Results 81 to 90 of about 1,906,510 (288)

BCG vaccination potentiates oxidative phosphorylation in neonatal myeloid‐derived suppressor cells

FEBS Open Bio, EarlyView.
BCG vaccination enhances oxidative phosphorylation in neonatal MDSCs, impairing their immunosuppressive function. It upregulates electron transport chain genes and mitochondrial activity, increasing ATP and oxygen consumption. Pharmacological OXPHOS inhibition partially restores suppressive capacity, confirming causality.
Yingying Chen, Hui Li
wiley   +1 more source

Synthesizing lumbar computed tomography myelography from plain computed tomography images using a cycle-consistent generative adversarial network

North American Spine Society Journal
: Background: Magnetic resonance imaging (MRI) is the gold standard for diagnosing lumbar canal stenosis (LCS), but it may be contraindicated in patients with implants or claustrophobia.
Ryo Itoga, MD, Terufumi Kokabu, MD, PhD, Koji Kato, PhD, Yoshinori Hyugaji, Jun Wakasa, MD, Yasushi Yanagibashi, MD, Takahiko Hyakumachi, MD, Yoshihiro Hojo, MD, PhD, Ken Nagahama, MD, PhD, Masahiro Kanayama, MD, PhD, Ryo Fujita, MD, PhD, Tomohiro Shimizu, MD, PhD, Tsutomu Endo, MD, PhD, Takashi Ohnishi, MD, PhD, Daisuke Ukeba, MD, PhD, Hideki Sudo, MD, PhD, Katsuhisa Yamada, MD, PhD, Norimasa Iwasaki, MD, PhD   +17 more
doaj   +1 more source

Synthetic CT Generation from MR Images : A U-Net Deep Learning Approach [PDF]

openComputed Tomography (CT) and Magnetic Resonance Imaging (MRI) work hand in hand in radiation therapy planning—CT delivers essential attenuation data for accurate dose calculations, while MRI excels at capturing detailed soft tissue contrasts ...
JAFARPOUR, FARSHAD
core  

Dactolisib outperforms Rapamycin in potentiating apoptosis induced by XPO1, Bcl‐2 and Mcl‐1 blockade in preclinical glioblastoma models

FEBS Open Bio, EarlyView.
The PAM pathway and its impact on cellular metabolism. Color‐coded key symbols represent Rapamycin (R, orange, targeting mTOR) and Dactolisib (D, green, targeting PI3K/mTOR), indicating their sites of action. Created with BioRenders.com. Glioblastoma resists therapy through interconnected survival programs.
Kai Zhao, Leonie Meyer, Madita Braun, Katharina Otte, Celine Bitter, Maite Pawlik, Hartmann Raifer, Frederik Helmprobst, Axel Pagenstecher, Hans Urban, Michael C. Burger, Michael W. Ronellenfitsch, Joachim P. Steinbach, Jarmila Jedelská, Shamim Bagheri, Behrooz H. Yousefi, Pietro Di Fazio, Markus Luster, Andreas H. Mahnken, Andreas Neubauer, Andreas Burchert, Christopher Nimsky, Jörg W. Bartsch, Tillmann Rusch   +23 more
wiley   +1 more source

Toward Closing the Loop in Image-to-Image Conversion in Radiotherapy: A Quality Control Tool to Predict Synthetic Computed Tomography Hounsfield Unit Accuracy

Journal of Imaging
In recent years, synthetic Computed Tomography (CT) images generated from Magnetic Resonance (MR) or Cone Beam Computed Tomography (CBCT) acquisitions have been shown to be comparable to real CT images in terms of dose computation for radiotherapy ...
Paolo Zaffino, Ciro Benito Raggio, Adrian Thummerer, Gabriel Guterres Marmitt, Johannes Albertus Langendijk, Anna Procopio, Carlo Cosentino, Joao Seco, Antje Christin Knopf, Stefan Both, Maria Francesca Spadea   +10 more
doaj   +1 more source

