Results 61 to 70 of about 1,906,510 (288)

Synthetic PET From CT Improves Diagnosis and Prognosis for Lung Cancer: Proof of Concept [PDF]

[18F]Fluorodeoxyglucose positron emission tomography (FDG-PET) and computed tomography (CT) are indispensable components in modern medicine. Although PET can provide additional diagnostic value, it is costly and not universally accessible, particularly ...
Siewerdsen, Jeffrey H, Godoy, Myrna C B, Sujit, Sheeba J, Chen, Pingjun, Sepesi, Boris, Hazle, John D, Toumazis, Iakovos, Hong, Lingzhi, Antonoff, Mara B, Wu, Jia, Wistuba, Ignacio, Cascone, Tina, Qayati, Mohamed, Chung, Caroline, Karpinets, Tatiana V, Jaffray, David, Salehjahromi, Morteza, Vokes, Natalie I, Gladish, Gregory, Bandyopadhyay, Rukhmini, Zhang, Jianhua, Lu, Yang, Saad, Maliazurina B, Sheshadri, Ajay, Ostrin, Edwin J, Cheng, Chao, Lin, Julie, Vaporciyan, Ara A, Lee, J Jack, Wu, Carol C, Zhang, Jianjun, Behrens, Carmen, Heymach, John V, Aminu, Muhammad, Huang, Peng, Gibbons, Don L, Chang, Joe Y   +36 more
core   +1 more source

Regulation of the lncRNA NEAT1 by p53‐ΔNp63 crosstalk modulates the DNA damage response and therapeutic efficacy in HNSCC

Molecular Oncology, EarlyView.
In head and neck squamous cell carcinoma (HNSCC) p53 and p63 exert opposite roles on the transcription regulation of the lncRNA NEAT1. Under basal conditions, p53 levels are low and p63 represses NEAT1 expression. Upon genotoxic stress, p53 is rapidly induced, displacing p63 from the NEAT1 promoter leading to NEAT1 transcriptional activation and ...
Sara De Domenico, Veronica La Banca, Silvia D'Amico, Stefano Scalera, Sara Nicolai, Angelo Peschiaroli   +5 more
wiley   +1 more source

Evaluation of magnetic resonance imaging and deep learning-based synthetic computed tomography for calcified intradural tumors – importance of domain-specific training and validation of synthetic imaging methods for clinical application

Acta Neurochirurgica
Purpose For intradural spinal tumors, information on the degree of calcification is helpful to plan the surgery. Novel deep-learning algorithms allow to generate synthetic computed tomography (CT) images from magnetic resonance imaging (MRI).
Gregor Fischer, Felix C. Stengel, Lorenzo Bertulli, Linda Bättig, Victor E. Staartjes, Tobias Dietrich, Olaf Chan-Hi Kim, Martin N. Stienen   +7 more
doaj   +1 more source

Synthetic computed tomography techniques for adaptive proton therapy in head and neck cancers

Physics and Imaging in Radiation Oncology
Head and neck (HN) radiotherapy often requires corrective interventions. This study evaluated three methods for synthetic computed tomography (CT) generation for adaptive HN planning using cone-beam CT (CBCT) images.
Suryakant Kaushik, Nadine Vatterodt, Jakob Ödén, Albin Fredriksson, Stine S. Korreman, Iuliana Toma-Dasu   +5 more
doaj   +1 more source

Bone regeneration in critical size calvarial defects using synthetic hydroxyapatite and mineralized bovine tendon base materials: a micro-computed tomography analysis

Acta Scientiarum: Technology, 2023
This investigation used materials based on synthetic hydroxyapatite and mineralized bovine tendon as a framework for bone regeneration and evaluated the osteoconductivity of these materials in the calvaria of Wistar rats in comparison to Bio-Oss ...
Maurí­cio Bordini do Amaral, Rommel Bezerra Viana, Katúcia Bezerra Viana, Cristina Aparecida Diagone, Aline Bassi Denis, Ana Maria de Guzzi Plepis   +5 more
doaj   +1 more source

SPHINX31 acts as a SRPK1 inhibitor targeting the ATR/DNA‐PKcs/CHK1 replicative checkpoint to inhibit cell growth in non‐small cell lung cancer

Molecular Oncology, EarlyView.
The kinase SRPK1 directly interacts with the protein TOPBP1 and regulates the pre‐mRNA splicing of WIZ thereby contributing to the activation of the ATR/CHK1 replicative checkpoint in response to replicative stress. This allows cancer cells' genomic stability and survival.
Amani Shreim, Aurelie Genoux, Nadiia Zubchuk, Haoyang Zheng, Perla Salameh, Theo Ziegelmeyer, Fabien Dalonneau, Margot Rouchette, Christiane Oddou, Simona Miron, Helene Polveche, Adiilah Mamode Cassim, Carmen Garrido, Eleni Nikolakaki, Didier Auboeuf, Tao Jia, Sophie Zinn‐Justin, Beatrice Eymin   +17 more
wiley   +1 more source

Reprogramming tumor cells with LCOR mRNA nanotherapy to enhance immunotherapy

Molecular Oncology, EarlyView.
LCOR (Ligand‐dependent corepressor) mRNA encapsulated in polymeric nanoparticles restores LCOR activity in tumor cells, constraining aggressive tumor cell states and increasing tumor immunogenicity. This reprogramming makes tumor cells more vulnerable to T‐cell attack and enhances their response to immune‐checkpoint immunotherapy.
Gabriel Serra‐Mir, Elena Haro‐Martínez, Sandra Blasco‐Benito, Chiara Cannatà, José Ángel Palomeque, Anna López‐Plana, Maria Sanz‐Flores, Marc Sabartés, Cristina Fornaguera, Toni Celià‐Terrassa   +9 more
wiley   +1 more source

USP7 inhibits FOXO1 activity in chronic lymphocytic leukaemia cells enhancing cell survival

Molecular Oncology, EarlyView.
CLL cells rely on BCR‐mediated signalling for survival and proliferation in part through suppression of FOXO1. FOXO1 activity is regulated by a plethora of post‐translational modifications including phosphorylation and ubiquitination. We demonstrated that dual inhibition of BCR signalling and the deubiquitinase USP7 activates FOXO1, modulating its ...
Hassan N.B. Almuhanna, Jodie Hay, Michael W. Moles, Lucy Clarke, Jennifer Cassels, Alison Sefcick, Alison M. McCaig, Heather G. Jørgensen, Alison M. Michie   +8 more
wiley   +1 more source

A Hybrid X-Ray Computed Tomography System for Education and Synthetic Data Generation for AI Model Training

e-Journal of Nondestructive Testing
We present a hybrid X-ray Computed Tomography (CT) system designed for both education and AI data generation. It upgrades a legacy X-Ray system with digital detectors, precise mechanics, and modern controls.
Martin Simon, Robin Tenscher-Philipp, Tim Schanz   +2 more
doaj   +1 more source

Synthetic CT generation for MRI-guided adaptive radiotherapy in prostate cancer

Frontiers in Oncology, 2022
Current MRI-guided adaptive radiotherapy (MRgART) workflows require fraction-specific electron and/or mass density maps, which are created by deformable image registration (DIR) between the simulation CT images and daily MR images.
Shu-Hui Hsu, Zhaohui Han, Jonathan E. Leeman, Yue-Houng Hu, Raymond H. Mak, Atchar Sudhyadhom   +5 more
doaj   +1 more source