marco Vincent Haselager   +7 more
wiley   +1 more source

Clinical feasibility of deep learning-based synthetic CT images from T2-weighted MR images for cervical cancer patients compared to MRCAT

Scientific Reports
This work aims to investigate the clinical feasibility of deep learning-based synthetic CT images for cervix cancer, comparing them to MR for calculating attenuation (MRCAT).
Hojin Kim, Sang Kyun Yoo, Jin Sung Kim, Yong Tae Kim, Jai Wo Lee, Changhwan Kim, Chae-Seon Hong, Ho Lee, Min Cheol Han, Dong Wook Kim, Se Young Kim, Tae Min Kim, Woo Hyoung Kim, Jayoung Kong, Yong Bae Kim   +14 more
doaj   +1 more source

Cone-Beam CT to Synthetic CT Translation Using Conditional 3D Latent Diffusion-Based Model

IEEE Access
Accurate cone-beam CT (CBCT)-to-synthetic CT (sCT) translation is essential for image-guided adaptive radiotherapy (IGART), where Hounsfield unit (HU) fidelity and structural accuracy directly affect dose calculation.
Mohammed Al-Shalabi, Mohammed A. Mahdi, Reda Elbarougy, Ehab Tawfeek Alnfrawy, Muhammad Usman Hadi, Rao Faizan Ali   +5 more
doaj   +1 more source