Common incidental findings on sacroiliac joint MRI : added value of MRI-based synthetic CT

, 2023
Purpose: To determine the prevalence of incidental findings on sacroiliac joint MRI and to determine the added value of MRI-based synthetic CT in the detection and evaluation of these incidental findings.Method: In this retrospective study 210 patients ...
Morbée, Lieve, Jans, Lennart, Vereecke, Elke, Chen, Min, Laloo, Frederiek, Herregods, Nele   +5 more
core   +1 more source

Cerebrospinal Fluid Over Plasma Links Analytes to Cognitive Decline in Older Adults at Risk for Alzheimer's Disease

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Objective To identify inflammatory analytes in cerebrospinal fluid (CSF) and plasma associated with cognitive decline in cognitively normal (CN) older adults at risk for Alzheimer's disease (AD). Methods In a longitudinal study of 118 CN older adults (65–80 years, 54% APOE ε4, 26% preclinical AD), 1331 CSF and 1501 plasma analytes were ...
Jagan A. Pillai, Audrey Zhu, Chunxuan Ma, Ming Wang, Yifan Yang, Lynn M. Bekris, Maria Khrestian, Frank P. DiFilippo, Mikhail Nasrallah, Aaron Burberry, James B. Leverenz, Yuan Hou, Feixiong Cheng, Stephen M. Rao   +13 more
wiley   +1 more source

Generating High-Resolution Synthetic CT from Lung MRI with Ultrashort Echo Times: Initial Evaluation in Cystic Fibrosis

, 2023
International audienceBackground: Lung MRI with ultrashort echo times (UTE-MRI) enables high-resolution and radiation-free morphological imaging, however, its imaging quality is still lower than CT.
Julien Raoult, Ilyes Benlala, Julie Macey, Gilbert Ferretti, Baptiste Morel, Liberge, Renan, Benlala, Ilyes, Arthur Longuefosse, Berger, Patrick, Hutt, Antoine, Bui, Stéphanie, Baudouin Denis de Senneville, Benkert, Thomas, Dournes, Gaël, Thomas Benkert, Jean-Yves Gaubert, Gaubert, Jean-Yves, Gaël Dournes, Raoult, Julien, Ferretti, Gilbert, Macey, Julie, Stéphanie Bui, Longuefosse, Arthur, François Laurent, Patrick Berger, Antoine Hutt, Laurent, François, Baldacci, Fabien, Renan Liberge, Morel, Baptiste, Denis de Senneville, Baudouin, Fabien Baldacci   +31 more
core   +1 more source

Artificial Intelligence in Systemic Sclerosis: Clinical Applications, Challenges, and Future Directions

Arthritis Care &Research, EarlyView.
Systemic sclerosis (SSc) is a rare autoimmune disease defined by immune dysregulation, vasculopathy, and progressive fibrosis of the skin and internal organs. Despite advances in care, major complications such as interstitial lung disease (ILD) and myocardial involvement remain the leading causes of morbidity and mortality.
Cristiana Sieiro Santos, José Miguel Sequí‐Sabater, Diego Benavent   +2 more
wiley   +1 more source

Clinical Characteristics and Concordance of Anti‐MDA5 Antibodies: A Multicenter Australian Study

Arthritis Care &Research, EarlyView.
Objective In Australia, anti‐MDA5 antibodies are exclusively tested by a line immunoblot assay (LIA). The clinical concordance of an LIA‐positive anti‐MDA5 result is unclear. We aimed to describe the clinical features and determine the clinical concordance of patients with anti‐MDA5 antibodies. Methods Electronic records of a multisite cohort (patients
Syed B. Ali, Thomas Khoo, Keeran Shivakumar, Adam Caroll, Lauren Hender, Dimitra Beroukas, Kim Griggs, Celina Jin, Theo De Malmanche, Jessica Day, Gabor Major, Vidya Limaye   +11 more
wiley   +1 more source